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Small eyes (Sey) : a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse
Abstract
Small eyes (Sey) is a semidominant, homozygous lethal mutation in the mouse (Roberts, 1967). It is allelic with SeyH, a radiation-induced homozygous prenatal lethal which has been mapped on chromosome 2. The effect of the Sey mutation is apparently limited to the growth and differentiation of the presumptive lens and nasal placodes. Homozygous Sey/Sey embryos can be distinguished as early as 10·5 days post coitum (p.c.f, the optic vesicles grow out, but the ectoderm does not give rise to a lens and nasal pits never form. Immunohistochemical studies show that the distribution of the extracellular matrix glycoprotein laminin is not significantly different in the cephalic region of Sey/Sey versus Sey/+ or +/+ embryos. Sey/Sey embryos develop to term but without eyes or nose, and die soon after birth. Further analysis of Sey/Sey embryos may throw light on the mechanisms underlying morphogenesis of craniofacial structures in mammals.
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Citations
Cited by
Xu, P.-X., Woo, I., Her, H., Beier, D. R., & Maas, R. L. (1997) · Development · doi:10.1242/dev.124.1.219 · Cited by 331
Depew, M. J., Tucker, A. S., & Sharpe, P. T. (2002) · Mouse Development · doi:10.1016/b978-012597951-1/50023-8 · Cited by 259
Six3 overexpression initiates the formation of ectopic retina
Loosli, F., Winkler, S., & Wittbrodt, J. (1999) · Genes & Development · doi:10.1101/gad.13.6.649 · Cited by 257
Medaka eyeless is the key factor linking retinal determination and eye growth
Loosli, F., Winkler, S., Burgtorf, C., Wurmbach, E., Ansorge, W., Henrich, T., Grabher, C., Arendt, D., Carl, M., Krone, A., et al. (2001) · Development · doi:10.1242/dev.128.20.4035 · Cited by 135
Lhx2, an evolutionarily conserved, multifunctional regulator of forebrain development
Chou, S.-J., & Tole, S. (2019) · Brain Research · doi:10.1016/j.brainres.2018.02.046 · Cited by 74
Metadata
- Authors
- Hogan, B. L. M., Horsburgh, G., Cohen, J., Hetherington, C. M., Fisher, G., & Lyon, M. F.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1986-09-01
- Volume
- 97
- Issue
- 1
- Pages
- 95-110
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2139125991
- Cited by
- 344
- References
- 0
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Small eyes (Sey) : a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse. https://app.cochat.ai/papers/10.1242/dev.97.1.95
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- Hogan, B. L. M., Horsburgh, G., Cohen, J., Hetherington, C. M., Fisher, G., & Lyon, M. F. (1986). Small eyes (Sey) : a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse. Development. https://doi.org/10.1242/dev.97.1.95
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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