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Genetic alterations of PTEN in human melanoma

Aguissa-Touré, A.-H., & Li, G. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0878-0 · Cited by 161 · see citing works

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

Backman, S. A., Ghazarian, D., So, K., Sanchez, O. H., Wagner, K., Hennighausen, L. G., Suzuki, A., Tsao, M., Chapman, W. B., Stambolic, V., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308217100 · Cited by 159 · see citing works

Neoadjuvant Treatment for Triple Negative Breast Cancer: Recent Progresses and Challenges

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Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status

Jiang, Z., Deng, T., Jones, R. A., Li, H., Herschkowitz, J. I., Liu, J. C., Weigman, V., Tsao, M., Lane, T. F., Perou, C. M., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41490 · Cited by 148 · see citing works

PTEN in DNA damage repair

Ming, M., & He, Y. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.01.003 · Cited by 146 · see citing works

PTEN, Stem Cells, and Cancer Stem Cells

Hill, R., & Wu, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r800071200 · Cited by 145 · see citing works

Deciphering the Role of PI3K/Akt/mTOR Pathway in Breast Cancer Biology and Pathogenesis

McAuliffe, P. F., Meric‐Bernstam, F., Mills, G. B., & Gonzalez-Angulo, A. M. (2010) · Clinical Breast Cancer · doi:10.3816/cbc.2010.s.013 · Cited by 136 · see citing works

Mislocalization of the Cell Polarity Protein Scribble Promotes Mammary Tumorigenesis and Is Associated with Basal Breast Cancer

Feigin, M. E., Akshinthala, S. D., Araki, K., Rosenberg, A. Z., Muthuswamy, L. B., Martin, B., Lehmann, B. D., Berman, H. K., Pietenpol, J. A., Cardiff, R. D., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3415 · Cited by 135 · see citing works

The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis

Ooms, L. M., Binge, L. C., Davies, E. M., Rahman, P., Conway, J. R. W., Gurung, R., Ferguson, D. T., Papa, A., Fedele, C. G., Vieusseux, J. L., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.07.003 · Cited by 127 · see citing works

Mammary Involution and Breast Cancer Risk: Transgenic Models and Clinical Studies

Radisky, D. C., & Hartmann, L. C. (2009) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-009-9123-y · Cited by 127 · see citing works

Luminal Expression of PIK3CA Mutant H1047R in the Mammary Gland Induces Heterogeneous Tumors

Meyer, D. S., Brinkhaus, H., Müller, U., Müller, M., Cardiff, R. D., & Bentires‐Alj, M. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3827 · Cited by 125 · see citing works

Loss of caveolin‐1 in prostate cancer stroma correlates with reduced relapse‐free survival and is functionally relevant to tumour progression

Ayala, G., Morello, M., Frolov, A., You, S., Li, R., Rosati, F., Bartolucci, G., Danza, G., Adam, R. M., Thompson, T. C., et al. (2013) · The Journal of Pathology · doi:10.1002/path.4217 · Cited by 121 · see citing works

Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions

Subramanian, K. K., Jia, Y., Zhu, D., Simms, B. T., Jo, H., Hattori, H., You, J., Mizgerd, J. P., & Luo, H. R. (2007) · Blood · doi:10.1182/blood-2006-10-055319 · Cited by 118 · see citing works

Physiological Functions of Pten in Mouse Tissues.

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miR-21 is targeted by omega-3 polyunsaturated fatty acid to regulate breast tumor CSF-1 expression

Mandal, C. C., Ghosh-Choudhury, T., Dey, N., Choudhury, G. G., & Ghosh‐Choudhury, N. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs198 · Cited by 113 · see citing works

miR-29b regulates migration of human breast cancer cells

Wang, C., Bian, Z., Wei, D., & Zhang, J. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0755-z · Cited by 112 · see citing works

Correction: Lactation Defect with Impaired Secretory Activation in AEBP1-Null Mice

