The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
RXRα ablation in skin keratinocytes results in alopecia and epidermal alterations
Abstract
RXRα is the most abundant of the three retinoid X receptors (RXRs) in the epidermis. In this study, we have used Cre-mediated recombination to selectively disrupt the mouse gene for RXRα in epidermal and hair follicle keratinocytes. We show that RXRα is apparently dispensable for prenatal epidermal development, while it is involved in postnatal skin maturation. After the first hair pelage, mutant mice develop a progressive alopecia, histologically characterised by the destruction of hair follicle architecture and the formation of utriculi and dermal cysts in adult mice. Our results demonstrate that RXRα plays a key role in anagen initiation during the hair follicle cycle. In addition, RXRα ablation results in epidermal interfollicular hyperplasia with keratinocyte hyperproliferation and aberrant terminal differentiation, accompanied by an inflammatory reaction of the skin. Our data not only provide genetic evidence that RXRα/VDR heterodimers play a major role in controlling hair cycling, but also suggest that additional signalling pathways mediated by RXRα heterodimerised with other nuclear receptors are involved in postnatal hair follicle growth, and homeostasis of proliferation/differentiation of epidermal keratinocytes and of the skin’s immune system.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Self-citationAdhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
A decade of molecular biology of retinoic acid receptors
Chambon, P. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801176 · Cited by 2,889
Self-citationMetzger, D., Clifford, J., Chiba, H., & Chambon, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6991 · Cited by 570
Self-citation
Cited by
Getting under the skin of epidermal morphogenesis
Fuchs, E., & Raghavan, S. (2002) · Nature Reviews Genetics · doi:10.1038/nrg758 · Cited by 753
Mark, M., Ghyselinck, N. B., & Chambon, P. (2006) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141156 · Cited by 593
Self-citationMultiple roles of phosphoinositide-specific phospholipase C isozymes
Suh, P.-G., Park, J.-I., Manzoli, L., Cocco, L., Peak, J. C., Katan, M., Fukami, K., Kataoka, T., Yun, S.-U., & Ryu, S.-H. (2008) · BMB Reports · doi:10.5483/bmbrep.2008.41.6.415 · Cited by 501
International Union of Pharmacology. LXIII. Retinoid X receptors
Germain, P., Chambon, P., Eichele, G., Evans, R. M., Lazar, M. A., Leid, M., De Lera, A. R., Lotan, R., Mangelsdorf, D. J., & Gronemeyer, H. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.7 · Cited by 496
Self-citationMichalik, L., Desvergne, B., Tan, N. S., Basu-Modak, S., Escher, P., Rieusset, J., Peters, J. M., Kaya, G., Gonzalez, F. J., Zakany, J., et al. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200011148 · Cited by 406
Self-citationA directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse
Schnütgen, F., Doerflinger, N., Calléja, C., Wendling, O., Chambon, P., & Ghyselinck, N. B. (2003) · Nature Biotechnology · doi:10.1038/nbt811 · Cited by 401
Self-citationRetinoid X receptors: common heterodimerization partners with distinct functions
Lefebvre, P., Benomar, Y., & Staels, B. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2010.06.009 · Cited by 309
At the Roots of a Never-Ending Cycle
Fuchs, E., Merrill, B. J., Jamora, C., & DasGupta, R. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00022-3 · Cited by 273
Campbell, L., Emmerson, E., Davies, F., Gilliver, S. C., Krust, A., Chambon, P., Ashcroft, G. S., & Hardman, M. J. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100500 · Cited by 175
Self-citationRezvani, H. R., Ali, N., Serrano-Sanchez, M., Dubus, P., Varon, C., Ged, C., Pain, C., Cario-André, M., Seneschal, J., Taïeb, A., et al. (2011) · Journal of Cell Science · doi:10.1242/jcs.082370 · Cited by 90
Hyter, S., Coleman, D. J., Ganguli‐Indra, G., Merrill, G. F., Ma, S., Yanagisawa, M., & Indra, A. K. (2013) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12063 · Cited by 61
Metadata
- Authors
- Li, M., Chiba, H., Warot, X., Messaddeq, N., Gérard, C., Chambon, P., & Metzger, D.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2001-03-01
- Volume
- 128
- Issue
- 5
- Pages
- 675-688
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2143817027
- Cited by
- 214
- References
- 4
- FWCI
- 18.26
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
