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Cited by 550

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Proliferation and migration of primordial germ cells during compensatory growth in mouse embryos

Tam, P. P. L., Snow, M. H. L.·1981·Development

Abstract

Primitive-streak-stage mouse embryos were treated with Mitomycin C injected intraperitoneally into pregnant females at 6·75–7·0 days post coitum. The newborn mice developed poorly and mortality was high during the suckling period. Many weaned survivors showed impaired fertility and poor breeding performance. Histological examination revealed a paucity of germ cells in the adult gonads. The deficiency was mainly caused by a severe reduction of the primordial germ cell population in early embryonic life, which was not fully compensated for during the compensatory growth phase of the Mitomycin C-treated embryo. Also contributing to such impaired fertility were retarded migration of the primordial germ cells into the genital ridges, poor development of the foetal gonad and secondary loss of the germ cells during gametogenesis in males.

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Crossref · 10.1242/dev.64.1.133

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Metadata

Authors
Tam, P. P. L., & Snow, M. H. L.
Venue
Development
Published
1981-08-01
Volume
64
Issue
1
Pages
133-147
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
OpenAlex
W2182720429
Cited by
550
References
1
FWCI
2.86
Type
journal article
Language
en
Open access
closed

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