Developing a sense of touch

Jenkins, Blair A.; Lumpkin, Ellen A.

doi:10.1242/dev.120402

Cited by 79Tactile and Sensory InteractionsNeurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal Signaling

Developing a sense of touch

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Jenkins, Blair A., Lumpkin, Ellen A.·2017·Development

DOI 10.1242/dev.120402PMC PMC5719243

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Abstract

The sensation of touch is mediated by mechanosensory neurons that are embedded in skin and relay signals from the periphery to the central nervous system. During embryogenesis, axons elongate from these neurons to make contact with the developing skin. Concurrently, the epithelium of skin transforms from a homogeneous tissue into a heterogeneous organ that is made up of distinct layers and microdomains. Throughout this process, each neuronal terminal must form connections with an appropriate skin region to serve its function. This Review presents current knowledge of the development of the sensory microdomains in mammalian skin and the mechanosensory neurons that innervate them.

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Skin organoids form nascent mechanosensitive touch complexes.
“Our data suggest that skin organoids form nascent mechanosensitive touch complexes33,34.”
From Hair-bearing human skin generated entirely from pluripotent stem cells (2020) · cites this paper as [33]

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Chang, H., & Nathans, J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301430110 · Cited by 34 · see citing works
Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance
Hua, Z. L., Chang, H., Wang, Y., Smallwood, P. M., & Nathans, J. (2014) · Development · doi:10.1242/dev.110189 · Cited by 30 · see citing works
NT3 expressed in skin causes enhancement of SA1 sensory neurons that leads to postnatal enhancement of Merkel cells
Krimm, R. F., Davis, B. M., Woodbury, C. J., & Albers, K. M. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20041 · Cited by 30 · see citing works
Neurotrophin‐3 signaling in mammalian Merkel cell development
Szeder, V., Grim, M., Kučera, J., et al. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10403 · Cited by 29 · see citing works
Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes
Reed-Geaghan, E. G., Wright, M. C., See, L., Adelman, P. C., Lee, K. H., Koerber, H. R., & Maricich, S. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3781-15.2016 · Cited by 29 · see citing works
Excitatory glutamate is essential for development and maintenance of the piloneural mechanoreceptor
Woo, S., Baba, Y., Franco, A. M., Lumpkin, E. A., & Owens, D. M. (2012) · Development · doi:10.1242/dev.070847 · Cited by 29 · see citing works
Self-citation
Myelinated afferent nerve fibers from the skin of the rabbit ear
Brown, A. G., Iggo, A., & Miller, S. (1967) · Experimental Neurology · doi:10.1016/0014-4886(67)90053-2 · Cited by 26 · see citing works
Ruffini endings are absent from the periodontal ligament of trkB knockout mice
Matsuo, S., Ichikawa, H., Silos‐Santiago, I., et al. (2002) · Somatosensory & Motor Research · doi:10.1080/0899022021000009134 · Cited by 26 · see citing works
Dual Innervation of Neonatal Merkel Cells in Mouse Touch Domes
Niu, J., Vysochan, A., & Luo, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092027 · Cited by 24 · see citing works
Postnatal reduction of BDNF regulates the developmental remodeling of taste bud innervation
Huang, T., Ma, L., & Krimm, R. F. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.07.006 · Cited by 22 · see citing works
Netrin-1 signaling for sensory axons
Masuda, T., Yaginuma, H., Sakuma, C., et al. (2009) · Cell Adhesion & Migration · doi:10.4161/cam.3.2.7837 · Cited by 21 · see citing works
Multiple innervation of rat pacinian corpuscles regenerated after neonatal axotomy
Zelena´, J. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90234-7 · Cited by 21 · see citing works
Apoptosis of Merkel cells in neurotrophin-3 null mice
Halata, Z., Kučera, J., Kučera, T., et al. (2005) · Anatomy and Embryology · doi:10.1007/s00429-005-0455-0 · Cited by 17 · see citing works

Flagged first, then by citations

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Research works printed but not linked: 1

