The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Cellular and molecular mechanisms of tooth root development
Open accessAbstract
The tooth root is an integral, functionally important part of our dentition. The formation of a functional root depends on epithelial-mesenchymal interactions and integration of the root with the jaw bone, blood supply and nerve innervations. The root development process therefore offers an attractive model for investigating organogenesis. Understanding how roots develop and how they can be bioengineered is also of great interest in the field of regenerative medicine. Here, we discuss recent advances in understanding the cellular and molecular mechanisms underlying tooth root formation. We review the function of cellular structure and components such as Hertwig's epithelial root sheath, cranial neural crest cells and stem cells residing in developing and adult teeth. We also highlight how complex signaling networks together with multiple transcription factors mediate tissue-tissue interactions that guide root development. Finally, we discuss the possible role of stem cells in establishing the crown-to-root transition, and provide an overview of root malformations and diseases in humans.
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Citations
Cites
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Investigation of multipotent postnatal stem cells from human periodontal ligament
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SHED: Stem cells from human exfoliated deciduous teeth
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Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis
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Self-citationReiterative signaling and patterning during mammalian tooth morphogenesis
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Orban's oral histology and embryology
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Self-citationThe cutting-edge of mammalian development; how the embryo makes teeth
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Cited by
Regenerative endodontics: a comprehensive review
Kim, S. G., Malek, M., Sigurdsson, A., Lin, L. M., & Kahler, B. (2018) · International Endodontic Journal · doi:10.1111/iej.12954 · Cited by 523
Piezo-catalysis for nondestructive tooth whitening
Wang, Y., Wen, X., Jia, Y., Huang, M., Wang, F., Zhang, X., Bai, Y., Yuan, G., & Wang, Y. (2020) · Nature Communications · doi:10.1038/s41467-020-15015-3 · Cited by 469
Lrp6 Dynamic Expression in Tooth Development and Mutations in Oligodontia
Yu, M., Fan, Z., Wong, S. W., Sun, K., Zhang, L., Liu, H., Feng, H., Liu, Y., & Han, D. (2021) · Journal of Dental Research · doi:10.1177/0022034520970459 · Cited by 41
Metadata
- Authors
- Li, J., Parada, C., & Chai, Y.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2017-02-01
- Volume
- 144
- Issue
- 3
- Pages
- 374-384
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2585159322
- Cited by
- 265
- References
- 74
- FWCI
- 8.25
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
