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WNTS in the vertebrate nervous system: from patterning to neuronal connectivity

Ciani, Lorenza, Salinas, Patricia C.·2005·Nature Reviews Neuroscience
DOI 10.1038/nrn1665
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Abstract

WNT signalling has a key role in early embryonic patterning through the regulation of cell fate decisions, tissue polarity and cell movements. In the nervous system, WNT signalling also regulates neuronal connectivity by controlling axon pathfinding, axon remodelling, dendrite morphogenesis and synapse formation. Studies, from invertebrates to mammals, have led to a considerable understanding of WNT signal transduction pathways. This knowledge provides a framework for the study of the mechanisms by which WNTs regulate diverse neuronal functions. Manipulation of the WNT pathways could provide new strategies for nerve regeneration and neuronal circuit modulation.

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  1. Nusse, R. & Varmus, H. E. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31, 99–109 (1982). · DOI
  2. Baker, N. E. Localization of transcripts from the wingless gene in whole Drosophila embryos. Development 103, 289–298 (1988). · DOI
  3. McMahon, A. P. & Moon, R. T. int-1 — a proto-oncogene involved in cell signalling. Development 107 (Suppl.), 161–167 (1989). · DOI
  4. Stern, C. D. Initial patterning of the central nervous system: how many organizers? Nature Rev. Neurosci. 2, 92–98 (2001). · DOI
  5. Kiecker, C. & Niehrs, C. The role of prechordal mesendoderm in neural patterning. Curr. Opin. Neurobiol. 11, 27–33 (2001). · DOI
  6. Bhanot, P. et al. A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 382, 225–230 (1996). · DOI
  7. Yoshikawa, S., McKinnon, R. D., Kokel, M. & Thomas, J. B. Wnt-mediated axon guidance via the Drosophila Derailed receptor. Nature 422, 583–588 (2003). An important paper that presents a novel role for WNT in axon guidance. The D. melanogaster WNT5 functions as a repellent for commissural axons. Importantly, this paper reports for the first time that WNT signals through the atypical receptor tyrosine kinase Derailed rather than FZ receptors. · DOI
  8. Lu, W., Yamamoto, V., Ortega, B. & Baltimore, D. Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119, 97–108 (2004). This paper describes the mechanism through which the atypical receptor tyrosine kinase RYK, the vertebrate homologue of Derailed, functions in mammals. RYK is a coreceptor for FZ receptors and activates the canonical WNT pathway through the DVL protein. · DOI
  9. Inoue, T. et al. C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17/Frizzled in Wnt signaling. Cell 118, 795–806 (2004). The Caenorhabditis elegans lin-18 gene is found to encode a member of the RYK/Derailed family of WNT receptors. lin-18 and lin-17 , a class of FZ receptors, signal through two independent but parallel pathways to regulate cell fate decisions. · DOI
  10. Krylova, O., Messenger, M. J. & Salinas, P. C. Dishevelled-1 regulates microtubule stability: a new function mediated by glycogen synthase kinase-3β. J. Cell Biol. 151, 83–94 (2000). · DOI
  11. Ciani, L., Krylova, O., Smalley, M. J., Dale, T. C. & Salinas, P. C. A divergent canonical WNT-signaling pathway regulates microtubule dynamics: Dishevelled signals locally to stabilize microtubules. J. Cell Biol. 164, 243–253 (2004). · DOI
  12. Logan, C. Y. & Nusse, R. The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 20, 781–810 (2004). · DOI · Paper page
  13. Tamai, K. et al. LDL-receptor-related proteins in Wnt signal transduction. Nature 407, 530–535 (2000). · DOI · Paper page
  14. Wehrli, M. et al. arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature 407, 527–530 (2000). · DOI