Ruffini, 1894, Sur un nouvel organe nerveux terminal et sur la présence des corpuscules Golgi-Mazzoni dans le conjonctif sous-cutané de la pulpe des doigts de l'homme, Arch. Ital. Biol., 21, 249

Sorted by citations

Hair-bearing human skin generated entirely from pluripotent stem cells
Lee, J., Rabbani, C. C., Gao, H., Steinhart, M. R., Woodruff, B. M., Pflum, Z. E., Kim, A., Heller, S., Liu, Y., Shipchandler, T. Z., et al. (2020) · Nature · doi:10.1038/s41586-020-2352-3 · Cited by 487 · see citing works
“Our data suggest that skin organoids form nascent mechanosensitive touch complexes 33,34 .”
Tissue Stem Cells: Architects of Their Niches
Fuchs, E., & Blau, H. M. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.09.011 · Cited by 332 · see citing works
“Additional components of the EpdSC niche are thermal, pain, and touch sensing neurons (Jenkins and Lumpkin, 2017; Neubarth et al., 2020; Paricio-Montesinos et al., 2020; Sharif et al., 2020; Zimmerman et al., 2019; Zylka et al., 2005) and resident immune cells (Jameson et al.”
Background
Cephalopod-Inspired Chromotropic Ionic Skin with Rapid Visual Sensing Capabilities to Multiple Stimuli
Wang, Y., Cao, X., Cheng, J., Yao, B., Zhao, Y., Wu, S., Ju, B., Zhang, S., He, X., & Niu, W. (2021) · ACS Nano · doi:10.1021/acsnano.1c00181 · Cited by 166 · see citing works
Fingerpad‐Inspired Multimodal Electronic Skin for Material Discrimination and Texture Recognition
Lee, G., Son, J. H., Lee, S., Kim, S. W., Kim, D., Nguyen, N. N., Lee, S. G., & Cho, K. (2021) · Advanced Science · doi:10.1002/advs.202002606 · Cited by 153 · see citing works
The cellular and molecular basis of somatosensory neuron development
Meltzer, S., Santiago, C., Sharma, N., & Ginty, D. D. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.004 · Cited by 149 · see citing works
A Functional Topographic Map for Spinal Sensorimotor Reflexes
Gatto, G., Bourane, S., Ren, X., Di Costanzo, S., Fenton, P. K., Halder, P., Seal, R. P., & Goulding, M. D. (2021) · Neuron · doi:10.1016/j.neuron.2020.10.003 · Cited by 92 · see citing works
“The cutaneous somatosensory system detects a variety of sensory modalities including touch, temperature, pain and itch, which are processed by circuits in the dorsal horn of the spinal cord and medulla (Abraira and Ginty, 2013; Braz et al., 2014; Gatto et al., 2019; Han and Dong, 2014; Jenkins and Lumpkin, 2017; Moehr…”
Background
Bio-inspired artificial mechanoreceptors with built-in synaptic functions for intelligent tactile skin
Hong, S. J., Lee, Y. R., Bag, A., Kim, H. S., Trung, T. Q., Sultan, M. J., Moon, D., & Lee, N. (2025) · Nature Materials · doi:10.1038/s41563-025-02204-y · Cited by 89 · see citing works
“1a,b and Supplementary Note 1) 6,7,10 .”
Molecular and spatial landmarks of early mouse skin development
Jacob, T., Annusver, K., Czarnewski, P., Dalessandri, T., Kalk, C., Levron, C. L., Sanz, N. C., Kastriti, M. E., Mikkola, M. L., Rendl, M., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.07.015 · Cited by 74 · see citing works
Fish Scales Dictate the Pattern of Adult Skin Innervation and Vascularization
Rasmussen, J. P., Vo, N.-T., & Sagasti, A. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.06.019 · Cited by 69 · see citing works
“As embryos develop from embryonic to juvenile and adult forms, the skin undergoes dramatic growth and remodeling, requiring concomitant reorganization of the cutaneous blood vessels and sensory endings mediating touch (Jenkins and Lumpkin, 2017).”
Functional organization and connectivity of the dorsal column nuclei complex reveals a sensorimotor integration and distribution hub
Loutit, A. J., Vickery, R. M., & Potas, J. R. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24942 · Cited by 51 · see citing works
