The molecular and gene regulatory signature of a neuron
Open accessAbstract
Neuron-type specific gene batteries define the morphological and functional diversity of cell types in the nervous system. Here, we discuss the composition of neuron-type specific gene batteries and illustrate gene regulatory strategies which determine the unique gene expression profiles and molecular composition of individual neuronal cell types from C. elegans to higher vertebrates. Based on principles learned from prokaryotic gene regulation, we argue that neuronal terminal gene batteries are functionally grouped into parallel-acting 'regulons'. The theoretical concepts discussed here provide testable hypotheses for future experimental analysis of the exact gene-regulatory mechanisms employed in the generation of neuronal diversity and identity.
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Once mature, comparable positive feedback can act within single cells to keep different neuronal phenotypes sharply distinct.
“In the mature state, similar positive feedback loops can operate cell autonomously to enforce sharp separation between diverse neuronal phenotypes (Hobert et al., 2010).”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Hobert et al., 2010
The identity and physiological state of neuron types are largely determined by their patterns of gene expression.
“To a large extent, the identity and physiological state of neuron types are determined by their patterns of gene expression (Nelson et al., 2006, Hobert et al., 2010).”
From Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain (2012) · cites this paper as Hobert et al., 2010
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- Authors
- Hobert, O., Carrera, I., & Stefanakis, N.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Hobert, Oliver
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 33
- Issue
- 10
- Pages
- 435-445
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC2947585
- OpenAlex
- W2065819397
- Cited by
- 109
- References
- 73
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 8 · 2015: 5 · 2014: 14 · 2013: 14 · 2012: 9
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS050266, R01NS039996)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- neuronal cell types, gene regulatory networks, regulon, neuronal heterogeneity, neuronal identity, gene expression profiles, prokaryotic gene regulation, Caenorhabditis elegans, vertebrates
- MeSH terms
- Animals, Cell Differentiation, Gene Expression Regulation, Genes, Regulator, Humans, Molecular Sequence Data, Neurons, Gene Expression Profiling, Regulatory Elements, Transcriptional
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