Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland

Li, Gang, Robinson, Gertraud W., Lesche, Ralf, Martinez-Diaz, Hilda, Jiang, Zhaorong, Rozengurt, Nora, Wagner, Kay-Uwe, Wu, De-Chang +4 more·2002·Development
DOI 10.1242/dev.129.17.4159

Cited by (273)

Items 201–273 of 273

  1. Common Genomic Aberrations in Mouse and Human Breast Cancers with Concurrent P53 Deficiency and Activated PTEN-PI3K-AKT Pathway
    Jarrod D. Martinez, Qianxing Mo, Yixiang Xu, Li Qin, Yi Li, Jianming Xu · 2021 · International Journal of Biological Sciences
  2. Role of Protein Kinase B-Dependent Signaling in Lung Tumorigenesis
    Jonathan M. Kurie · 2004 · CHEST Journal
  3. The Use of Cre–loxP Technology and Inducible Systems to Generate Mouse Models of Cancer
    Chu‐Xia Deng · 2011 · Springer eBooks
  4. Mechanisms of Apoptosis Resistance In Breast Cancer
    Lily P H Yang · 2007 · Springer eBooks
  5. A recombinant protein TmSm(T34A) can inhibit proliferation and proapoptosis to breast cancer stem cells(BCSCs) by down-regulating the expression of Cyclin D1
    Xingyuan Ma, Yi Zhang, Yanyan Kang, Linfeng Li, Wenyun Zheng · 2016 · Biomedicine & Pharmacotherapy
  6. A review of pediatric macromastia etiology and indications for reduction mammaplasty
    Daniel Seicho Kikuchi, Danielle E. Mustin, Arian Ghanouni, Mark D. Walsh · 2022 · Journal of Plastic Reconstructive & Aesthetic Surgery
  7. Mammary-digital-nail (MDN) syndrome: a novel phenotype maps to human chromosome 22q12.3–13.1
    Mira Genzer-Nir, Morad Khayat, Leonid Kogan, Hector Isaac Cohen, Miriam Hershkowitz, Dan Geiger, Tzipora C. Falik Zaccai · 2010 · European Journal of Human Genetics
  8. Signaling Pathways Supporting Tumor Invasion in Head and Neck Squamous Cell Carcinoma
    Michal Kidacki Heather L · 2015 · Journal of Clinical & Experimental Pathology
  9. Dual recombinase action in the normal and neoplastic mammary gland epithelium
    Patrick D. Rädler, Kerry S. Vistisen, Aleata A. Triplett, Rayane Dennaoui, Yong Li, Hridaya Shrestha, Rosa‐Maria Ferraiuolo, Amalraj Thangasamy, Dieter Saur, Kay‐Uwe Wagner · 2021 · Scientific Reports
  10. Active Gα i/o Mutants Accelerate Breast Tumor Metastasis via the c-Src Pathway
    Cancan Lyu, Aarzoo K. Bhimani, William T. Draus, Ronald J. Weigel, Songhai Chen · 2023 · Molecular and Cellular Biology
  11. Tumor Suppressor Genes
    Yue Cheng · 2012 · InTech eBooks
  12. NEDD9 Overexpression Causes Hyperproliferation of Luminal Cells and Cooperates with HER2 Oncogene in Tumor Initiation: A Novel Prognostic Marker in Breast Cancer
    Marc L. Purazo, Ryan J. Ice, Rahul Shimpi, Mark James Hoenerhoff, Elena N. Pugacheva · 2023 · Cancers
  13. Mouse Models of Inherited Cancer Syndromes
    Sohail Jahid, Steven M. Lipkin · 2010 · Hematology/Oncology Clinics of North America
  14. Mammary Gland Cancer
    Dalit Barkan, Cristina Montagna, Thomas Ried, Jeffrey E. Green · 2004
  15. Role of ERα and Aromatase in Juvenile Gigantomastia
    Richard J. Santen, Gülay Karagüzel, Murat Livaoğlu, Wei Yue, J. Mark Cline, Aakrosh Ratan, Hironobu Sasano · 2024 · The Journal of Clinical Endocrinology & Metabolism
  16. Aberrant RET expression affects normal mammary gland post-lactation transition, enhancing cancer potential
    Sabrina A. Vallone, Martín E. García Solá, Carolina Schere‐Levy, Roberto Pablo Meiss, Gladys N. Hermida, Lewis A. Chodosh, Edith C. Kordon, Nancy E. Hynes, Albana Gattelli · 2022 · Disease Models & Mechanisms
  17. The gene dosage of class Ia PI3K dictates the development of PTEN hamartoma tumor syndrome
    Qi Wang, Ellen Weisberg, jing zhao · 2013 · Cell Cycle
  18. Virginal breast hypertrophy in a 14‐year‐old girl: A case report