  15. Pinson, K. I., Brennan, J., Monkley, S., Avery, B. J. & Skarnes, W. C. An LDL-receptor-related protein mediates Wnt signalling in mice. Nature 407, 535–538 (2000). · DOI
  16. Mao, B. et al. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411, 321–325 (2001). · DOI
  17. Semenov, M. V. et al. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr. Biol. 11, 951–961 (2001). · DOI · Paper page
  18. Davidson, G., Mao, B., del Barco Barrantes, I. & Niehrs, C. Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning. Development 129, 5587–5596 (2002). · DOI
  19. Mao, B. et al. Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling. Nature 417, 664–667 (2002). · DOI · Paper page
  20. Huelsken, J. & Birchmeier, W. New aspects of Wnt signaling pathways in higher vertebrates. Curr. Opin. Genet. Dev. 11, 547–553 (2001). · DOI
  21. Strutt, D. I., Weber, U. & Mlodzik, M. The role of RhoA in tissue polarity and Frizzled signalling. Nature 387, 292–295 (1997). · DOI
  22. Dabdoub, A. et al. Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea. Development 130, 2375–2384 (2003). · DOI
  23. Veeman, M. T., Slusarski, D. C., Kaykas, A., Louie, S. H. & Moon, R. T. Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr. Biol. 13, 680–685 (2003). · DOI · Paper page
  24. Kuhl, M., Sheldahl, L. C., Park, M., Miller, J. R. & Moon, R. T. The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet. 16, 279–283 (2000). · DOI
  25. Liu, T. et al. G protein signaling from activated rat frizzled-1 to the β-catenin-Lef-Tcf pathway. Science 292, 1718–1722 (2001). · DOI
  26. Katanaev, V. L., Ponzielli, R., Semeriva, M. & Tomlinson, A. Trimeric G protein-dependent Frizzled signaling in Drosophila. Cell 120, 111–122 (2005). This study shows for the first time that trimeric G proteins are essential for signalling through the WNT pathway. Loss- and gain-of-function studies show that the G 0 subunit acts immediately downstream of FZ and that it is required for downstream signalling events for both the WNT canonical and the PCP pathways in D. melanogaster. · DOI
  27. Nieuwkoop, P. D. Activation and organisation of the central nervous system in amphibians. J. Exp. Zool. 120, 1–108 (1952). · DOI
  28. Kiecker, C. & Niehrs, C. A morphogen gradient of Wnt/β-catenin signalling regulates anteroposterior neural patterning in Xenopus. Development 128, 4189–4201 (2001). This is the first clear demonstration that a gradient of WNT signalling is responsible for the A–P patterning of the neural plate. A specific read-out of WNT activity using levels of β-catenin shows that a WNT morphogen gradient patterns the Xenopus nervous system. · DOI
  29. Nordstrom, U., Jessell, T. M. & Edlund, T. Progressive induction of caudal neural character by graded Wnt signaling. Nature Neurosci. 5, 525–532 (2002). · DOI
  30. McGrew, L. L., Lai, C. J. & Moon, R. T. Specification of the anteroposterior neural axis through synergistic interaction of the Wnt signaling cascade with noggin and follistatin. Dev. Biol. 172, 337–342 (1995). · DOI
  31. McGrew, L. L., Hoppler, S. & Moon, R. T. Wnt and FGF pathways cooperatively pattern anteroposterior neural ectoderm in Xenopus. Mech. Dev. 69, 105–114 (1997). · DOI
  32. Hamilton, F. S., Wheeler, G. N. & Hoppler, S. Difference in XTcf-3 dependency accounts for change in response to β-catenin-mediated Wnt signalling in Xenopus blastula. Development 128, 2063–2073 (2001). · DOI
  33. Darken, R. S. & Wilson, P. A. Axis induction by Wnt signaling: target promoter responsiveness regulates competence. Dev. Biol. 234, 42–54 (2001). · DOI
  34. Lekven, A. C., Thorpe, C. J., Waxman, J. S. & Moon, R. T. Zebrafish wnt8 encodes two Wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning. Dev. Cell 1, 103–114 (2001). · DOI
