The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A morphogen gradient of Wnt/β-catenin signalling regulates anteroposterior neural patterning in Xenopus
Abstract
Anteroposterior (AP) patterning of the vertebrate neural plate is initiated during gastrulation and is regulated by Spemann’s organizer and its derivatives. The prevailing model for AP patterning predicts a caudally increasing gradient of a ‘transformer’ which posteriorizes anteriorly specified neural cells. However, the molecular identity of the transforming gradient has remained elusive. We show that in Xenopus embryos (1) dose-dependent Wnt signalling is both necessary and sufficient for AP patterning of the neuraxis, (2) Wnt/β-catenin signalling occurs in a direct and long-range fashion within the ectoderm, and (3) that there is an endogenous AP gradient of Wnt/β-catenin signalling in the presumptive neural plate of the Xenopus gastrula. Our results indicate that an activity gradient of Wnt/β-catenin signalling acts as transforming morphogen to pattern the Xenopus central nervous system.
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Cites
Bouwmeester, T., Kim, S.-H., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Nature · doi:10.1038/382595a0 · Cited by 759
The establishment of spemann's organizer and patterning of the vertebrate embryo
De Robertis, E. M., Larraín, J., Oelgeschläger, M., & Wessely, O. (2000) · Nature Reviews Genetics · doi:10.1038/35042039 · Cited by 429
Cited by
WNTS in the vertebrate nervous system: from patterning to neuronal connectivity
Ciani, L., & Salinas, P. C. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1665 · Cited by 543
Visualization of a short-range Wnt gradient in the intestinal stem-cell niche
Farin, H. F., Jordens, I., Mosa, M. H., Basak, O., Korving, J., Tauriello, D. V. F., de Punder, K., Angers, S., Peters, P. J., Maurice, M. M., et al. (2016) · Nature · doi:10.1038/nature16937 · Cited by 525
Requirement of Prorenin Receptor and Vacuolar H + -ATPase–Mediated Acidification for Wnt Signaling
Cruciat, C.-M., Ohkawara, B., Acebron, S. P., Karaulanov, E., Reinhard, C., Ingelfinger, D., Boutros, M., & Niehrs, C. (2010) · Science · doi:10.1126/science.1179802 · Cited by 516
Self-citationCranial neural crest and the building of the vertebrate head
Santagati, F., & Rijli, F. M. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1221 · Cited by 461
R-Spondin2 Is a Secreted Activator of Wnt/β-Catenin Signaling and Is Required for Xenopus Myogenesis
Kazanskaya, O., Glinka, A., del Barco Barrantes, I., Stannek, P., Niehrs, C., & Wu, W. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.07.019 · Cited by 431
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Metadata
- Authors
- Kiecker, C., & Niehrs, C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2001-11-01
- Volume
- 128
- Issue
- 21
- Pages
- 4189-4201
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2102735467
- Cited by
- 512
- References
- 2
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- closed
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