Progress in research into spinal cord injury repair: Tissue engineering scaffolds and cell transdifferentiation
Open accessAbstract
As with all tissues of the central nervous system, the low regeneration ability of spinal cord tissue after injury decreases the potential for repair and recovery. Initially, in spinal cord injuries (SCI), often the surgeon can only limit further damage by early surgical decompression. However, with the development of basic science, especially the development of genetic engineering, molecular biology, tissue engineering, and materials science, some promising progress has been made in promoting the repair of central nervous system injuries. For example, transplantation of neural stem cells (NSCs), olfactory ensheathing cells (OECs), and gene- mediated transdifferentiation to repair central nervous system injury. This paper summarizes the progress and prospects of SCI repair with tissue engineering scaffold and cell transdifferentiation from an extensive literatures.
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Due to environmental inhibitory factors in central nervous system, nerve axon regeneration ability is limited and often cannot get good therapeutic effect.
“Due to the existence of environmental inhibitory factors in the central nervous system, the ability of nerve axon regeneration is limited, and often cannot get a good therapeutic effect [176, 177].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [176]
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Application of PLCL as a biodegradable polymer in biomedical engineering
Zhao, Y., & Liu, H. (2026) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-026-07016-3 · Cited by 7 · see citing works
“Due to the existence of environmental inhibitory factors in the central nervous system, the ability of nerve axon regeneration is limited, and often cannot get a good therapeutic effect [176, 177].”
- Authors
- Ma, C., Zhang, P., & Shen, Y.
- Affiliations
- Second Affiliated Hospital of Soochow University (CN)
- Corresponding author
- Shen, Yixin
- Venue
- Journal of Neurorestoratology
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 7
- Issue
- 4
- Pages
- 196-206
- ISSN
- 2324-2426 (ISSN-L)
- OpenAlex
- W3005770793
- Cited by
- 19
- References
- 64
- Citations by year
- 2026: 2 · 2025: 4 · 2023: 2 · 2022: 3 · 2021: 7 · 2020: 1
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Neurorestoratology (publishedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- spinal cord injury, tissue engineering scaffolds, transdifferentiation, neural stem cell transplantation, olfactory ensheathing cells, central nervous system regeneration, spinal cord repair
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