  35. Erter, C. E., Wilm, T. P., Basler, N., Wright, C. V. & Solnica-Krezel, L. Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo. Development 128, 3571–3583 (2001). · DOI
  36. Glinka, A., Wu, W., Onichtchouk, D., Blumenstock, C. & Niehrs, C. Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus. Nature 389, 517–519 (1997). · DOI
  37. Hashimoto, H. et al. Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation. Dev. Biol. 217, 138–152 (2000). · DOI
  38. Glinka, A. et al. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391, 357–362 (1998). · DOI · Paper page
  39. Kazanskaya, O., Glinka, A. & Niehrs, C. The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning. Development 127, 4981–4992 (2000). · DOI
  40. Mukhopadhyay, M. et al. Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev. Cell 1, 423–434 (2001). This paper shows that the WNT repressor DKK1 is required for the formation of the head in Xenopus . Analysis of Dkk1 mouse mutant embryos reveals loss of structures anterior to the midbrain and expansion of posterior characteristics. In addition, this mutant has a limb phenotype that indicates a role for DKK1 in cell proliferation and programmed cell death, in which WNT signalling is also involved. · DOI
  41. MacDonald, B. T., Adamska, M. & Meisler, M. H. Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6. Development 131, 2543–2552 (2004). · DOI
  42. Leyns, L., Bouwmeester, T., Kim, S. H., Piccolo, S. & De Robertis, E. M. Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell 88, 747–756 (1997). · DOI
  43. Belo, J. A. et al. Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development. Genesis 26, 265–270 (2000). · DOI
  44. Shawlot, W., Min Deng, J., Wakamiya, M. & Behringer, R. R. The cerberus-related gene, Cerr1, is not essential for mouse head formation. Genesis 26, 253–258 (2000). · DOI
  45. Stanley, E. G. et al. Targeted insertion of a lacZ reporter gene into the mouse Cer1 locus reveals complex and dynamic expression during embryogenesis. Genesis 26, 259–264 (2000). · DOI
  46. Yamaguchi, Y. & Shinagawa, A. Marked alteration at midblastula transition in the effect of lithium on formation of the larval body pattern of Xenopus laevis. Dev. Growth Diff. 31, 531–541 (1989). · DOI
  47. Kim, C. H. et al. Repressor activity of Headless/Tcf3 is essential for vertebrate head formation. Nature 407, 913–916 (2000). · DOI
  48. Dorsky, R. I., Itoh, M., Moon, R. T. & Chitnis, A. Two tcf3 genes cooperate to pattern the zebrafish brain. Development 130, 1937–1947 (2003). · DOI
  49. Wilson, S. W. & Houart, C. Early steps in the development of the forebrain. Dev. Cell 6, 167–181 (2004). · DOI
  50. Heisenberg, C. P. et al. A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes Dev. 15, 1427–1434 (2001). · DOI
  51. van de Water, S. et al. Ectopic Wnt signal determines the eyeless phenotype of zebrafish masterblind mutant. Development 128, 3877–3888 (2001). · DOI
  52. Houart, C. et al. Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron 35, 255–265 (2002). A new secreted Wnt antagonist, Tlc, which belongs to the family of secreted Frizzled-related (Sfrp) Wnt antagonists, is found to be expressed in the anterior boundary of the neural plate in zebrafish. Tlc induces the expression of telencephalic markers in a concentration-dependent manner. The data also indicate that Wnt8b, which is expressed in the prospective caudal diencephalon and midbrain, is a likely target for Tlc. So, a balance between Wnts and their antagonists patterns the telecephalon. · DOI
  53. Braun, M. M., Etheridge, A., Bernard, A., Robertson, C. P. & Roelink, H. Wnt signaling is required at distinct stages of development for the induction of the posterior forebrain. Development 130, 5579–5587 (2003). · DOI