“Other Aβ FA and SA fibers associate with hair follicles with longitudinal lanceolate endings and Merkel cell complexes, respectively (Abraira & Ginty, 2013; Jenkins & Lumpkin, 2017; Li et al., 2011).”
Background
Bridging skin, brain, and behavior to understand pleasurable social touch
Elias, L. J., & Abdus-Saboor, I. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102527 · Cited by 48 · see citing works
Peripheral Somatosensory Neuron Dysfunction: Emerging Roles in Autism Spectrum Disorders
Orefice, L. L. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.01.039 · Cited by 48 · see citing works
“Activation of sensory neuron endings in the periphery leads to signals propagated through their axons, up to their cell bodies, which are located in the dorsal root ganglia (DRG) or cranial sensory ganglia just outside the spinal cord (Jenkins and Lumpkin, 2017).”
Background
FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
Nguyen, M. B., Cohen, I., Kumar, V., Xu, Z., Bar, C., Dauber-Decker, K. L., Tsai, P.-C., Marangoni, P., Klein, O. D., Hsu, Y., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04399-y · Cited by 45 · see citing works
γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons
Meltzer, S., Boulanger, K. C., Chirila, A. M., Osei-Asante, E., DeLisle, M. M., Zhang, Q., Kalish, B. T., Tasnim, A., Huey, E. L., Fuller, L. C., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.03.012 · Cited by 40 · see citing works
Physical contact in parent-infant relationship and its effect on fostering a feeling of safety
Yoshida, S., & Funato, H. (2021) · iScience · doi:10.1016/j.isci.2021.102721 · Cited by 41 · see citing works
Development of tactile sensory circuits in the CNS
Iwasato, T., & Erzurumlu, R. S. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.06.001 · Cited by 37 · see citing works
A cutaneous mechanoneural interface for neuroprosthetic feedback
Srinivasan, S. S., & Herr, H. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-020-00669-7 · Cited by 37 · see citing works
Hair-bearing human skin generated entirely from pluripotent stem cellsPreprint
Lee, J., Rabbani, C. C., Gao, H., Steinhart, M. R., Woodruff, B. M., Pflum, Z. E., Kim, A., Heller, S., Liu, Y., Shipchandler, T. Z., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/684282 · Cited by 31 · see citing works
Embedded real-time objects’ hardness classification for robotic grippers
Amin, Y., Gianoglio, C., & Valle, M. (2023) · Future Generation Computer Systems · doi:10.1016/j.future.2023.06.002 · Cited by 30 · see citing works
Gentle as a mother's touch: C-tactile touch promotes autonomic regulation in preterm infants
Püschel, I., Reichert, J., Friedrich, Y., Bergander, J., Weidner, K., & Croy, I. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113991 · Cited by 28 · see citing works
“The sense of touch is among the earliest sensory modalities to develop with somatosensory neurons arising from the neural crest and undergoing transcription factor-dependent specification within the first trimester of pregnancy [66].”
3D bioprinted human iPSC-derived somatosensory constructs with functional and highly purified sensory neuron networks
Hirano, M., Huang, Y., Jarquin, D. V., Hernández, R. L. D. L. G., Jodat, Y. A., Ceron, E. L., García‐Rivera, L. E., & Shin, S. R. (2021) · Biofabrication · doi:10.1088/1758-5090/abff11 · Cited by 28 · see citing works
Mechanical stimulation of human hair follicle outer root sheath cultures activates adjacent sensory neurons
Agramunt, J., Parke, B., Mena, S., et al. (2023) · Science Advances · doi:10.1126/sciadv.adh3273 · Cited by 25 · see citing works
“First, to investigate LTMR innervation, we used an antibody against the neuronal marker neurofilament heavy (NFH) chain, which is expressed in circumferential and longitudinal large and medium diameter LTMRs ( 20 ), combined with an S100 antibody, which binds to myelin-forming Schwann cells (Fig.”