    Biraj Pokhrel, Sandesh Gautam, Samit Sharma, Nishan Babu Pokhrel, Naveen Chandra Bhatta, Sangam Rayamajhi, Jayan Man Shrestha · 2020 · Clinical Case Reports
  19. Morphologic Manifestations of Gene-Specific Molecular Alterations (“Genetic Addictions”) in Mouse Models of Disease
    Suzana S. Couto, Brad N. Bolon, Robert D. Cardiff · 2011 · Veterinary Pathology
  20. Injectable Biomimetic Hydrogel Constructs for Cell-Based Menopausal Hormone Therapy with Reduced Breast Cancer Potential
    Chungmo Yang, Heeseon Yang, Hyerim Kim, Nanum Chung, Jungwoo Shin, Hyewon Min, Kangwon Lee, Jung Ryeol Lee · 2024 · Biomaterials Research
  21. Effects of indomethacin on expression of PTEN tumour suppressor in human cancers
    Imran Haruna Abdulkareem, Maria Blair · 2013 · Nigerian Medical Journal
  22. Small SNPs, Big Effects: A Review of Single Nucleotide Variations and Polymorphisms in Key Genes Associated With Autism Spectrum Disorder
    Sriharikrishnaa Srinath, Akanksha A. Kalal, Preethika Anand, Satyajit Mohapatra, Prabahan Chakraborty · 2025 · International Journal of Developmental Neuroscience
  23. Elevated expression of wildtype RhoC promotes ErbB2- and Pik3ca-induced mammary tumor formation
    Nandini Raghuram, Emirhan Temel, Toshihiro Kawamata, Katelyn J. Kozma, Amanda J. Loch, Wei Wang, Jessica R. Adams, William J. Muller, Sean E. Egan · 2024 · Breast Cancer Research
  24. Non-redundant roles of the phosphoinositide phosphatases PTEN and PIPP in PI3K/AKT signaling in breast cancer
    Lisa M. Ooms, Daniel T. Ferguson, Samuel J. Rodgers, Karmanpreet K. Sukhija, Emily I. Jones, Mariah P. Csolle, Hon Yan Kelvin Yip, Roger J. Daly, Tony Tiganis, Catriona McLean et al. · 2025 · Communications Biology
  25. Virginal Breast Hypertrophy: A Case Report
    Sarah A Soliman, Mohammad A Algatheradi, Thuraya A Aljahwashi, Taef H Alhussan, Riyadh Alqahtani, Nahid I Ali · 2023 · Cureus
  26. Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer
    Warapen Treekitkarnmongkol, Vandna Shah, Kazuharu Kai, Hiroshi G. Katayama, Justin Wong, Farah Ladha, Tristian Nguyen, Brian A. Menegaz, Wei Lü, Fei Yang et al. · 2024 · British Journal of Cancer
  27. Isogenic human mammary epithelial cell lines: novel tools for target identification and validation
    Ulrike Ulbricht, Anette Sommer, Georg Beckmann, Manuel Lutzenberger, Henrik Seidel, Bertolt Kreft, Luisella Toschi · 2013 · Breast Cancer Research and Treatment
  28. The Protective Effect of Cu/Zn-SOD Against Oxidative Stress After PTEN Deletion
    Changhong Yu, Pei-lin Wang, Sheng Li, Xiuhai Wang, Zhenlei Yu, Zhenhua Wang · 2011 · Cancer Investigation
  29. Combined Haploinsufficiency and Genetic Control of the G2/M Checkpoint in Irradiated Cells
    Erik F. Young, Lubomir B. Smilenov, Howard B. Lieberman, Eric J. Hall · 2012 · Radiation Research
  30. PCR-SSCP-DNA Sequencing Method in DetectingPTENGene Mutation and its Significance in Human Breast Cancer in Turkish Populations
    Hasibe Cıngıllı Vural · 2012 · Biotechnology & Biotechnological Equipment
  31. Mammary adipocyte plasticity and epithelial crosstalk: roles in development, remodeling, and disease
    Peitong Chen, Yunjun Liao, Junrong Cai · 2026 · Reviews in Endocrine and Metabolic Disorders
  32. Susceptibility of Epithelium to PTEN-Deficient Tumorigenesis
    Chun‐Ming Chen, Tsai-Ling Lu, Fang‐Yi Su, Li‐Ru You · 2012 · InTech eBooks
  33. Soy Foods: Towards the Development of Novel Therapeutics for Breast Cancer
    Rosalia C. M. Simmen, Omar M. Rahal, Maria Theresa E. Montales, John Mark P. Pabona, Melissa E. Heard, Ahmed Al‐Dwairi, Adam R. Brown, Frank A. Simmen · 2013 · Evidence-based anticancer complementary and alternative medicine
  34. Our experience in surgical treatment of bilateral pseudoangiomatous stromal hyperplasia in children with gigantomastia