  54. Buckles, G. R., Thorpe, C. J., Ramel, M. C. & Lekven, A. C. Combinatorial Wnt control of zebrafish midbrain–hindbrain boundary formation. Mech. Dev. 121, 437–447 (2004). · DOI
  55. Lagutin, O. V. et al. Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev. 17, 368–379 (2003). · DOI
  56. Loosli, F., Winkler, S. & Wittbrodt, J. Six3 overexpression initiates the formation of ectopic retina. Genes Dev. 13, 649–654 (1999). · DOI
  57. Carl, M., Loosli, F. & Wittbrodt, J. Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye. Development 129, 4057–4063 (2002). · DOI
  58. Kobayashi, M., Toyama, R., Takeda, H., Dawid, I. B. & Kawakami, K. Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish. Development 125, 2973–2982 (1998). · DOI
  59. Gunhaga, L. et al. Specification of dorsal telencephalic character by sequential Wnt and FGF signaling. Nature Neurosci. 6, 701–707 (2003). · DOI
  60. Hollyday, M., McMahon, J. A. & McMahon, A. P. Wnt expression patterns in chick embryo nervous system. Mech. Dev. 52, 9–25 (1995). · DOI
  61. Mohammadi, M. et al. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science 276, 955–960 (1997). · DOI
  62. Grove, E. A., Tole, S., Limon, J., Yip, L. & Ragsdale, C. W. The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice. Development 125, 2315–2325 (1998). · DOI
  63. Lee, S. M., Tole, S., Grove, E. & McMahon, A. P. A local Wnt-3a signal is required for development of the mammalian hippocampus. Development 127, 457–467 (2000). · DOI
  64. Galceran, J., Miyashita-Lin, E. M., Devaney, E., Rubenstein, J. L. & Grosschedl, R. Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development 127, 469–482 (2000). · DOI
  65. Machon, O., van den Bout, C. J., Backman, M., Kemler, R. & Krauss, S. Role of β-catenin in the developing cortical and hippocampal neuroepithelium. Neuroscience 122, 129–143 (2003). · DOI
  66. Thomas, K. R., Musci, T. S., Neumann, P. E. & Capecchi, M. R. Swaying is a mutant allele of the proto-oncogene Wnt-1. Cell 67, 969–976 (1991). · DOI
  67. McMahon, A. P. & Bradley, A. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62, 1073–1085 (1990). · DOI
  68. Serbedzija, G. N., Dickinson, M. & McMahon, A. P. Cell death in the CNS of the Wnt-1 mutant mouse. J. Neurobiol. 31, 275–282 (1996). · DOI
  69. McMahon, A. P., Joyner, A. L., Bradley, A. & McMahon, J. A. The midbrain–hindbrain phenotype of Wnt-1/Wnt-1 mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. Cell 69, 581–595 (1992). · DOI
  70. Danielian, P. S. & McMahon, A. P. Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature 383, 332–334 (1996). · DOI
  71. Brault, V. et al. Inactivation of the β-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128, 1253–1264 (2001). · DOI
  72. Ye, W. et al. Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8. Nature Neurosci. 4, 1175–1181 (2001). · DOI
  73. Chi, C. L., Martinez, S., Wurst, W. & Martin, G. R. The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum. Development 130, 2633–2644 (2003). · DOI
  74. Trainor, P. A. & Krumlauf, R. Patterning the cranial neural crest: hindbrain segmentation and Hox gene plasticity. Nature Rev. Neurosci. 1, 116–124 (2000). · DOI · Paper page
  75. Lumsden, A. Segmentation and compartition in the early avian hindbrain. Mech. Dev. 121, 1081–1088 (2004). · DOI
  76. Pasini, A. & Wilkinson, D. G. Stabilizing the regionalisation of the developing vertebrate central nervous system. Bioessays 24, 427–438 (2002). · DOI
  77. Riley, B. B. et al. Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain. Dev. Dyn. 231, 278–291 (2004). · DOI
  78. Amoyel, M., Cheng, Y. -C., Jiang, Y. -J. & Wilkinson, D. G. Wnt1 regulates neurogenesis and mediates lateral inhibition of boundary cell specification in the zebrafish hindbrain. Development (in the press).