Method
Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells
Brown, T. L., Horton, E. C., Craig, E. W., Hewitt, M. N., Yee, N. G., Goo, C. E. A., Fan, E. T., Black, E. C., Raible, D. W., & Rasmussen, J. P. (2023) · eLife · doi:10.7554/elife.85800 · Cited by 18 · see citing works
A role for axon–glial interactions and Netrin-G1 signaling in the formation of low-threshold mechanoreceptor end organs
Meltzer, S., Boulanger, K. C., Osei-Asante, E., Handler, A., Zhang, Q., Sano, C., Itohara, S., & Ginty, D. D. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2210421119 · Cited by 17 · see citing works
How do red-eyed treefrog embryos sense motion in predator attacks? Assessing the role of vestibular mechanoreception
Jung, J., Kim, S. J., Arias, S. M. P., et al. (2019) · Journal of Experimental Biology · doi:10.1242/jeb.206052 · Cited by 16 · see citing works
“Since all 499 somatosensory neurons arise from precursor neural crest cells early in embryonic development, 500 much prior to the development of the vestibular system (Jenkins and Lumpkin, 2017; Weston, 501 1970), pre-VOR A.”
Background
Evolution of touch and proprioception of the limbs: Insights from fish and humans
Hale, M. E. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.08.009 · Cited by 15 · see citing works
Activity-dependent development of the body’s touch receptors
Santiago, C., Siegrist, J., Africawala, N., Handler, A., Tasnim, A., Anjum, R., Turecek, J., Lehnert, B. P., Renauld, S., Choi, J., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.04.015 · Cited by 16 · see citing works
Co-option of epidermal cells enables touch sensing
Mangione, F., Titlow, J., Maclachlan, C., Gho, M., Davis, I., Collinson, L., & Tapon, N. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01110-2 · Cited by 13 · see citing works
“Therefore, tactile bristles that lack F-Cells show abnormal mechanotransduction.”
The mechanical forces that shape our senses
Le, A. P., Kim, J., & Koehler, K. R. (2022) · Development · doi:10.1242/dev.197947 · Cited by 11 · see citing works
Immunohistochemical and Genetic Labeling of Hairy and Glabrous Skin Innervation
Pomaville, M. B., & Wright, K. M. (2021) · Current Protocols · doi:10.1002/cpz1.121 · Cited by 12 · see citing works
Histological and ultrastructural characterization of the dorso-ventral skin of the juvenile and the adult starry puffer fish (Arothron stellatus, Anonymous 1798)
Madkour, F. A., Abdellatif, A. M., Osman, Y. A. A., & Kandyel, R. (2023) · BMC Veterinary Research · doi:10.1186/s12917-023-03784-0 · Cited by 11 · see citing works
“The epidermis maturates from a simple mono-or bi-layered epithelium to a stratified multi-layer epithelium, appearance of specialized dermal appendages such as scales, development of dermal vasculature, and highly expands of the skin area [28, 29].”
Background
A Comparison of Hugging Frequency and Its Association with Momentary Mood Before and During COVID-19 Using Ecological Momentary Assessment
Packheiser, J., Sommer, L., Wüllner, M., Malek, I. M., Reichart, J. S., Katona, L., Luhmann, M., & Ocklenburg, S. (2023) · Health Communication · doi:10.1080/10410236.2023.2198058 · Cited by 12 · see citing works
Identification of touch neurons underlying dopaminergic pleasurable touch and sexual receptivityPreprint
Elias, L. J., Schaffler, M. D., Succi, I., Foster, W., Gradwell, M. A., Bohic, M., Ejoh, L. L., Abraira, V. E., & Abdus-Saboor, I. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.22.461355 · Cited by 10 · see citing works
Positive and negative touch differentially modulate metacognitive memory judgements for emotional stimuli.
Convertino, G., Talbot, J., Stockner, M., Gatti, D., Marchetti, M., Mitaritonna, D., & Mazzoni, G. (2024) · British Journal of Psychology · doi:10.1111/bjop.12733 · Cited by 9 · see citing works
