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Cited by 265

The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.

Cellular and molecular mechanisms of tooth root development

Open access
Li, Jingyuan, Parada, Carolina, Chai, Yang·2017·Development
DOI 10.1242/dev.137216
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Abstract

The tooth root is an integral, functionally important part of our dentition. The formation of a functional root depends on epithelial-mesenchymal interactions and integration of the root with the jaw bone, blood supply and nerve innervations. The root development process therefore offers an attractive model for investigating organogenesis. Understanding how roots develop and how they can be bioengineered is also of great interest in the field of regenerative medicine. Here, we discuss recent advances in understanding the cellular and molecular mechanisms underlying tooth root formation. We review the function of cellular structure and components such as Hertwig's epithelial root sheath, cranial neural crest cells and stem cells residing in developing and adult teeth. We also highlight how complex signaling networks together with multiple transcription factors mediate tissue-tissue interactions that guide root development. Finally, we discuss the possible role of stem cells in establishing the crown-to-root transition, and provide an overview of root malformations and diseases in humans.

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Metadata

Authors
Li, J., Parada, C., & Chai, Y.
Venue
Development
Publisher
The Company of Biologists
Published
2017-02-01
Volume
144
Issue
3
Pages
374-384
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.137216
OpenAlex
W2585159322
Cited by
265
References
74
FWCI
8.25
Type
journal article
Language
en
Open access
green

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