  79. Gammill, L. S. & Bronner-Fraser, M. Neural crest specification: migrating into genomics. Nature Rev. Neurosci. 4, 795–805 (2003). · DOI
  80. Krull, C. E. Segmental organization of neural crest migration. Mech. Dev. 105, 37–45 (2001). · DOI
  81. Christiansen, J. H., Coles, E. G. & Wilkinson, D. G. Molecular control of neural crest formation, migration and differentiation. Curr. Opin. Cell Biol. 12, 719–724 (2000). · DOI
  82. Ellies, D. L., Church, V., Francis-West, P. & Lumsden, A. The WNT antagonist cSFRP2 modulates programmed cell death in the developing hindbrain. Development 127, 5285–5295 (2000). · DOI
  83. Yanfeng, W., Saint-Jeannet, J. P. & Klein, P. S. Wnt-frizzled signaling in the induction and differentiation of the neural crest. Bioessays 25, 317–325 (2003). · DOI
  84. Ikeya, M., Lee, S. M., Johnson, J. E., McMahon, A. P. & Takada, S. Wnt signalling required for expansion of neural crest and CNS progenitors. Nature 389, 966–970 (1997). · DOI
  85. Lee, S. K. & Pfaff, S. L. Transcriptional networks regulating neuronal identity in the developing spinal cord. Nature Neurosci. 4 (Suppl.), 1183–1191 (2001). · DOI
  86. Parr, B. A., Shea, M. J., Vassileva, G. & McMahon, A. P. Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development 119, 247–261 (1993). · DOI
  87. Dickinson, M. E., Krumlauf, R. & McMahon, A. P. Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system. Development 120, 1453–1471 (1994). · DOI
  88. Megason, S. G. & McMahon, A. P. A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development 129, 2087–2098 (2002). · DOI
  89. Muroyama, Y., Fujihara, M., Ikeya, M., Kondoh, H. & Takada, S. Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes Dev. 16, 548–553 (2002). · DOI
  90. Chizhikov, V. V. & Millen, K. J. Control of roof plate development and signaling by Lmx1b in the caudal vertebrate CNS. J. Neurosci. 24, 5694–5703 (2004). · DOI
  91. Zechner, D. et al. β-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Dev. Biol. 258, 406–418 (2003). · DOI
  92. Copp, A. J., Greene, N. D. & Murdoch, J. N. The genetic basis of mammalian neurulation. Nature Rev. Genet. 4, 784–793 (2003). · DOI
  93. Wallingford, J. B. & Harland, R. M. Neural tube closure requires Dishevelled-dependent convergent extension of the midline. Development 129, 5815–5825 (2002). · DOI
  94. Lijam, N. et al. Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1. Cell 90, 895–905 (1997). · DOI · Paper page
  95. Hamblet, N. S. et al. Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development 129, 5827–5838 (2002). · DOI
  96. Curtin, J. A. et al. Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr. Biol. 13, 1129–1133 (2003). · DOI
  97. Park, M. & Moon, R. T. The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos. Nature Cell Biol. 4, 20–25 (2002). · DOI · Paper page
  98. Nakagawa, S., Takada, S., Takada, R. & Takeichi, M. Identification of the laminar-inducing factor: Wnt-signal from the anterior rim induces correct laminar formation of the neural retina in vitro. Dev. Biol. 260, 414–425 (2003). · DOI
  99. Lucas, F. R. & Salinas, P. C. WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons. Dev. Biol. 192, 31–44 (1997). · DOI
  100. Hall, A. C., Lucas, F. R. & Salinas, P. C. Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling. Cell 100, 525–535 (2000). This study provides the first evidence of a role for WNT signalling in synaptogenesis. The addition of WNT7A to mossy fibre axons induces axonal remodelling and the clustering of synapsin I, a presynaptic protein. By constrast, analyses of the WNT7A mutant mouse reveal defects in axonal remodelling and synapsin I in the mossy fibre terminal. Consistent with a role for WNT in synaptogenesis, WNT7A mutant mice show delayed synaptic maturation in the cerebellum. So, WNT7A, expressed by cerebellar granule cells, functions as a retrograde signal to regulate the terminal arborization of axons and presynaptic differentiation in the mouse cerebellum. · DOI
