Craniofacial Development

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y.-H., Inada, M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80258-5 · Cited by 4,244 · see citing works

Novel Regulators of Bone Formation: Molecular Clones and Activities

Wozney, J. M., Rosen, V., Celeste, A. J., Mitsock, L. M., Whitters, M. J., Kriz, R., Hewick, R. M., & Wang, E. A. (1988) · Science · doi:10.1126/science.3201241 · Cited by 3,874 · see citing works

TGF-β signalling from cell membrane to nucleus through SMAD proteins

Heldin, C., Miyazono, K., & ten Dijke, P. (1997) · Nature · doi:10.1038/37284 · Cited by 3,697 · see citing works

The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

Cano, A., Pérez‐Moreno, M., Rodrigo, I., Locascio, A., Blanco, M. J., Barrio, M. G. D., Portillo, F., & Nieto, M. A. (2000) · Nature Cell Biology · doi:10.1038/35000025 · Cited by 3,672 · see citing works

The RXR heterodimers and orphan receptors

Mangelsdorf, D. J., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90200-7 · Cited by 3,165 · see citing works

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Chiang, C. C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., & Beachy, P. A. (1996) · Nature · doi:10.1038/383407a0 · Cited by 3,062 · see citing works

Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development

Otto, F., Thornell, A., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G., Beddington, R. S. P., Mundlos, S., Olsen, B. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80259-7 · Cited by 2,813 · see citing works

Sonic hedgehog mediates the polarizing activity of the ZPA

Riddle, R. D., Johnson, R. L., Laufer, E., & Tabin, C. J. (1993) · Cell · doi:10.1016/0092-8674(93)90626-2 · Cited by 2,285 · see citing works

Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal

Cohen, S. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83739-0 · Cited by 2,202 · see citing works

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A., & McMahon, A. P. (1993) · Cell · doi:10.1016/0092-8674(93)90627-3 · Cited by 2,154 · see citing works

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

Hahn, H., Wicking, C., Zaphiropoulos, P. G., Gailani, M. R., Shanley, S., Chidambaram, A., Vořechovský, I., Holmberg, E., Undén, A. B., Gillies, S. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81268-4 · Cited by 2,018 · see citing works

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

Vortkamp, A., Lee, K., Lanske, B., Segre, G. V., Kronenberg, H. M., & Tabin, C. J. (1996) · Science · doi:10.1126/science.273.5275.613 · Cited by 1,999 · see citing works

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

Soriano, P. M., Montgomery, C. A., Geske, R. S., & Bradley, A. (1991) · Cell · doi:10.1016/0092-8674(91)90499-o · Cited by 1,997 · see citing works

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789 · see citing works

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.Preprint

Winnier, G. E., Blessing, M., Labosky, P. A., & Hogan, B. L. M. (1995) · Genes & Development · doi:10.1101/gad.9.17.2105 · Cited by 1,789 · see citing works

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formationPreprint

St‐Jacques, B., Hammerschmidt, M., & McMahon, A. P. (1999) · Genes & Development · doi:10.1101/gad.13.16.2072 · Cited by 1,742 · see citing works

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

Zimmerman, L. B., Jesús-Escobar, J. M. D., & Harland, R. M. (1996) · Cell · doi:10.1016/s0092-8674(00)80133-6 · Cited by 1,639 · see citing works

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

McMahon, A. P., & Bradley, A. (1990) · Cell · doi:10.1016/0092-8674(90)90385-r · Cited by 1,540 · see citing works

Growth factors from murine sarcoma virus-transformed cells.

Larco, J. E. D., & Todaro, G. J. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.8.4001 · Cited by 1,474 · see citing works

Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis

Chai, Y., Jiang, X., Ito, Y., Bringas, P., Han, J., Rowitch, D. H., Soriano, P. M., McMahon, A. P., & Sucov, H. M. (2000) · Development · doi:10.1242/dev.127.8.1671 · Cited by 1,464 · see citing works

Interneuron Migration from Basal Forebrain to Neocortex: Dependence on <i>Dlx</i> Genes

Anderson, S. A., Eisenstat, D. D., Shi, L., & Rubenstein, J. L. R. (1997) · Science · doi:10.1126/science.278.5337.474 · Cited by 1,462 · see citing works

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

Sanford, L. P., Ormsby, I., Groot, A. C. G.-D., Sariola, H., Friedman, R., Boivin, G. P., Cardell, E. L., & Doetschman, T. (1997) · Development · doi:10.1242/dev.124.13.2659 · Cited by 1,447 · see citing works

HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo

Bitgood, M. J., & McMahon, A. P. (1995) · Developmental Biology · doi:10.1006/dbio.1995.0010 · Cited by 1,370 · see citing works

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

Porter, J. A., Young, K. E., & Beachy, P. A. (1996) · Science · doi:10.1126/science.274.5285.255 · Cited by 1,360 · see citing works

PTH/PTHrP Receptor in Early Development and Indian Hedgehog—Regulated Bone Growth

Lanske, B., Karaplis, A. C., Lee, K., Luz, A., Vortkamp, A., Pirro, A. E., Karperien, M., Defize, L. H. K., Ho, C., Mulligan, R. C., et al. (1996) · Science · doi:10.1126/science.273.5275.663 · Cited by 1,325 · see citing works

Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia.

Shiang, R., Thompson, L., Zhu, Y.-Z., Church, D., Fielder, T., Bocian, M., Winokur, S., & Wasmuth, J. (1994) · Cell · doi:10.1016/0092-8674(94)90302-6 · Cited by 1,291 · see citing works

Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development

Satokata, I., & Maas, R. L. (1994) · Nature Genetics · doi:10.1038/ng0494-348 · Cited by 1,274 · see citing works

Erratum: Mouse Small eye results from mutation in a paired-like homebox-containing gene

Hill, R. E., Favor, J., Hogan, B. L. M., Ton, C. C. T., Saunders, G. F., Hanson, I. M., Prosser, J., Jordan, T., Hastie, N. D., & van Heyningen, V. (1992) · Nature · doi:10.1038/355750a0 · Cited by 1,270 · see citing works

c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling

Grigoriadis, A. E., Wang, Z., Cecchini, M. G., Hofstetter, W., Felix, R., Fleisch, H. A., & Wagner, E. F. (1994) · Science · doi:10.1126/science.7939685 · Cited by 1,260 · see citing works

The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.Preprint

Kimura, S., Hara, Y., Pineau, T., Fernández‐Salguero, P. M., Fox, C. H., Ward, J. M., & Gonzalez, F. J. (1996) · Genes & Development · doi:10.1101/gad.10.1.60 · Cited by 1,221 · see citing works

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

Crossley, P. H., & Martin, G. R. (1995) · Development · doi:10.1242/dev.121.2.439 · Cited by 1,177 · see citing works

Mouse Small eye results from mutations in a paired-like homeobox-containing gene

Hill, R. E., Favor, J., Hogan, B. L. M., Ton, C. C. T., Saunders, G. F., Hanson, I. M., Prosser, J., Jordan, T., Hastie, N. D., & van Heyningen, V. (1991) · Nature · doi:10.1038/354522a0 · Cited by 1,159 · see citing works

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.Preprint

Karaplis, A. C., Luz, A., Glowacki, J., Bronson, R. T., Tybulewicz, V. L. J., Kronenberg, H. M., & Mulligan, R. C. (1994) · Genes & Development · doi:10.1101/gad.8.3.277 · Cited by 1,151 · see citing works

Patterning the Vertebrate Neuraxis

Lumsden, A., & Krumlauf, R. K. (1996) · Science · doi:10.1126/science.274.5290.1109 · Cited by 1,142 · see citing works

A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.Preprint

Dudley, A. T., Lyons, K. M., & Robertson, E. J. (1995) · Genes & Development · doi:10.1101/gad.9.22.2795 · Cited by 1,135 · see citing works

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.Preprint

Levéen, P., Pekny, M., Gebré‐Medhin, S., Swolin, B., Larsson, E., & Betsholtz, C. (1994) · Genes & Development · doi:10.1101/gad.8.16.1875 · Cited by 1,130 · see citing works

Origin of luteinizing hormone-releasing hormone neurons

Schwanzel-Fukuda, M., & Pfaff, D. W. (1989) · Nature · doi:10.1038/338161a0 · Cited by 1,116 · see citing works

Embryonic retinoic acid synthesis is essential for early mouse post-implantation development

Niederreither, K., Subbarayan, V., Dollé, P., & Chambon, P. (1999) · Nature Genetics · doi:10.1038/7788 · Cited by 1,111 · see citing works

Tetracycline-based histological analysis of bone remodeling

Frost, H. M. (1969) · Calcified Tissue Research · doi:10.1007/bf02058664 · Cited by 1,111 · see citing works

Fibroblast growth factor receptor 3 is a negative regulator of bone growth.

