The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
Abstract
Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) constitute the core components of the PI3K/AKT/mTOR signalling cascade, regulating cell proliferation, survival and metabolism. Although these functions are well-defined in the context of tumorigenesis, recent studies – in particular those using pluripotent stem cells – have highlighted the importance of this pathway to development and cellular differentiation. Here, we review the recent in vitro and in vivo evidence for the role PI3K/AKT/mTOR signalling plays in the control of pluripotency and differentiation, with a particular focus on the molecular mechanisms underlying these functions.
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Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury.
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Metadata
- Authors
- Yu, J. S. L., & Cui, W.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2016-09-01
- Volume
- 143
- Issue
- 17
- Pages
- 3050-3060
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2510435007
- Cited by
- 1,135
- References
- 14
- FWCI
- 34.01
- Type
- journal article
- Language
- en
- Open access
- closed
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