The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
A branching gene regulatory network dictating different aspects of a neuronal cell identity
Abstract
The nervous system displays a daunting cellular diversity. Neuronal subtypes differ from each other in several aspects, including their neurotransmitter expression and axon projection. These aspects can converge, but can also diverge, such that neurons expressing the same neurotransmitter may project axons to different targets. It is not well understood how regulatory programs converge/diverge to associate/dissociate different cell fate features. Studies of the Drosophila Tv1 neurons have identified a regulatory cascade, ladybird early→collier→apterous/eyes absent→dimmed, that specifies Tv1 neurotransmitter expression. Here, we conduct genetic and transcriptome analysis to address how other aspects of Tv1 cell fate are governed. We find that an initiator terminal selector gene triggers a feedforward loop that branches into different subroutines, each of which establishes different features of this one unique neuronal cell fate.
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“Similarly, in the Drosophila brain, complex regulatory cascades of gene expression establish specific features of Tv1 neurons such as neurite morphology or neurotransmitter identity (55).”
From Behavior-related gene regulatory networks: A new level of organization in the brain (2020) · cites this paper as [55]
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Behavior-related gene regulatory networks: A new level of organization in the brain
Sinha, S., Jones, B. M., Traniello, I. M., Bukhari, S. A., Halfon, M. S., Hofmann, H. A., Huang, S., Katz, P. S., Keagy, J., Lynch, V. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921625117 · Cited by 85
Metadata
- Authors
- Stratmann, J., Ekman, H., & Thor, S.
- Affiliations
- Linkoping University 1 Department of Clinical and Experimental Medicine , , SE-581 85 Linkoping , Sweden
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2019-03-15
- Volume
- 146
- Issue
- 6
- ISSN
- 1477-9129
- 0950-1991
- Cited by
- 11
- References
- 63
- Language
- en
- Funders
- University of Iowa (2017-0440601)
- Vetenskapsrådet (621-2013-5258, 2017-04061)
- Knut och Alice Wallenbergs Stiftelse (KAW2011.0165, KAW2017.0312, KAW2012.0101)
- Cancerfonden (140780, 150663, CAN2017/257)
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