Zhang, L., Reidy, S. P., Bogachev, O., Hall, B. K., & Majdalawieh, H.-S. A. (2011) · PLoS ONE · doi:10.1371/annotation/4056d03c-20ed-4eca-9568-3e9400e2312e · Cited by 111 · see citing works

Combined deletion of Pten and p53 in mammary epithelium accelerates triple‐negative breast cancer with dependency on eEF2K

Liu, J. C., Voisin, V., Wang, S., Wang, D., Jones, R. A., Datti, A., Uehling, D., Al‐awar, R., Egan, S. E., Bader, G. D., et al. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201404402 · Cited by 110 · see citing works

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

Marsh, V. L., Winton, D. J., Williams, G. T., Dubois, N. C., Trumpp, A., Sansom, O. J., & Clarke, A. R. (2008) · Nature Genetics · doi:10.1038/ng.256 · Cited by 108 · see citing works

PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization

Yue, Q., Groszer, M., Gil, J. S., Berk, A. J., Messing, A., Wu, H., & Liu, X. (2005) · Development · doi:10.1242/dev.01891 · Cited by 107 · see citing works

The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey

Knobbe-Thomsen, C. B., Lapin, V., Suzuki, A., & Mak, T. W. (2008) · Oncogene · doi:10.1038/onc.2008.238 · Cited by 107 · see citing works

Inactivation of Pten in Osteo-Chondroprogenitor Cells Leads to Epiphyseal Growth Plate Abnormalities and Skeletal Overgrowth

Ford-Hutchinson, A. F., Ali, Z., Lines, S. E., Hallgrímsson, B., Boyd, S. K., & Jirik, F. R. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070420 · Cited by 108 · see citing works

Apoptosis regulation in the mammary gland

Green, K. A., & Streuli, C. H. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-3366-y · Cited by 105 · see citing works

Fish oil targets PTEN to regulate NFκB for downregulation of anti-apoptotic genes in breast tumor growth

Ghosh-Choudhury, T., Mandal, C. C., Woodruff, K. A., Clair, P. S., Fernandes, G., Choudhury, G. G., & Ghosh‐Choudhury, N. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-0227-7 · Cited by 100 · see citing works

Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts

Wickenden, J. A., & Watson, C. J. (2010) · Breast Cancer Research · doi:10.1186/bcr2558 · Cited by 97 · see citing works

The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN

Dave, B., Eason, R. R., Till, S. R., Geng, Y., Velarde, M. C., Badger, T. M., & Simmen, R. C. M. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi131 · Cited by 96 · see citing works

Portrait of PTEN: Messages from mutant mice

Suzuki, A., Nakano, T., Mak, T. W., & Sasaki, T. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2007.00670.x · Cited by 91 · see citing works

Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death

Zhu, D., Hattori, H., Jo, H., Jia, Y., Subramanian, K. K., Loison, F., You, J., Le, Y., Honczarenko, M., Silberstein, L. E., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605722103 · Cited by 86 · see citing works

Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors

Su, Y., Simmen, F. A., Xiao, R., & Simmen, R. C. M. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00023.2007 · Cited by 82 · see citing works

Conditional activation of Pik3caH1047R in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations

Yuan, W., Stawiski, E. W., Janakiraman, V., Chan, E., Durinck, S., Edgar, K. A., Kljavin, N. M., Rivers, C. S., Gnad, F., Roose‐Girma, M., et al. (2012) · Oncogene · doi:10.1038/onc.2012.53 · Cited by 77 · see citing works

Evaluation of cell-free tumour DNA and RNA in patients with breast cancer and benign breast disease

Schwarzenbach, H., Müller, V., Milde‐Langosch, K., Steinbach, B., & Pantel, K. (2011) · Molecular BioSystems · doi:10.1039/c1mb05197k · Cited by 75 · see citing works

PTEN Deficiency in a Luminal ErbB-2 Mouse Model Results in Dramatic Acceleration of Mammary Tumorigenesis and Metastasis

Schade, B., Rao, T., Dourdin, N., Lesurf, R., Hallett, M. T., Cardiff, R. D., & Muller, W. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.018937 · Cited by 75 · see citing works