  101. Krylova, O. et al. WNT-3, expressed by motoneurons, regulates terminal arborization of neurotrophin-3-responsive spinal sensory neurons. Neuron 35, 1043–1056 (2002). · DOI
  102. Fradkin, L. G. et al. The Drosophila Wnt5 protein mediates selective axon fasciculation in the embryonic central nervous system. Dev. Biol. 272, 362–375 (2004). · DOI
  103. Lyuksyutova, A. I. et al. Anterior-posterior guidance of commissural axons by Wnt-Frizzled signaling. Science 302, 1984–1988 (2003). This paper provides the first evidence that WNT signalling through FZ regulates axon guidance in vertebrates. WNT4, which is expressed in an A–P gradient in the floor plate, stimulates axon outgrowth and turning of commissural axons. This effect is mediated through FZ3, as mice lacking FZ3 show a defect in the normal anterior turning of commissural axons after they have crossed the midline. In contrast to the studies on DWNT5 (WNT5) in the fly, WNT4 acts as an attractive guidance molecule. · DOI
  104. Charron, F., Stein, E., Jeong, J., McMahon, A. P. & Tessier-Lavigne, M. The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell 113, 11–23 (2003). · DOI
  105. Wang, Y., Thekdi, N., Smallwood, P. M., Macke, J. P. & Nathans, J. Frizzled-3 is required for the development of major fiber tracts in the rostral CNS. J. Neurosci. 22, 8563–8573 (2002). · DOI
  106. Packard, M. et al. The Drosophila Wnt, wingless, provides an essential signal for pre- and postsynaptic differentiation. Cell 111, 319–330 (2002). · DOI
  107. Burden, S. J. Building the vertebrate neuromuscular synapse. J. Neurobiol. 53, 501–511 (2002). · DOI
  108. Sanes, J. R. & Lichtman, J. W. Induction, assembly, maturation and maintenance of a postsynaptic apparatus. Nature Rev. Neurosci. 2, 791–805 (2001). · DOI
  109. Luo, Z. G. et al. Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1. Neuron 35, 489–505 (2002). · DOI
  110. Wang, Y., Huso, D., Cahill, H., Ryugo, D. & Nathans, J. Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene. J. Neurosci. 21, 4761–4771 (2001). · DOI
  111. Lie, D. C., Song, H., Colamarino, S. A., Ming, G. -L. & Gage, F. H. Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu. Rev. Pharmacol. Toxicol. 44, 399–421 (2004). · DOI
  112. Gage, F. H. Mammalian neural stem cells. Science 287, 1433–1438 (2000). · DOI · Paper page
  113. Bazan, E. et al. In vitro and in vivo characterization of neural stem cells. Histol. Histopathol. 19, 1261–1275 (2004).
  114. Sancho, E., Batlle, E. & Clevers, H. Signaling pathways in intestinal development and cancer. Annu. Rev. Cell Dev. Biol. (2004). · DOI
  115. Alonso, L. & Fuchs, E. Stem cells in the skin: waste not, Wnt not. Genes Dev. 17, 1189–1200 (2003). · DOI
  116. Polesskaya, A., Seale, P. & Rudnicki, M. A. Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration. Cell 113, 841–852 (2003). · DOI
  117. Sato, N., Meijer, L., Skaltsounis, L., Greengard, P. & Brivanlou, A. H. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nature Med. 10, 55–63 (2004). · DOI
  118. Aubert, J., Dunstan, H., Chambers, I. & Smith, A. Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Nature Biotechnol. 20, 1240–1245 (2002). · DOI
  119. Haegele, L. et al. Wnt signalling inhibits neural differentiation of embryonic stem cells by controlling bone morphogenetic protein expression. Mol. Cell Neurosci. 24, 696–708 (2003). · DOI
  120. Murashov, A. K. et al. Directed differentiation of embryonic stem cells into dorsal interneurons. FASEB J. (2004). · DOI

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Metadata

Authors
Ciani, L., & Salinas, P. C.
Venue
Nature Reviews Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2005-04-15
Volume
6
Issue
5
Pages
351-362
ISSN
  • 1471-003X
  • 1471-0048
DOI
10.1038/nrn1665
Cited by
543
References
17
Language
en
Licence

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