The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Generation of different fates from multipotent muscle stem cells
Abstract
Although neuronal and mesenchymal stem cells exhibit multipotentiality, this property has not previously been demonstrated for muscle stem cells. We now show that muscle satellite cells of adult mice are able to differentiate into osteoblasts, adipocytes and myotubes. Undifferentiated muscle progenitor cells derived from a single satellite cell co-expressed multiple determination genes including those for MyoD and Runx2, which are specific for myogenic and osteogenic differentiation, respectively. Determination genes not relevant to the induced differentiation pathway were specifically downregulated in these cells. Similar multipotent progenitor cells were isolated from adult human muscle. Based on these observations, we propose a ‘stock options’ model for the generation of different fates from multipotent stem cells.
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Cites
MyoD is required for myogenic stem cell function in adult skeletal muscle
Megeney, L. A., Kablar, B., Garrett, K., Anderson, J. E., & Rudnicki, M. A. (1996) · Genes & Development · doi:10.1101/gad.10.10.1173 · Cited by 724
Cited by
Molecular Signature of Quiescent Satellite Cells in Adult Skeletal Muscle
Fukada, S.-I., Uezumi, A., Ikemoto, M., Masuda, S., Segawa, M., Tanimura, N., Yamamoto, H., Miyagoe-Suzuki, Y., & Takeda, S. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0019 · Cited by 506
Intrinsic Changes and Extrinsic Influences of Myogenic Stem Cell Function During Aging
Brack, A. S., & Rando, T. A. (2007) · Stem Cell Reviews · doi:10.1007/s12015-007-9000-2 · Cited by 238
Ono, Y., Calhabeu, F., Morgan, J. E., Katagiri, T., Amthor, H., & Zammit, P. S. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.95 · Cited by 198
Alterations in the TGFβ signaling pathway in myogenic progenitors with age
Beggs, M. L., Nagarajan, R., Taylor‐Jones, J. M., Nolen, G., MacNicol, M., & Peterson, C. A. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00135.x · Cited by 74
Ma, C., Zhang, P., & Shen, Y. (2019) · Journal of Neurorestoratology · doi:10.26599/jnr.2019.9040024 · Cited by 19
Metadata
- Authors
- Wada, M. R., Inagawa-Ogashiwa, M., Shimizu, S., Yasumoto, S., & Hashimoto, N.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2002-06-15
- Volume
- 129
- Issue
- 12
- Pages
- 2987-2995
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2185288066
- Cited by
- 258
- References
- 1
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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