The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
The relationship between cleavage, DNA replication, and gene expression in the mouse 2-cell embryo
Abstract
The 2-cell stage of mouse embryogenesis is characterized by two phases of α-amanitin-sensitive polypeptide synthetic activity, which appear to mark the first major expression of the embryonic genome, as assessed by examination of in vitro translates of mRNA. Using populations of embryos synchronized to the first cleavage division, we have established that DNA replication takes place over the period 1 to 5 ·5 h after the first cleavage division; the two bursts of putative transcription take place before and immediately after DNA replication, and the translation products are detectable in each case within 3 –4 h. In addition, we have shown that suppression of cytokinesis and the second round of DNA replication does not affect synthesis of the α-amanitin-sensitive polypeptides, and that neither DNA replication nor the loss of maternal mRNA that take place during the 2-cell stage are dependent upon synthesis of the α-amanitin-sensitive polypeptides.
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Cites
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A major developmental transition in early xenopus embryos: II. control of the onset of transcription
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Cited by
Ke, Y., Xu, Y., Chen, X., Feng, S., Liu, Z., Sun, Y., Yao, X., Li, F., Zhu, W., Gao, L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.06.029 · Cited by 522
Parameters controlling transcriptional activation during early drosophila development
Edgar, B. (1986) · Cell · doi:10.1016/0092-8674(86)90009-7 · Cited by 371
Johnson, M. H., & Nasresfahani, M. H. (1994) · BioEssays · doi:10.1002/bies.950160105 · Cited by 342
Self-citationA Subcortical Maternal Complex Essential for Preimplantation Mouse Embryogenesis
Li, L., Baibakov, B., & Dean, J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.07.010 · Cited by 326
Hearn, J. P., Webley, G. E., & Gidley-Baird, A. A. (1991) · Reproduction · doi:10.1530/jrf.0.0920497 · Cited by 46
Metadata
- Authors
- Bolton, V. N., Oades, P. J., & Johnson, M. H.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1984-02-01
- Volume
- 79
- Issue
- 1
- Pages
- 139-163
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2158130862
- Cited by
- 300
- References
- 34
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bolton, V. N., Oades, P. J., & Johnson, M. H. (1984). The relationship between cleavage, DNA replication, and gene expression in the mouse 2-cell embryo. Development. https://doi.org/10.1242/dev.79.1.139
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