Interaction of E-cadherin and PTEN Regulates Morphogenesis and Growth Arrest in Human Mammary Epithelial Cells

Fournier, M. V., Fata, J. E., Martin, K. J., Yaswen, P., & Bissell, M. J. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-1694 · Cited by 75 · see citing works

UVB-induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes

Ming, M. E., Han, W., Maddox, J., Soltani, K., Shea, C. R., Freeman, D. M., & He, Y. (2009) · Oncogene · doi:10.1038/onc.2009.357 · Cited by 74 · see citing works

Insulin-like Growth Factor-II Regulates PTEN Expression in the Mammary Gland

Moorehead, R. A., Hojilla, C. V., de Belle, I., Wood, G. A., Fata, J. E., Adamson, E. D., Watson, K. L. M., Edwards, D. R., & Khokha, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306894200 · Cited by 70 · see citing works

Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway

Kudo, Y., Tanaka, Y., Tateishi, K., Yamamoto, K., Yamamoto, S., Mohri, D., Isomura, Y., Seto, M., Nakagawa, H., Asaoka, Y., et al. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.03.025 · Cited by 69 · see citing works

High-Resolution Mapping of DNA Breakpoints to Define True Recurrences Among Ipsilateral Breast Cancers

Bollet, M. A., Servant, N., Neuvial, P., Decraene, C., Lebigot, I., Meyniel, J.-P., Rycke, Y. D., Savignoni, A., Rigaill, G. J., Hupé, P., et al. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm266 · Cited by 68 · see citing works

Microarray Analysis of the Involution Switch

Clarkson, R. W. E., & Watson, C. J. (2003) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/b:jomg.0000010031.53310.92 · Cited by 68 · see citing works

Distinct roles of the three Akt isoforms in lactogenic differentiation and involution

Maroulakou, I. G., Oemler, W., Naber, S. P., Klebba, I., Kuperwasser, C., & Tsichlis, P. N. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21518 · Cited by 66 · see citing works

Stat5 Regulates the Phosphatidylinositol 3-Kinase/Akt1 Pathway during Mammary Gland Development and Tumorigenesis

Schmidt, J. W., Wehde, B. L., Sakamoto, K., Triplett, A. A., Anderson, S. M., Tsichlis, P. N., Leone, G. W., & Wagner, K. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01220-13 · Cited by 64 · see citing works

Pten Deficiency Activates Distinct Downstream Signaling Pathways in a Tissue-Specific Manner

Yoo, L. I., Liu, D. W., Vu, S. L., Bronson, R. T., Wu, H., & Yuan, J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1986 · Cited by 64 · see citing works

In vitro activity of the mTOR inhibitor everolimus, in a large panel of breast cancer cell lines and analysis for predictors of response

Hurvitz, S. A., Kalous, O., Conklin, D. F., Desai, A. J., Dering, J., Anderson, L. A., O’Brien, N. A., Kolarova, T. R., Finn, R. S., Linnartz, R., et al. (2015) · Breast Cancer Research and Treatment · doi:10.1007/s10549-015-3282-x · Cited by 64 · see citing works

PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation

Rahal, O. M., & Simmen, F. A. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq123 · Cited by 64 · see citing works

Taming the PI3K team to hold inflammation and cancer at bay

Hirsch, E., Ciraolo, E., Ghigo, A., & Costa, C. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.02.004 · Cited by 63 · see citing works

PTEN: New Insights into Its Regulation and Function in Skin Cancer

Ming, M., & He, Y. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.79 · Cited by 62 · see citing works

Conditional Deletion of Shp2 in the Mammary Gland Leads to Impaired Lobulo-alveolar Outgrowth and Attenuated Stat5 Activation

Ke, Y., Lesperance, J., Zhang, E. E., Bard-Chapeau, E. A., Oshima, R. G., Muller, W. J., & Feng, G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607325200 · Cited by 61 · see citing works

