The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Msx homeobox genes inhibit differentiation through upregulation of cyclin D1
Abstract
During development, patterning and morphogenesis of tissues are intimately coordinated through control of cellular proliferation and differentiation. We describe a mechanism by which vertebrate Msx homeobox genes inhibit cellular differentiation by regulation of the cell cycle. We show that misexpression of Msx1 via retroviral gene transfer inhibits differentiation of multiple mesenchymal and epithelial progenitor cell types in culture. This activity of Msx1 is associated with its ability to upregulate cyclin D1 expression and Cdk4 activity, while Msx1 has minimal effects on cellular proliferation. Transgenic mice that express Msx1 under the control of the mouse mammary tumor virus long terminal repeat (MMTV LTR) display impaired differentiation of the mammary epithelium during pregnancy, which is accompanied by elevated levels of cyclin D1 expression. We propose that Msx1 gene expression maintains cyclin D1 expression and prevents exit from the cell cycle, thereby inhibiting terminal differentiation of progenitor cells. Our model provides a framework for reconciling the mutant phenotypes of Msx and other homeobox genes with their functions as regulators of cellular proliferation and differentiation during embryogenesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer
(1996) · Advances in cancer research · doi:10.1016/s0065-230x(08)60352-8 · Cited by 752
Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
Satokata, I., Ma, L., Ohshima, H., Bei, M., Woo, I., Nishizawa, K., Maeda, T., Takano, Y., Uchiyama, M., Heaney, S., et al. (2000) · Nature Genetics · doi:10.1038/74231 · Cited by 737
Functional haploinsufficiency of the human homeobox gene MSX2 causes defects in skull ossification
Wilkie, A. O. M., Tang, Z., Elanko, N., Walsh, S., Twigg, S. R. F., Hurst, J. A., Wall, S. A., Chrzanowska, K. H., & Maxson, R. E. (2000) · Nature Genetics · doi:10.1038/74224 · Cited by 315
Cited by
Cranial neural crest and the building of the vertebrate head
Santagati, F., & Rijli, F. M. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1221 · Cited by 461
Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling
Kielman, M. F., Rindapää, M., Gaspar, C., van Poppel, N., Breukel, C., van Leeuwen, S., Taketo, M. M., Roberts, S., Smits, R., & Fodde, R. (2002) · Nature Genetics · doi:10.1038/ng1045 · Cited by 362
Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects
Ito, Y., Yeo, J. Y., Chytil, A., Han, J., Bringas, P., Nakajima, A., Shuler, C. F., Moses, H. L., & Chai, Y. (2003) · Development · doi:10.1242/dev.00708 · Cited by 349
Mechanisms of pattern formation in development and evolution
Salazar-Ciudad, I., Jernvall, J., & Newman, S. A. (2003) · Development · doi:10.1242/dev.00425 · Cited by 334
Old questions, new tools, and some answers to the mystery of fin regeneration
Akimenko, M., Marí‐Beffa, M., Becerra, J., & Géraudie, J. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10248 · Cited by 316
Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate
Jezewski, P. A., Vieira, A. R., Nishimura, C., Ludwig, B., Johnson, M., O’Brien, S. E., Daack-Hirsch, S., Schultz, R. E., Weber, A., Nepomucena, B., et al. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.6.399 · Cited by 304
Evolution of striated muscle: Jellyfish and the origin of triploblasty
Seipel, K., & Schmid, V. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.03.032 · Cited by 172
Dlx homeobox gene family expression in osteoclasts
Lézot, F., Thomas, B. L., Blin‐Wakkach, C., Castaneda, B., Bolanos, A., Hotton, D., Sharpe, P. T., Heymann, D., Carles, G. F., Grigoriadis, A. E., et al. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22095 · Cited by 24
Metadata
- Authors
- Hu, G., Lee, H., Price, S. M., Shen, M. M., & Abate-Shen, C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2001-06-15
- Volume
- 128
- Issue
- 12
- Pages
- 2373-2384
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2126158230
- Cited by
- 209
- References
- 3
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
