The DOI matches its Crossref record; 269 of the 269 references it cites were found in a registry or an index.
The maternal-to-zygotic transition revisited
Abstract
The development of animal embryos is initially directed by maternal gene products. Then, during the maternal-to-zygotic transition (MZT), developmental control is handed to the zygotic genome. Extensive research in both vertebrate and invertebrate model organisms has revealed that the MZT can be subdivided into two phases, during which very different modes of gene regulation are implemented: initially, regulation is exclusively post-transcriptional and post-translational, following which gradual activation of the zygotic genome leads to predominance of transcriptional regulation. These changes in the gene expression program of embryos are precisely controlled and highly interconnected. Here, we review current understanding of the mechanisms that underlie handover of developmental control during the MZT.
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Citations
Cites
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Self-citationALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION
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“slow-moving ribosomes and directing these transcripts for degradation (Presnyak et al., 2015; Radhakrishnan et al., 2016).”
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Cited by
eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs
Lorenzo-Orts, L., Strobl, M., Steinmetz, B., Leesch, F., Pribitzer, C., Roehsner, J., Schutzbier, M., Dürnberger, G., & Pauli, A. (2023) · EMBO Reports · doi:10.1038/s44319-023-00006-4 · Cited by 23
Metadata
- Authors
- Vastenhouw, N. L., Cao, W. X., & Lipshitz, H. D.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2019-06-01
- Volume
- 146
- Issue
- 11
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2951614277
- Cited by
- 445
- References
- 269
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Open access
- closed
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