    О.И. Старцева, A. V. Bystrov, Tatiana A. Gassan, Iu V Isaev, S.I. Ivanov, D.I. Kiseleva · 2021 · Plastic Surgery and Aesthetic Medicine
  35. Reactivation of Multipotency in the Mammary Gland – a Ripple in the Pond and a Turn of the Tide
    C. Hager, Charly Jehanno, Mohamed Bentires‐Alj · 2025 · Journal of Mammary Gland Biology and Neoplasia
  36. Mouse Models of Breast Cancer: Deceptions that Reveal the Truth
    Joana Pinto Couto, Mohamed Bentires‐Alj · 2017 · Springer eBooks
  37. Molecular regulation of breast cancer susceptibility by dietary factors
    Ying Su · ProQuest Demo Repository
  38. Identification of novel protein binding partners for the tumor suppressor DLC1
    Johanna Heering · 2009 · OPUS Publication Server of the University of Stuttgart (University of Stuttgart)
  39. Exploring molecular mechanisms controlling skin homeostasis and hair growth : microRNAs in hair-cycle-dependent gene regulation, hair growth and associated tissue remodelling
    Mohammed I. Ahmed · 2010 · OpenGrey (Institut de l'Information Scientifique et Technique)
  40. The effects of Phosphatase and Tensin Homolog (PTEN) overexpression on longevity of cultured Human Umbilical Vein Endothelial Cells (HUVEC)
    Izak Tait · 2014 · Tuwhera (Auckland University of Technology)
  41. Targeting the Phosphoinositide‐3‐kinase/Akt/Mammalian Target of Rapamycin Pathway
    Courtney A. Granville, Regan Michelle Memmott, Joell J. Gills, Phillip A. Dennis · 2006 · Wiley eBooks
  42. ANALYSIS OF THE ROLE OF TWO AUTOPHAGY PATHWAY RELATED GENES, BECN1 AND TSC1, IN MURINE MAMMARY GLAND DEVELOPMENT AND DIFFERENTIATION
    Amber N. Hale · 2014 · UKnowledge (University of Kentucky)
  43. P-REX2 PH Domain Inhibition of PTEN Regulates Transformation, Insulin Signaling, and Glucose Homeostasis
    Cindy Hodakoski · 2012
  44. Investigating the roles of two key negative regulators of the PI3K pathway in T cell-mediated autoimmunity
    Trina Johnson · 2007
  45. Konditionale Inaktivierung von Pten in einem neuen Mausmodell fur tomaculose Neuropathien
    Jan Hendrik Oltrogge · 2017
  46. The Regulation of PREX2 by Phosphorylation
    Douglas Barrows · 2015
  47. Ectopic Notch1 Activation Alters Mammary Cell Fate During Puberty and Promotes the Development of Lactating Adenomas during Pregnancy
    Aaron Kucharczuk · 2010 · TSpace (University of Toronto)
  48. Investigation of Ring Finger Protein 8 in Mammalian Physiology and Pathogenesis
    Li, Li · 2015 · TSpace (University of Toronto)
  49. Genetic Analysis of Gata3 and Runx1 in Mammary Tumor Formation
    Nayasta Ademmana Kusdaya · 2015 · TSpace (University of Toronto)
  50. Foxo Transcription Factors Control Spermatogonial Stem Cell Self-Renewal and the Initiation of Spermatogenesis
    Meredith J. Goertz · 2013
  51. The role of mTORC2 in mammary morphogenesis and HER2-mediated tumorigenesis
    Meghan M. Morrison · 2015
  52. Cooperating Oncogenic Alterations in Aggressive Pten-Deficient Breast Cancer
    Sharon Wang · 2017 · TSpace (University of Toronto)
  53. Genotype-phenotype correlations in mouse musculoskeletal development and disease
    Alice Fiona Ford-Hutchinson · 2006 · Libraries and Cultural Resources (University of Calgary)
  54. Genetically Engineered Mouse Models for Studying Radiation Biology and Radiosensitizers
    Warren Floyd, Hsuan-Cheng Kuo, Jonathon E. Himes, Rutulkumar Patel, David G. Kirsch · 2020 · Cancer drug discovery and develogment/Cancer drug discovery and development
  55. Virginal breast hypertrophy: A case report
    Biraj Pokhrel, Sandesh Gautam, Naveen Chandra Bhatta, Nishan Babu Pokhrel, Samit Sharma, Sangam Rayamajhi, Jayan Man Shrestha · 2020
