The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Morphogen rules: design principles of gradient-mediated embryo patterning
Open accessAbstract
The Drosophila blastoderm and the vertebrate neural tube are archetypal examples of morphogen-patterned tissues that create precise spatial patterns of different cell types. In both tissues, pattern formation is dependent on molecular gradients that emanate from opposite poles. Despite distinct evolutionary origins and differences in time scales, cell biology and molecular players, both tissues exhibit striking similarities in the regulatory systems that establish gene expression patterns that foreshadow the arrangement of cell types. First, signaling gradients establish initial conditions that polarize the tissue, but there is no strict correspondence between specific morphogen thresholds and boundary positions. Second, gradients initiate transcriptional networks that integrate broadly distributed activators and localized repressors to generate patterns of gene expression. Third, the correct positioning of boundaries depends on the temporal and spatial dynamics of the transcriptional networks. These similarities reveal design principles that are likely to be broadly applicable to morphogen-patterned tissues.
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Delile, J., Rayon, T., Melchionda, M., Edwards, A., Briscoe, J., & Sagner, A. (2019) · Development · doi:10.1242/dev.173807 · Cited by 356
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Optimal decoding of cellular identities in a genetic network
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Tissue Biology: In Search of a New Paradigm
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Metadata
- Authors
- Briscoe, J., & Small, S.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2015-12-01
- Volume
- 142
- Issue
- 23
- Pages
- 3996-4009
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2207941023
- Cited by
- 490
- References
- 14
- FWCI
- 13.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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