The DOI matches its Crossref record; 156 of the 156 references it cites were found in a registry or an index.
Establishing neuronal diversity in the spinal cord: a time and a place
Open accessAbstract
The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types arranged in characteristic positions. During development, these different types of neurons differentiate from transcriptionally distinct neural progenitors that are arrayed in discrete domains along the dorsal-ventral and anterior-posterior axes of the embryonic spinal cord. This organization arises in response to morphogen gradients acting upstream of a gene regulatory network, the architecture of which determines the spatial and temporal pattern of gene expression. In recent years, substantial progress has been made in deciphering the regulatory network that underlies the specification of distinct progenitor and neuronal cell identities. In this Review, we outline how distinct neuronal cell identities are established in response to spatial and temporal patterning systems, and outline novel experimental approaches to study the emergence and function of neuronal diversity in the spinal cord.
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“These approaches also allow investigation of the molecular and cellular basis of complex pathologies, including microcephaly, autism spectrum disorders and schizophrenia (Di Lullo and Kriegstein, 2017; Fatehullah et al., 2016; Lancaster and Knoblich, 2014).”
BackgroundMolecular Architecture of the Mouse Nervous System
Zeisel, A., Hochgerner, H., Lönnerberg, P., Johnsson, A., Memic, F., van der Zwan, J., Häring, M., Braun, E., Borm, L. E., La Manno, G., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.021 · Cited by 2,552
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Molecular diversity and specializations among the cells of the adult mouse brain
Saunders, A., Macosko, E. Z., Wysoker, A., Goldman, M., Krienen, F. M., de Rivera, H., Bien, E., Baum, M., Bortolin, L., Wang, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.028 · Cited by 1,531 · cited 1×
“These techniques have enabled the generation of highresolution atlases of adult and developing tissues (Clark et al., 2019; Cusanovich et al., 2018; Muñoz-Manchado et al., 2018; Rosenberg et al., 2018; Saunders et al., 2018; Shekhar et al., 2016), and even entire developing embryos (Cao et al.”
BackgroundOrganoids as an in vitro model of human development and disease
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What is a cell type and how to define it?
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A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS
Mark, B., Lai, S.-L., Zarin, A. A., Manning, L., Pollington, H. Q., Litwin-Kumar, A., Cardona, A., Truman, J. W., & Doe, C. Q. (2021) · eLife · doi:10.7554/elife.67510 · Cited by 70
Shekhar, K., Whitney, I. E., Butrus, S., Peng, Y.-R., & Sanes, J. R. (2022) · eLife · doi:10.7554/elife.73809 · Cited by 68
Single-cell transcriptomic landscape of the developing human spinal cord
Andersen, J., Thom, N., Shadrach, J. L., Chen, X., Onesto, M. M., Amin, N. D., Yoon, S.-J., Li, L., Greenleaf, W. J., Müller, F., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01311-w · Cited by 61
Developmental Formation of the GABAergic and Glycinergic Networks in the Mouse Spinal Cord
Shimizu-Okabe, C., Kobayashi, S., Kim, J., Kosaka, Y., Sunagawa, M., Okabe, A., & Takayama, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020834 · Cited by 22
Serotonin signaling at cilia synapses
DeLong, K., & Sheu, S.-H. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.102994 · Cited by 7
Metadata
- Authors
- Sagner, A., & Briscoe, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2019-11-15
- Volume
- 146
- Issue
- 22
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2990650992
- Cited by
- 281
- References
- 156
- FWCI
- 9.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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