The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants
Abstract
In both Drosophila and vertebrates, spatially restricted expression of HOX genes is controlled by the Polycomb group (PcG) repressors. Here we characterize a novel Drosophila PcG gene, Suppressor of zeste 12 (Su(z)12). Su(z)12 mutants exhibit very strong homeotic transformations and Su(z)12 function is required throughout development to maintain the repressed state of HOX genes. Unlike most other PcG mutations, Su(z)12 mutations are strong suppressors of position-effect variegation (PEV), suggesting that Su(z)12 also functions in heterochromatin-mediated repression. Furthermore, Su(z)12 function is required for germ cell development. The Su(z)12 protein is highly conserved in vertebrates and is related to the Arabidopsis proteins EMF2, FIS2 and VRN2. Notably, EMF2 is a repressor of floral homeotic genes. These results suggest that at least some of the regulatory machinery that controls homeotic gene expression is conserved between animals and plants.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Segmental distribution of bithorax complex proteins during Drosophila development
Beachy, P. A., Helfand, S. L., & Hogness, D. S. (1985) · Nature · doi:10.1038/313545a0 · Cited by 413
Functional analysis of mouse Polycomb group genes.
van Lohuizen, M. (1998) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s000180050126 · Cited by 79
Cited by
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R. S., & Zhang, Y. (2002) · Science · doi:10.1126/science.1076997 · Cited by 3,775
Kuzmichev, A., Nishioka, K., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (2002) · Genes & Development · doi:10.1101/gad.1035902 · Cited by 1,596
Czermin, B., Melfi, R., McCabe, D., Seitz, V., Imhof, A., & Pirrotta, V. (2002) · Cell · doi:10.1016/s0092-8674(02)00975-3 · Cited by 1,533
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
Pasini, D., Bracken, A. P., Jensen, M. R., Denchi, E. L., & Helin, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600402 · Cited by 916
The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation
Pasini, D., Bracken, A. P., Hansen, J. B., Capillo, M., & Helin, K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01432-06 · Cited by 696
The Timing of Developmental Transitions in Plants
Bäurle, I., & Dean, C. (2006) · Cell · doi:10.1016/j.cell.2006.05.005 · Cited by 657
Functions and mechanisms of epigenetic inheritance in animals
Skvortsova, K., Iovino, N., & Bogdanović, O. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0074-2 · Cited by 517
Iliopoulos, D., Lindahl-Allen, M., Polytarchou, C., Hirsch, H. A., Tsichlis, P. N., & Struhl, K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.013 · Cited by 399
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing
Schoeftner, S., Sengupta, A. K., Kubicek, S., Mechtler, K., Spahn, L., Koseki, H., Jenuwein, T., & Wutz, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601187 · Cited by 398
Self-citationH3K27 methylation: a promiscuous repressive chromatin mark
Wiles, E. T., & Selker, E. U. (2017) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.11.001 · Cited by 331
Endosperm: the crossroad of seed development
Berger, F. (2003) · Current Opinion in Plant Biology · doi:10.1016/s1369526602000043 · Cited by 269
Liu, Y., Taverna, S. D., Muratore, T. L., Shabanowitz, J., Hunt, D. F., & Allis, C. D. (2007) · Genes & Development · doi:10.1101/gad.1544207 · Cited by 257
Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene
Coleman, R. T., & Struhl, G. (2017) · Science · doi:10.1126/science.aai8236 · Cited by 221
Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance
Siebold, A. P., Banerjee, R., Tie, F., Kiss, D. L., Moskowitz, J., & Harte, P. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907739107 · Cited by 216
Kennerdell, J. R., Liu, N., & Bonini, N. M. (2018) · Nature Communications · doi:10.1038/s41467-018-06592-5 · Cited by 56
Zhu, X., Sen, J., Stevens, L., Goltz, J. S., & Stein, D. (2005) · Development · doi:10.1242/dev.01962 · Cited by 37
Caenorhabditis elegans MES-3 is a highly divergent ortholog of the canonical PRC2 component SUZ12
Snel, B., van den Heuvel, S., & Seidl, M. F. (2022) · iScience · doi:10.1016/j.isci.2022.104633 · Cited by 8
Metadata
- Authors
- Birve, A., Sengupta, A. K., Beuchle, D., Larsson, J., Kennison, J. A., Rasmuson-Lestander, A., & Müller, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2001-09-01
- Volume
- 128
- Issue
- 17
- Pages
- 3371-3379
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2119938322
- Cited by
- 216
- References
- 2
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
