The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Gastrulation in the mouse : Growth and regionalization of the epiblast
Abstract
Histological determination of cell numbers in the mouse embryo between and days post coitum show that growth during this period, in which gastrulation occurs, is not uniform. Prior to primitive streak formation mean cell generation time is about 9 h. Co-incidental with the appearance of the primitive streak the embryo enters a period of rapid growth, lasting about 24 h, during which the mean cell generation time must be about 5 h in order to account for the increase in cell numbers. A more detailed study, in which variations in mitotic activity in different regions of the embryo have been analysed, has identified a small region, the so-called ‘proliferative zone’, constituting about 10 % of the whole epiblast, in which cell generation time may average as little as 2·3 h over a 24 h period. The cell generation time for other epiblast regions is estimated at about 6·5 h. It is calculated that the proliferative zone, in the 24 h period commencing with primitive streak formation, could generate about half the cells in the -day embryo. The topographical consequences of such a rapidly expanding region in the embryo are discussed in the light of other, circumstantial evidence, and it is postulated that the cells generated in the PZ may constitute the ectoderm of later stage embryos.
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Cites
Estimation of nuclear population from microtome sections
Abercrombie, M. (1946) · The Anatomical Record · doi:10.1002/ar.1090940210 · Cited by 4,363
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Brown, E. J., & Baltimore, D. (2000) · Genes & Development · doi:10.1101/gad.14.4.397 · Cited by 951
Thomas, P. Q., Brown, A., & Beddington, R. S. P. (1998) · Development · doi:10.1242/dev.125.1.85 · Cited by 528
Reijns, M. A. M., Rabe, B., Rigby, R. E., Mill, P., Astell, K. R., Lettice, L. A., Boyle, S., Leitch, A., Keighren, M., Kilanowski, F., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.011 · Cited by 466
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A single-embryo, single-cell time-resolved model for mouse gastrulation
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Bulut-Karslioglu, A., Macrae, T. A., Oses-Prieto, J. A., Covarrubias, S., Percharde, M., Ku, G., Diaz, A., McManus, M. T., Burlingame, A. L., & Ramalho-Santos, M. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.02.004 · Cited by 97
Sousa-Nunes, R. (2003) · Genome Research · doi:10.1101/gr.1362303 · Cited by 31
Metadata
- Authors
- Snow, M. H. L.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1977-12-01
- Volume
- 42
- Issue
- 1
- Pages
- 293-303
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1956965851
- Cited by
- 351
- References
- 1
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