Comfort evaluation and physiological effects/autonomic nervous system response of inflatable deep pressure vest in reducing anxiety
Maula, M. I., Ammarullah, M. I., Fadhila, H. N., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e36065 · Cited by 9 · see citing works
“The sense of touch plays a crucial role in human development and daily life and contributes to cognitive and social brain development [1,2].”
Background
Electromechanical model for object roughness perception during finger sliding
Mao, F., Yang, Y., & Jiang, H. (2022) · Biophysical Journal · doi:10.1016/j.bpj.2022.09.014 · Cited by 9 · see citing works
Making developmental sense of the senses, their origin and function
Edens, B. M., & Bronner-Fraser, M. E. (2024) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2024.01.015 · Cited by 8 · see citing works
Molecular regulation of axon termination in mechanosensory neurons
Desbois, M., & Grill, B. J. (2024) · Development · doi:10.1242/dev.202945 · Cited by 8 · see citing works
Aberrant early growth of individual trigeminal sensory and motor axons in a series of mouse genetic models of 22q11.2 deletion syndrome
Motahari, Z., Maynard, T. M., Popratiloff, A. S., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa199 · Cited by 8 · see citing works
The role of interface geometry and appendages on the mesoscale mechanics of the skin
Moreno-Flores, O., Rausch, M. K., & Tepole, A. B. (2023) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-023-01791-6 · Cited by 7 · see citing works
“However, the bulb region of the hair follicle also showed strain concentrations, particularly under shear, but this region is not a primary locus of mechanoreceptors (Jenkins and Lumpkin 2017).”
Mechanical Properties of the Skin: What do we Know?
Ita, K. B., Silva, M., & Bassey, R. B. (2022) · Current Cosmetic Science · doi:10.2174/2666779701666220107161901 · Cited by 7 · see citing works
A bending fluctuation-based mechanism for particle detection by ciliated structures
Thomazo, J.-B., Révérend, B. L., Pontani, L.-L., Prevost, A. M., & Wandersman, É. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2020402118 · Cited by 7 · see citing works
Influence of preload control on friction force measurement of fabric samples
Sümer, B. (2018) · Tribology International · doi:10.1016/j.triboint.2018.06.007 · Cited by 7 · see citing works
Functional Organisation and Connectivity of the Dorsal Column Nuclei Complex Reveals a Sensorimotor Integration and Distribution HubPreprint
Loutit, A. J., Vickery, R. M., & Potas, J. R. (2020) · Preprints.org · doi:10.20944/preprints201911.0084.v3 · Cited by 7 · see citing works
Testing individual variations of horses’ tactile reactivity: when, where, how?
Gueguen, L., Lerch, N., Grandgeorge, M., et al. (2022) · Die Naturwissenschaften · doi:10.1007/s00114-022-01811-y · Cited by 6 · see citing works
“The nerve endings of these receptors convert these stimuli into nerve impulses (Jenkins and Lumpkin 2017).”
Background
The insulin receptor regulates the persistence of mechanical nociceptive sensitization in flies and mice
Wang, Y., Lopez-Bellido, R., Huo, X., et al. (2023) · Biology Open · doi:10.1242/bio.059864 · Cited by 5 · see citing works
“First, the architecture of nociceptive sensory neurons in mice is more diverse, with a more clear physical and functional separation between neurons mediating thermal and mechanical responses (Jenkins and Lumpkin, 2017; Le Pichon and Chesler, 2014).”
Background
Functional Connectivity Evoked by Orofacial Tactile Perception of Velocity
Wang, Y., Sibaii, F., Custead, R., Oh, H., & Barlow, S. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00182 · Cited by 5 · see citing works