Deng, C.-X., Wynshaw-Boris, A., Zhou, F., Kuo, A., & Leder, P. (1996) · Cell · doi:10.1016/s0092-8674(00)81069-7 · Cited by 1,095 · see citing works

Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm

Liem, K. F., Tremml, G., Roelink, H., & Jessell, T. M. (1995) · Cell · doi:10.1016/0092-8674(95)90276-7 · Cited by 1,071 · see citing works

Neural Crest and the Origin of Vertebrates: A New Head

Gans, C., & Northcutt, R. G. (1983) · Science · doi:10.1126/science.220.4594.268 · Cited by 1,053 · see citing works

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

Kaartinen, V., Voncken, J. W., Shuler, C. F., Warburton, D., Bu, D., Heisterkamp, N., & Groffen, J. (1995) · Nature Genetics · doi:10.1038/ng1295-415 · Cited by 1,042 · see citing works

The triple origin of skull in higher vertebrates: a study in quail-chick chimeras

Couly, G. F., Coltey, P. M., & Douarin, N. M. L. (1993) · Development · doi:10.1242/dev.117.2.409 · Cited by 1,032 · see citing works

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.Preprint

van Genderen, C., Okamura, R., Fariñas, I., Quo, R. G., Parslow, T., Bruhn, L., & Grosschedl, R. (1994) · Genes & Development · doi:10.1101/gad.8.22.2691 · Cited by 1,031 · see citing works

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

Dickson, M. C., Martin, J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S., & Akhurst, R. J. (1995) · Development · doi:10.1242/dev.121.6.1845 · Cited by 1,029 · see citing works

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.Preprint

Luo, G., Hofmann, C., Bronckers, A. L. J. J., Sohocki, M. M., Bradley, A., & Karsenty, G. (1995) · Genes & Development · doi:10.1101/gad.9.22.2808 · Cited by 1,020 · see citing works

Requirement for NF-κB in osteoclast and B-cell development

Franzoso, G., Carlson, L., Xing, L., Poljak, L., Shores, E. W., Brown, K. D., Leonardi, A., Tran, T., Boyce, B. F., & Siebenlist, U. (1997) · Genes &amp; Development · doi:10.1101/gad.11.24.3482 · Cited by 996 · see citing works

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

Zhang, H., & Bradley, A. (1996) · Development · doi:10.1242/dev.122.10.2977 · Cited by 988 · see citing works

Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1

Kurihara, Y., Kurihara, H., Suzuki, H. I., Kodama, T., Maemura, K., Nagai, R., Oda, H., Kuwaki, T., Cao, W.-H., Kamada, N., et al. (1994) · Nature · doi:10.1038/368703a0 · Cited by 981 · see citing works

A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo

Yamaguchi, T. P., Bradley, A., McMahon, A. P., & Jones, S. J. M. (1999) · Development · doi:10.1242/dev.126.6.1211 · Cited by 971 · see citing works

Development, Function and Evolution of Teeth

Madden, R. H., Teaford, M. F., Smith, M. M., & Ferguson, M. W. J. (2001) · Palaios · doi:10.2307/3515582 · Cited by 942 · see citing works

The Olfactory Bulb: Coding and Processing of Odor Molecule Information

Mori, K., Nagao, H., & Yoshihara, Y. (1999) · Science · doi:10.1126/science.286.5440.711 · Cited by 937 · see citing works

Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome

Wilkie, A., Slaney, S., Oldridge, M., Poole, M., Ashworth, G., Hockley, A., Hayward, R., David, D., Pulleyn, L., Rutland, P., et al. (1995) · Nature Genetics · doi:10.1038/ng0295-165 · Cited by 933 · see citing works

Bone and haematopoietic defects in mice lacking c-fos

Wang, Z., Ovitt, C. E., Grigoriadis, A. E., Möhle-Steinlein, U., Rüther, U., & Wagner, E. F. (1992) · Nature · doi:10.1038/360741a0 · Cited by 932 · see citing works

Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development

Vainio, S. J., Karavanova, I. D., Jowett, A. K., & Thesleff, I. (1993) · Cell · doi:10.1016/s0092-8674(05)80083-2 · Cited by 923 · see citing works

Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia

Rousseau, F., Bonaventure, J., Legeai-Mallet, L., Pelet, A., Rozet, J., Maroteaux, P., Merrer, M. L., & Munnich, A. (1994) · Nature · doi:10.1038/371252a0 · Cited by 920 · see citing works

New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.

