The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants
Abstract
In both Drosophila and vertebrates, spatially restricted expression of HOX genes is controlled by the Polycomb group (PcG) repressors. Here we characterize a novel Drosophila PcG gene, Suppressor of zeste 12 (Su(z)12). Su(z)12 mutants exhibit very strong homeotic transformations and Su(z)12 function is required throughout development to maintain the repressed state of HOX genes. Unlike most other PcG mutations, Su(z)12 mutations are strong suppressors of position-effect variegation (PEV), suggesting that Su(z)12 also functions in heterochromatin-mediated repression. Furthermore, Su(z)12 function is required for germ cell development. The Su(z)12 protein is highly conserved in vertebrates and is related to the Arabidopsis proteins EMF2, FIS2 and VRN2. Notably, EMF2 is a repressor of floral homeotic genes. These results suggest that at least some of the regulatory machinery that controls homeotic gene expression is conserved between animals and plants.
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Cites
Segmental distribution of bithorax complex proteins during Drosophila development
Beachy, P. A., Helfand, S. L., & Hogness, D. S. (1985) · Nature · doi:10.1038/313545a0 · Cited by 413
Functional analysis of mouse Polycomb group genes.
van Lohuizen, M. (1998) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s000180050126 · Cited by 79
Cited by
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R. S., & Zhang, Y. (2002) · Science · doi:10.1126/science.1076997 · Cited by 3,775
Kuzmichev, A., Nishioka, K., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (2002) · Genes & Development · doi:10.1101/gad.1035902 · Cited by 1,596
Czermin, B., Melfi, R., McCabe, D., Seitz, V., Imhof, A., & Pirrotta, V. (2002) · Cell · doi:10.1016/s0092-8674(02)00975-3 · Cited by 1,533
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
Pasini, D., Bracken, A. P., Jensen, M. R., Denchi, E. L., & Helin, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600402 · Cited by 916
The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation
Pasini, D., Bracken, A. P., Hansen, J. B., Capillo, M., & Helin, K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01432-06 · Cited by 696
Metadata
- Authors
- Birve, A., Sengupta, A. K., Beuchle, D., Larsson, J., Kennison, J. A., Rasmuson-Lestander, A., & Müller, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2001-09-01
- Volume
- 128
- Issue
- 17
- Pages
- 3371-3379
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2119938322
- Cited by
- 216
- References
- 2
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- closed
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