“Tactile sensation is detected by cutaneous mechanoreceptors in the skin and is then projected to afferent neurons or sensory nerves, via the spinal cord, toward the central nervous system (Jenkins and Lumpkin, 2017).”
Background
Fava Bean Protein Nanofibrils Modulate Cell Membrane Interfaces for Biomolecular Interactions as Unveiled by Atomic Force Microscopy
Karanth, S., Wiesenfarth, M., Benthin, J., & Koehler, M. (2024) · Foods · doi:10.3390/foods13213411 · Cited by 4 · see citing works
“The Merkel carcinoma cell (MCC-13) line is a well-established model cell line for transducing biological signals due to touch sen-Foods sation [28,29].”
Background
Interlocking host and viral cis-regulatory networks drive Merkel cell carcinoma
Miao, L., Milewski, D., Coxon, A. B., Gelb, T., Garman, K. A., Porch, J., Khanna, A., Collado, L., Hill, N. T., Daily, K., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci188924 · Cited by 4 · see citing works
“Merkel cells and sensory hair cells of the inner ear are inner-vated mechanoreceptors, and both require ATOH1 and SOX2 for proper development (12).”
A Multi-Systems Approach to Human Movement after ACL Reconstruction: The Integumentary System
Lucas, K. C. H., Todd, P. S., & Ness, B. M. (2021) · International Journal of Sports Physical Therapy · doi:10.26603/001c.29454 · Cited by 4 · see citing works
How Merkel cells transduce mechanical stimuli: A biophysical model of Merkel cells
Mao, F., & Yang, W. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011720 · Cited by 4 · see citing works
Ferroelectric‐Assisted Ion Dynamics for Prolonged Tactile Cognizance in a Biomimetic Memory‐in‐Sensor System
Bhunia, R., Kim, J. S., Oh, H., Kim, D. J., Lee, S., Park, C., & Kim, D. H. (2024) · Advanced Electronic Materials · doi:10.1002/aelm.202400550 · Cited by 4 · see citing works
Distinct patterns of activity in individual cortical neurons and local networks in primary somatosensory cortex of mice evoked by square-wave mechanical limb stimulation
Bandet, M. V., Dong, B., & Winship, I. R. (2021) · PLoS ONE · doi:10.1371/journal.pone.0236684 · Cited by 2 · see citing works
TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by NTRK Fusions
Cappellesso, R., Nicolè, L., Fiore, P. D., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315366 · Cited by 3 · see citing works
“Neurotrophin signaling seems to play a key role in recruiting afferents to Merkel cell-enriched skin areas and in the development and maintenance of touch receptors [40,41].”
Background
Trauma and Sensory Systems: Biological Mechanisms Involving the Skin and the 17q21 Gene Cluster
Korgan, A. C., Prendergast, K., Rosenhauer, A. M., Morrison, K. E., Jovanović, T., & Bale, T. L. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.11.003 · Cited by 3 · see citing works
Automated Benchmarking of Variable‐Property Soft Robotic Fingertips to Enable Task‐Optimized Sensor Selection
Hardman, D. K., Dai, B., Guan, Q., et al. (2025) · Advanced Science · doi:10.1002/advs.202509991 · Cited by 2 · see citing works
Development of vertebrate cutaneous end-organ complexes
Vega, J. A., García‐Mesa, Y., Cuendias, P., Martín‐Cruces, J., Cobo, R., García‐Piqueras, J., Galdames, I. S., & García‐Suárez, O. (2025) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2025.03.001 · Cited by 3 · see citing works
Neuroanatomy, Touch Receptor
Whitehead, C., & Grider, M. H. (2021) · StatPearls · Cited by 2 · see citing works
Touch-driven advantages in reaction time but not in performance in a cross-sensory comparison of reinforcement learning
Sun, W., Ripp, I., Borrmann, A., Moll, M., & Fairhurst, M. T. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e41330 · Cited by 1 · see citing works
“Jenkins and Lumpkin [10] characterise touch as the most intimate sense, implying that humans may have evolved to depend more on touch when visual or auditory information is ambiguous, leading to a greater innate sense of confidence in touch-based tasks [1].”
