The metabolic landscape of lung cancer: New insights in a disturbed glucose metabolism
Open accessAbstract
Metabolism encompasses the biochemical processes that allow healthy cells to keep energy, redox balance and building blocks required for cell development, survival, and proliferation steady. Malignant cells are well-documented to reprogram their metabolism and energy production networks to support rapid proliferation and survival in harsh conditions via mutations in oncogenes and inactivation of tumor suppressor genes. Despite the histologic and genetic heterogeneity of tumors, a common set of metabolic pathways sustain the high proliferation rates observed in cancer cells. This review with a focus on lung cancer covers several fundamental principles of the disturbed glucose metabolism, such as the "Warburg" effect, the importance of the glycolysis and its branching pathways, the unanticipated gluconeogenesis and mitochondrial metabolism. Furthermore, we highlight our current understanding of the disturbed glucose metabolism and how this might result in the development of new treatments.
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There are ongoing efforts to utilize metabolic reprogramming in NSCLC as a therapeutic opportunity.
“There are a lot of ongoing efforts to utilize the process of metabolic reprogramming in Non-Small Cell Lung Cancer (NSCLC) as a therapeutic opportunity [21,22,23,24].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [23]
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- Authors
- Vanhove, K., Graulus, G.-J., Mesotten, L., Thomeer, M., Derveaux, E., Noben, J.-P., Guedens, W., & Adriaensens, P.
- Affiliations
- Hasselt University (BE)
- Ziekenhuis Oost-Limburg (BE)
- Corresponding author
- Vanhove, Karolien
- Adriaensens, Peter
- ORCID
- Venue
- Frontiers in Oncology
- Publisher
- Frontiers Media SA
- Published
- 2019-11-15
- Volume
- 9
- Pages
- 1215-1215
- ISSN
- 2234-943X (ISSN-L)
- PMC
- PMC6873590
- OpenAlex
- W2982872965
- Cited by
- 147
- References
- 175
- Citations by year
- 2026: 15 · 2025: 17 · 2024: 18 · 2023: 28 · 2022: 29 · 2021: 21 · 2020: 17 · 2018: 1
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Oncology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Document Server@UHasselt (UHasselt) (submittedVersion, cc-by)
- Funders
- Limburg Sterk Merk
- Universiteit Hasselt
- Vlaamse regering
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- lung cancer, cancer metabolism, glucose metabolism, Warburg effect, glycolysis, gluconeogenesis, mitochondrial metabolism, tumor metabolic reprogramming, metabolic therapy
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