  56. Impaired Pulmonary Host Defense Against Pseudomonas aeruginosa Following Bone Marrow Transplantation.
    Leah L. N. Hubbard · 2011 · Deep Blue (University of Michigan)
  57. Breast Physiology
    Rena B. Kass, Anne T. Mancino, Arlan L. Rosenbloom, V. Suzanne Klimberg, Kirby I. Bland · 2009 · Elsevier eBooks
  58. Juvenile gigantomastia: Subcutaneous mastectomy with primary reconstruction
    Jasmina Ivić, Marija Dunjic, Isidora Tamindzic, Zivorad Kocevski, Boban Djordjevic, Boško Milev · 2022 · Vojnosanitetski pregled
  59. Pten is a disconnecting node in the molecular landscape of the proliferation/quiescence decision during mammary gland acinogenesis
    Rebeka Tomasin, Ana Maria Rodrigues, Antonio Carlos Manucci, Alexandre Bruni‐Cardoso · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  60. Data from PTEN Loss Promotes rasHa-Mediated Papillomatogenesis via Dual Up-Regulation of AKT Activity and Cell Cycle Deregulation but Malignant Conversion Proceeds via PTEN-Associated Pathways
    Denggao Yao, Claire L. Alexander, Jean A. Quinn, Michael J. Porter, Hong Wu, David A. Greenhalgh · 2023
  61. Data from PTEN Loss Promotes rasHa-Mediated Papillomatogenesis via Dual Up-Regulation of AKT Activity and Cell Cycle Deregulation but Malignant Conversion Proceeds via PTEN-Associated Pathways
    Denggao Yao, Claire L. Alexander, Jean A. Quinn, Michael Porter, Hong Wu, David A. Greenhalgh · 2023
  62. Data from Pten Loss Causes Hypertrophy and Increased Proliferation of Astrocytes In vivo
    Melissa M. Fraser, Xiaoyan Zhu, Chang-Hyuk Kwon, Erik J. Uhlmann, David H. Gutmann, Suzanne J. Baker · 2023
  63. The role of NEDD9 in HER2-driven breast cancer.
    Marc L. Purazo · 2023
  64. Breast Lesions in Children and Adolescents
    2023 · American Registry of PathologyArlington, Virginia eBooks
  65. Mammary Gland
    Suzanne E. Fenton, Schantel Hayes Bouknight · 2025 · Elsevier eBooks
  66. Clinical and surgical outcomes of virginal breast hypertrophy (VBH) in adolescent females: a systematic review of case reports
    Erum Siddiqui, Maliha Khalid, Muhammad Saad Khan, Umaimah Naeem, Aminath Waafira · 2025 · Annals of Medicine and Surgery
  67. Development of a more penetrating HER2-positive Breast Cancer Tumor Model and Testing Efficacy of SHP2 Targeting with an Active-Site Inhibitor
    Yehenew M. Agazie, James Mersch, Dhanaji M. Lade, Paul R. Lockman · 2025 · Research Square
  68. Additional file 1 of Elevated expression of wildtype RhoC promotes ErbB2- and Pik3ca-induced mammary tumor formation
    Nandini Raghuram, Temel, E. Idil, Toshihiro Kawamata, Kozma, Katelyn J., Amanda J. Loch, Wei Wang, Jessica R. Adams, William J. Muller, Sean E. Egan · 2024 · Figshare
  69. Additional file 1 of The relationship between pepsinogen C and gastric carcinogenesis: a transgene and population study
    E., Ying, Yu, Qian, Sun, Tao, Xue, Hang, Zhao, Xue-rong, Zheng, Hua-chuan · 2023 · Figshare
  70. Additional file 2 of The relationship between pepsinogen C and gastric carcinogenesis: a transgene and population study
    E., Ying, Yu, Qian, Sun, Tao, Xue, Hang, Zhao, Xue-rong, Zheng, Hua-chuan · 2023 · Figshare
  71. Plasticizers induce central precocious puberty via dysregulation of EGFR/MYC/PTEN/mTOR-mediated HPG axis activation
    Lixue Ouyang, Yu Yan, Haodongfang Zhang, Fan Yang · 2026 · Ecotoxicology and Environmental Safety
  72. Studies of phosphatidylinositol 3 kinase (PI3K) signaling pathway in mammalian ovarian follicle activation and development
    Rajareddy Singareddy · 2007 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
  73. Molecular studies of intra-oocyte phosphatidylinositol 3 kinase (PI3K) signaling pathway in controlling female fertility
    Dubbaka Venu, Pradeep Reddy · 2009