Shadow enhancers as a source of evolutionary novelty

Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the <i>Drosophila</i> embryo

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The Evolution of Gene Regulation Underlies a Morphological Difference between Two Drosophila Sister Species

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A functional screen for sonic hedgehog regulatory elements across a 1 Mb interval identifies long-range ventral forebrain enhancers

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Redundant and Unique Roles of Two Enhancer Elements in the TCRγ Locus in Gene Regulation and γδ T Cell Development

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Comprehensive identification of <i>Drosophila</i> dorsal–ventral patterning genes using a whole-genome tiling array

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Transcription factors: from enhancer binding to developmental control

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Cis-regulatory elements: Molecular mechanisms and evolutionary processes underlying divergence

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Control of the Embryonic Stem Cell State

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Long-range enhancer–promoter contacts in gene expression control

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The selection and function of cell type-specific enhancers

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Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution

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Enhancer redundancy provides phenotypic robustness in mammalian development

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A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens

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Morphogen Gradients: From Generation to Interpretation

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Phenotypic robustness conferred by apparently redundant transcriptional enhancers

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Morphogen rules: design principles of gradient-mediated embryo patterning

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A Regulatory Archipelago Controls Hox Genes Transcription in Digits

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Convergence of Developmental and Oncogenic Signaling Pathways at Transcriptional Super-Enhancers

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The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements

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Functional and topological characteristics of mammalian regulatory domains

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Transcriptional Enhancers in Animal Development and Evolution

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Genome-scale functional characterization of Drosophila developmental enhancers in vivo

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Towards a comprehensive catalogue of validated and target-linked human enhancers

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Shadow Enhancers Foster Robustness of Drosophila Gastrulation

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The Genetics of Transcription Factor DNA Binding Variation

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Genetic dissection of the α-globin super-enhancer in vivo

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The cis-Regulatory Atlas of the Mouse Immune System

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Enhancer Divergence and cis-Regulatory Evolution in the Human and Chimp Neural Crest

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Multiplexed Engineering and Analysis of Combinatorial Enhancer Activity in Single Cells

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Enhancer biology and enhanceropathies

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Deciphering the multi-scale, quantitative cis-regulatory code

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Global view of enhancer–promoter interactome in human cells

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A High-Resolution Enhancer Atlas of the Developing Telencephalon

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Synchronous and Stochastic Patterns of Gene Activation in the Drosophila Embryo

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Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks

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Chromatin-associated RNAs as facilitators of functional genomic interactions

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Multiple enhancers ensure precision of gap gene-expression patterns in the <i>Drosophila</i> embryo

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Enhancer redundancy in development and disease

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CRX ChIP-seq reveals the <i>cis</i>-regulatory architecture of mouse photoreceptors

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Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes

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Disentangling the Many Layers of Eukaryotic Transcriptional Regulation

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A unified architecture of transcriptional regulatory elements

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Noncanonical Compensation of Zygotic X Transcription in Early Drosophila melanogaster Development Revealed through Single-Embryo RNA-Seq

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Spatially resolved epigenomic profiling of single cells in complex tissues

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Super-enhancers include classical enhancers and facilitators to fully activate gene expression

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Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo

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Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genesPreprint

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Evolutionary conservation of the eumetazoan gene regulatory landscapePreprint

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Zelda overcomes the high intrinsic nucleosome barrier at enhancers during Drosophila zygotic genome activationPreprint

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STAT3, STAT4, NFATc1, and CTCF Regulate PD-1 through Multiple Novel Regulatory Regions in Murine T Cells

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Enhancer Logic and Mechanics in Development and Disease

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Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells

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Epigenomic Comparison Reveals Activation of “Seed” Enhancers during Transition from Naive to Primed Pluripotency

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Extensive conservation of ancient microsynteny across metazoans due to <i>cis</i> -regulatory constraints

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Regulatory Logic of Pan-Neuronal Gene Expression in C. elegans

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Evolution of Alu Elements toward Enhancers

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Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease

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Syntax compensates for poor binding sites to encode tissue specificity of developmental enhancers

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Enhancer grammar in development, evolution, and disease: dependencies and interplay

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Mechanisms of transcriptional precision in animal development

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3D enhancer-promoter interactions and multi-connected hubs: Organizational principles and functional roles

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An Integrated Holo-Enhancer Unit Defines Tissue and Gene Specificity of the Fgf8 Regulatory Landscape

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How the Dorsal gradient works: Insights from postgenome technologies

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Transcriptional enhancers in development and disease

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Shadow enhancers: Frequently asked questions about distributed <i>cis</i>‐regulatory information and enhancer redundancy

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Enhancer Variants Synergistically Drive Dysfunction of a Gene Regulatory Network In Hirschsprung Disease

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A Multiplexed Assay for Exon Recognition Reveals that an Unappreciated Fraction of Rare Genetic Variants Cause Large-Effect Splicing Disruptions

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Zelda Potentiates Morphogen Activity by Increasing Chromatin Accessibility

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Promoter or enhancer, what’s the difference? Deconstruction of established distinctions and presentation of a unifying model

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Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog)

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Epigenomic annotation of gene regulatory alterations during evolution of the primate brain

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High conservation of transcription factor binding and evidence for combinatorial regulation across six Drosophila species

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Cross-species analysis of enhancer logic using deep learning

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A computational pipeline for comparative ChIP-seq analyses

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Partially Redundant Enhancers Cooperatively Maintain Mammalian Pomc Expression Above a Critical Functional Threshold

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Multiplex Enhancer Interference Reveals Collaborative Control of Gene Regulation by Estrogen Receptor α-Bound Enhancers

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Super-enhancers: critical roles and therapeutic targets in hematologic malignancies

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Hold out the genome: a roadmap to solving the cis-regulatory code

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Chromatin and epigenetic features of long-range gene regulation

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Constrained vertebrate evolution by pleiotropic genes

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Enhancer Domains Predict Gene Pathogenicity and Inform Gene Discovery in Complex Disease

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Affinity-optimizing enhancer variants disrupt development

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Dense and pleiotropic regulatory information in a developmental enhancer

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Mechanisms of mutational robustness in transcriptional regulation

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Testing the super-enhancer concept

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The Drosophila Pioneer Factor Zelda Modulates the Nuclear Microenvironment of a Dorsal Target Enhancer to Potentiate Transcriptional Output

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How to make stripes: deciphering the transition from non-periodic to periodic patterns in Drosophila segmentation

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Neural progenitors adopt specific identities by directly repressing all alternative progenitor transcriptional programs

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Multi-enhancer transcriptional hubs confer phenotypic robustness

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E D B

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Shadow enhancers' objective seems to be to establish robust growth patterns independent of genetic or environmental stressPreprint

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Enhancer redundancy in development and disease

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In Brief

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