The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Fgf/MAPK signalling is a crucial positional cue in somite boundary formation
Abstract
The temporal and spatial regulation of somitogenesis requires a molecular oscillator, the segmentation clock. Through Notch signalling, the oscillation in cells is coordinated and translated into a cyclic wave of expression of hairy-related and other genes. The wave sweeps caudorostrally through the presomitic mesoderm (PSM) and finally arrests at the future segmentation point in the anterior PSM. By experimental manipulation and analyses in zebrafish somitogenesis mutants, we have found a novel component involved in this process. We report that the level of Fgf/MAPK activation (highest in the posterior PSM) serves as a positional cue within the PSM that regulates progression of the cyclic wave and thereby governs the positions of somite boundary formation.
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Cites
Stages of embryonic development of the zebrafish
Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B., & Schilling, T. F. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030302 · Cited by 12,037
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444
Cobb, M. H., & Goldsmith, E. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.25.14843 · Cited by 1,719
Mohammadi, M., McMahon, G., Sun, L., Tang, C., Hirth, P., Yeh, B. K., Hubbard, S. R., & Schlessinger, J. (1997) · Science · doi:10.1126/science.276.5314.955 · Cited by 1,097
Palmeirim, I., Henrique, D., Ish-Horowicz, D., & Pourquié, O. (1997) · Cell · doi:10.1016/s0092-8674(00)80451-1 · Cited by 948
Cooke, J., & Zeeman, E. C. (1976) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(76)80131-2 · Cited by 784
fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.
Yamaguchi, T. P., Harpal, K., Henkemeyer, M., & Rossant, J. (1994) · Genes & Development · doi:10.1101/gad.8.24.3032 · Cited by 778
Reifers, F., Böhli, H., Walsh, E. C., Crossley, P. H., Stainier, D. Y. R., & Brand, M. (1998) · Development · doi:10.1242/dev.125.13.2381 · Cited by 686
Dubrulle, J., McGrew, M. J., & Pourquié, O. (2001) · Cell · doi:10.1016/s0092-8674(01)00437-8 · Cited by 667
Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo
Sun, X., Meyers, E. N., Lewandoski, M., & Martin, G. R. (1999) · Genes & Development · doi:10.1101/gad.13.14.1834 · Cited by 651
Notch signalling and the synchronization of the somite segmentation clock
Jiang, Y.-J., Aerne, B. L., Smithers, L., Haddon, C., Ish-Horowicz, D., & Lewis, J. (2000) · Nature · doi:10.1038/35044091 · Cited by 538
Self-citationMutations affecting somite formation and patterning in the zebrafish, Danio rerio
van Eeden, F. J. M., Granato, M., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.-P., Jiang, Y.-J., Robert, D. A. K., et al. (1996) · Development · doi:10.1242/dev.123.1.153 · Cited by 521
Self-citationFibroblast Growth Factors as Multifunctional Signaling Factors
Szebenyi, G., & Fallon, J. F. (1998) · International Review of Cytology · doi:10.1016/s0074-7696(08)60149-7 · Cited by 484
Jouve, C., Palmeirim, I., Henrique, D., Beckers, J., Gossler, A., Ish-Horowicz, D., & Pourquié, O. (2000) · Development · doi:10.1242/dev.127.7.1421 · Cited by 331
Holley, S. A., Geisler, R., & Nüsslein-Volhard, C. (2000) · Genes & Development · doi:10.1101/gad.14.13.1678 · Cited by 319
Saga, Y., Hata, N., Koseki, H., & Taketo, M. M. (1997) · Genes & Development · doi:10.1101/gad.11.14.1827 · Cited by 318
Nodal signaling patterns the organizer
Gritsman, K., Talbot, W. S., & Schier, A. F. (2000) · Development · doi:10.1242/dev.127.5.921 · Cited by 265
Yamamoto, A., Amacher, S. L., Kim, S., Geissert, D., Kimmel, C. B., & Robertis, E. M. D. (1998) · Development · doi:10.1242/dev.125.17.3389 · Cited by 219
Conservation of BMP signaling in zebrafish mesoderm patterning
Nikaido, M., Tada, M., Saji, T., & Ueno, N. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(96)00625-9 · Cited by 210
Sawada, A., Fritz, A., Jiang, Y.-J., Yamamoto, A., Yamasu, K., Kuroiwa, A., Saga, Y., & Takeda, H. (2000) · Development · doi:10.1242/dev.127.8.1691 · Cited by 203
Self-citationSpatial and Temporal Patterns of Cell Division during Early Xenopus Embryogenesis
Saka, Y., & Smith, J. C. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0101 · Cited by 172
Spatial response to fibroblast growth factor signalling inXenopusembryos
Christen, B., & Slack, J. M. W. (1999) · Development · doi:10.1242/dev.126.1.119 · Cited by 169
Shinya, M., Koshida, S., Sawada, A., Kuroiwa, A., & Takeda, H. (2001) · Development · doi:10.1242/dev.128.21.4153 · Cited by 157
Self-citationYamaguchi, T. P., Conlon, R. A., & Rossant, J. (1992) · Developmental Biology · doi:10.1016/0012-1606(92)90157-c · Cited by 152
Ras pathway signals are required for notch-mediated oncogenesis
Fitzgerald, K. J., Harrington, A. N., & Leder, P. (2000) · Oncogene · doi:10.1038/sj.onc.1203766 · Cited by 147
FGF receptor signalling is required to maintain neural progenitors during Hensen's node progression
Mathis, L., Kulesa, P. M., & Fraser, S. E. (2001) · Nature Cell Biology · doi:10.1038/35078535 · Cited by 140
Control and integration of cell signaling pathways during C. Elegans vulval development
Sundaram, M. V., & Han, M. (1996) · BioEssays · doi:10.1002/bies.950180609 · Cited by 68
Gotoh, Y. (1996) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(96)00009-1 · Cited by 12
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Clagett-Dame, M., & Knutson, D. (2011) · Nutrients · doi:10.3390/nu3040385 · Cited by 439
Dubrulle, J., & Pourquié, O. (2004) · Nature · doi:10.1038/nature02216 · Cited by 417
Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids
van den Brink, S. C., Alemany, A., van Batenburg, V., Moris, N., Blotenburg, M., Vivié, J., Baillie-Johnson, P., Nichols, J., Sonnen, K. F., Martinez Arias, A., et al. (2020) · Nature · doi:10.1038/s41586-020-2024-3 · Cited by 404
Spatial and temporal patterns of ERK signaling during mouse embryogenesis
Corson, L. B., Yamanaka, Y., Lai, K.-M. V., & Rossant, J. (2003) · Development · doi:10.1242/dev.00669 · Cited by 390
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Beenken, A., & Mohammadi, M. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-0887-1_1 · Cited by 93
Metadata
- Authors
- Sawada, A., Shinya, M., Jiang, Y.-J., Kawakami, A., Kuroiwa, A., & Takeda, H.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2001-12-01
- Volume
- 128
- Issue
- 23
- Pages
- 4873-4880
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2140800916
- Cited by
- 304
- References
- 28
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- closed
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