Merkel cell stimulation in fear and sensory signaling
Korgan, A. C., Orso, R., Sibley, I. J., Prendergast, K., Jovanović, T., & Bale, T. L. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02144-w · Cited by 1 · see citing works
Organic electrochemical transistor‐based tactile perception: From sensing to neuromorphic processing
Zhang, X., Zeng, D., Zhang, R., et al. (2026) · InfoMat · doi:10.1002/inf2.70165 · Cited by 1 · see citing works
Türk Ceza Kanununda Yer Alan Duyularından veya Organlarından Birinin İşlevinin Sürekli Zayıflaması veya Yitirilmesi Kavramları: Sistematik Derleme
Çeli̇k, C., & Ata, U. (2022) · The Bulletin of Legal Medicine · doi:10.17986/blm.1585 · Cited by 1 · see citing works
The Dorsal Column Nuclei Neuroanatomy Reveals A Complex Sensorimotor Integration and Distribution HubPreprint
Loutit, A. J., Vickery, R. M., & Potas, J. R. (2019) · Preprints.org · doi:10.20944/preprints201911.0084.v1 · Cited by 1 · see citing works
“Other Aβ FA and SA fibres associate with hair follicles with longitudinal lanceolate endings and Merkel cell complexes, respectively (Abraira & Ginty, 2013; Jenkins & Lumpkin, 2017; L. Li et al., 2011).”
Background
The laboratory mouse
Pritchett‐Corning, K. R., & Garner, J. P. (2024) · Wiley eBooks · doi:10.1002/9781119555278.ch21 · Cited by 1 · see citing works
Interacting with the environment receiving and interpreting signals
Smith, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819613-7.00001-3
The Dorsal Column Nuclei Complex Neuroanatomy Reveals a Complex Sensorimotor Integration and Distribution HubPreprint
Loutit, A. J., Vickery, R. M., & Potas, J. R. (2020) · Preprints.org · doi:10.20944/preprints201911.0084.v2
A new cell in an old tactile sensory organ
Zhu, R., & Jan, Y. N. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01119-7
Sensory Modality Influence on Human Reinforcement Learning: Different Response Time but Consistent PerformancePreprint
Sun, W., Ripp, I., Borrmann, A., Moll, M., & Fairhurst, M. T. (2023) · Research Square · doi:10.21203/rs.3.rs-3714585/v1
Touch-Driven Advantages in Reaction Time but not Performance in a Cross-Sensory Comparison of Reinforcement LearningPreprint
Sun, W., Ripp, I., Borrmann, A., Moll, M., & Fairhurst, M. T. (2024) · Research Square · doi:10.21203/rs.3.rs-3714585/v2
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Authors: Jenkins, B. A., & Lumpkin, E. A.
Affiliations: Columbia University Irving Medical Center (US)
Corresponding author: Jenkins, Blair A.
ORCID: Jenkins, Blair A.
Lumpkin, Ellen A.
Venue: Development
Publisher: The Company of Biologists
Published: 2017-11-15
Volume: 144
Issue: 22
Pages: 4078-4090
ISSN: 0950-1991 (ISSN-L)
1477-9129
DOI: 10.1242/dev.120402
PMC: PMC5719243
OpenAlex: W2769136057
Semantic Scholar: 07f6a4f9aaff022f18907861a69faf984c18096e
Cited by: 79
References: 207
Citations by year: 2026: 7 · 2025: 8 · 2024: 11 · 2023: 14 · 2022: 9 · 2021: 13 · 2020: 10 · 2019: 3 · 2018: 4
FWCI: 0.52
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.biologists.com/user-licence-1-1 (vor, 181 d)
Locations: Development (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: National Institute of Neurological Disorders and Stroke (F31NS094023, R01NS073119)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR051219)
National Institute of General Medical Sciences (T32GM007367)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Keywords: mechanosensory neurons, tactile perception, skin development, embryonic development, axon guidance, skin epithelium, peripheral nervous system development
MeSH terms: Animals, Humans, Mechanoreceptors, Neurons, Sensation, Skin, Touch, Body Patterning

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