PTEN in Hereditary and Sporadic CancerPreprint

Ngeow, J. Y. Y., & Eng, C. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036087 · Cited by 61 · see citing works

PTEN and Other PtdIns(3,4,5)P3 Lipid Phosphatases in Breast Cancer

Csolle, M. P., Ooms, L. M., Papa, A., & Mitchell, C. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239189 · Cited by 60 · see citing works

Atbf1 Regulates Pubertal Mammary Gland Development Likely by Inhibiting the Pro-Proliferative Function of Estrogen-ER Signaling

Li, M., Fu, X., Ma, G., Sun, X., Dong, X., Nagy, T., Xing, C., Li, J., & Dong, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051283 · Cited by 60 · see citing works

Breast Reduction in Adolescents: Indication, Timing, and a Review of the Literature

Xue, A. S., Wolfswinkel, E. M., Weathers, W. M., Chike-Obi, C. J., & Heller, L. (2013) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2013.03.005 · Cited by 60 · see citing works

Hereditary Genes and SNPs Associated with Breast Cancer

Mahdi, K. M., Nassiri, M., & Nasiri, K. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.6.3403 · Cited by 58 · see citing works

Hyperplastic Breast Anomalies in the Female Adolescent Breast

Wolfswinkel, E. M., Lemaine, V., Weathers, W. M., Chike-Obi, C. J., Xue, A. S., & Heller, L. (2013) · Seminars in Plastic Surgery · doi:10.1055/s-0033-1347167 · Cited by 58 · see citing works

PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma

Boelens, M. C., Nethe, M., Klarenbeek, S., de Ruiter, J. R., Schut, E., Bonzanni, N., Zeeman, A. L., Wientjens, E., van der Burg, E., Wessels, L. F. A., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.059 · Cited by 58 · see citing works

Regulation of constitutive expression of mouse PTEN by the 5′-untranslated region

Han, B., Dong, Z., Liu, Y., Chen, Q., Hashimoto, K., & Zhang, J. (2003) · Oncogene · doi:10.1038/sj.onc.1206783 · Cited by 58 · see citing works

Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression

Rangel, R., Lee, S.-C., Ban, K. H.-K., Guzman‐Rojas, L., Mann, M. B., Newberg, J. Y., Kodama, T., McNoe, L. A., Selvanesan, L., Ward, J. M., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613859113 · Cited by 58 · see citing works

Mutation of thyroid hormone receptor-β in mice predisposes to the development of mammary tumors

Guigon, C. J., Kim, D. W., Willingham, M. C., & Cheng, S.-Y. (2011) · Oncogene · doi:10.1038/onc.2011.50 · Cited by 56 · see citing works

The two faces of Janus kinases and their respective STATs in mammary gland development and cancer

Wagner, K., & Schmidt, J. W. (2011) · Journal of Carcinogenesis · doi:10.4103/1477-3163.90677 · Cited by 55 · see citing works

PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium

Dupont, J., Renou, J., Shani, M., Hennighausen, L. G., & LeRoith, D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213829 · Cited by 79 · see citing works

PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland

Shore, A. N., Chang, C.-H., Kwon, O.-J., Weston, M. C., Zhang, M., Xin, L., & Rosen, J. M. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2015.10.023 · Cited by 15 · see citing works

Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice

Li, Y., Podsypanina, K., Liu, X., Crane, A., Tan, L. K., Parsons, R. E., & VARMUS, H. E. (2001) · BMC Molecular Biology · doi:10.1186/1471-2199-2-2 · Cited by 82 · see citing works

PTEN deficiency: a role in mammary carcinogenesis

Petrocelli, T., & Slingerland, J. M. (2001) · Breast Cancer Research · doi:10.1186/bcr322 · Cited by 50 · see citing works

BMC Research Molecular articleBiology (2001) 2:2 Deficiency of Pten accelerates mammary oncogenesis in MMTV- Wnt-1 transgenic mice

Li, Y., Podsypanina, K., Liu, X., Crane, A., Tan, L. K., Parsons, R., & Varmus, H. E. (2000)