Cited by 147Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerCancer and biochemical research

The metabolic landscape of lung cancer: New insights in a disturbed glucose metabolism

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Vanhove, Karolien, Graulus, Geert-Jan, Mesotten, Liesbet, Thomeer, Michiel, Derveaux, Elien, Noben, Jean-Paul, Guedens, Wanda, Adriaensens, Peter·2019·Frontiers in Oncology

Abstract

Metabolism encompasses the biochemical processes that allow healthy cells to keep energy, redox balance and building blocks required for cell development, survival, and proliferation steady. Malignant cells are well-documented to reprogram their metabolism and energy production networks to support rapid proliferation and survival in harsh conditions via mutations in oncogenes and inactivation of tumor suppressor genes. Despite the histologic and genetic heterogeneity of tumors, a common set of metabolic pathways sustain the high proliferation rates observed in cancer cells. This review with a focus on lung cancer covers several fundamental principles of the disturbed glucose metabolism, such as the "Warburg" effect, the importance of the glycolysis and its branching pathways, the unanticipated gluconeogenesis and mitochondrial metabolism. Furthermore, we highlight our current understanding of the disturbed glucose metabolism and how this might result in the development of new treatments.

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Crossref · 10.3389/fonc.2019.01215

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  1. [58]Harvey A Ferrier D Tricarboxylic acid cycle. In: Harvey RA editor. Biochemistry. 5th Edn. Philadelphia, PA: Lippincott Williams & Wilkins (2011). p. 109– 16.

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Authors
Vanhove, K., Graulus, G.-J., Mesotten, L., Thomeer, M., Derveaux, E., Noben, J.-P., Guedens, W., & Adriaensens, P.
Affiliations
  • Hasselt University (BE)
  • Ziekenhuis Oost-Limburg (BE)
Corresponding author
  • Vanhove, Karolien
  • Adriaensens, Peter
Venue
Frontiers in Oncology
Published
2019-11-15
Volume
9
Pages
1215-1215
ISSN
2234-943X (ISSN-L)
OpenAlex
W2982872965
Cited by
147
References
175
Citations by year
2026: 15 · 2025: 17 · 2024: 18 · 2023: 28 · 2022: 29 · 2021: 21 · 2020: 17 · 2018: 1
FWCI
1.61
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Oncology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Document Server@UHasselt (UHasselt) (submittedVersion, cc-by)
Funders
  • Limburg Sterk Merk
  • Universiteit Hasselt
  • Vlaamse regering
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords
lung cancer, cancer metabolism, glucose metabolism, Warburg effect, glycolysis, gluconeogenesis, mitochondrial metabolism, tumor metabolic reprogramming, metabolic therapy

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