Roberts, A. B., Anzano, M. A., Lamb, L. C., Smith, J. M., & Sporn, M. B. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.9.5339 · Cited by 919 · see citing works

Transforming growth factor–β3 is required for secondary palate fusion

Proetzel, G., Pawlowski, S. A., Wiles, M. V., Yin, M., Boivin, G. P., Howles, P. N., Ding, J., Ferguson, M. W. J., & Doetschman, T. (1995) · Nature Genetics · doi:10.1038/ng1295-409 · Cited by 908 · see citing works

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

Thomas, K. R., & Capecchi, M. R. (1990) · Nature · doi:10.1038/346847a0 · Cited by 896 · see citing works

Pax-2 controls multiple steps of urogenital development

Torres, M., Gómez‐Pardo, E., Dressler, G. R., & Gruß, P. (1995) · Development · doi:10.1242/dev.121.12.4057 · Cited by 895 · see citing works

The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues

Noden, D. M. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90318-4 · Cited by 878 · see citing works

Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome

Semina, E. V., Reiter, R. S., Leysens, N. J., Alward, W. L. M., Small, K. W., Datson, N. A., Siegel‐Bartelt, J., BIERKE‐NELSON, D., Bitoun, P., Zabel, B., et al. (1996) · Nature Genetics · doi:10.1038/ng1296-392 · Cited by 876 · see citing works

PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis

Boström, H., Willetts, K., Pekny, M., Levéen, P., Lindahl, P., Hedstrand, H., Pekna, M., Hellström, M., Gebre-Medhin, S., Schalling, M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81270-2 · Cited by 864 · see citing works

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

Chisaka, O., & Capecchi, M. R. (1991) · Nature · doi:10.1038/350473a0 · Cited by 853 · see citing works

Segmental patterns of neuronal development in the chick hindbrain

Lumsden, A., & Keynes, R. J. (1989) · Nature · doi:10.1038/337424a0 · Cited by 852 · see citing works

Teratogen-Mediated Inhibition of Target Tissue Response to <i>Shh</i> Signaling

Cooper, M. K., Porter, J. A., Young, K. E., & Beachy, P. A. (1998) · Science · doi:10.1126/science.280.5369.1603 · Cited by 848 · see citing works

Pax9 -deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalitiesPreprint

Peters, H., Neubüser, A., Kratochwil, K., & Balling, R. (1998) · Genes & Development · doi:10.1101/gad.12.17.2735 · Cited by 829 · see citing works

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.Preprint

Goodrich, L. V., Johnson, R. L., Milenković, L., McMahon, J. A., & Scott, M. P. (1996) · Genes & Development · doi:10.1101/gad.10.3.301 · Cited by 825 · see citing works

Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase

Hu, Y., Baud, V., Delhase, M., Zhang, P., Deerinck, T. J., Ellisman, M. H., Johnson, R. S., & Karin, M. (1999) · Science · doi:10.1126/science.284.5412.316 · Cited by 822 · see citing works

Noggin, Cartilage Morphogenesis, and Joint Formation in the Mammalian Skeleton

Brunet, L. J., McMahon, J. A., McMahon, A. P., & Harland, R. M. (1998) · Science · doi:10.1126/science.280.5368.1455 · Cited by 822 · see citing works

Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid

Cho, K. W. Y., Blumberg, B., Steinbeißer, H., & Robertis, E. M. D. (1991) · Cell · doi:10.1016/0092-8674(91)90288-a · Cited by 807 · see citing works

Sonic hedgehog regulates growth and morphogenesis of the tooth

Dassule, H. R., Lewis, P. M., Bei, M., Maas, R. L., & McMahon, A. P. (2000) · Development · doi:10.1242/dev.127.22.4775 · Cited by 806 · see citing works

The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas

Sosa‐Pineda, B., Chowdhury, K., Torres, M., Oliver, G. C., & Gruß, P. (1997) · Nature · doi:10.1038/386399a0 · Cited by 804 · see citing works

Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse

Dattani, M., Martı́nez-Barberá, J. P., Thomas, P. Q., Brickman, J. M., Gupta, R., Mårtensson, I., Toresson, H., Fox, M., Wales, J. K., Hindmarsh, P. C., et al. (1998) · Nature Genetics · doi:10.1038/477 · Cited by 790 · see citing works

A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse

Conlon, F. L., Lyons, K. M., Takaesu, N. T., Barth, K. S., Kispert, A., Herrmann, B. G., & Robertson, E. J. (1994) · Development · doi:10.1242/dev.120.7.1919 · Cited by 772 · see citing works

Control of Cell Behavior During Vertebrate Development by Slug , a Zinc Finger Gene

Nieto, M. A., Sargent, M. G., Wilkinson, D. G., & Cooke, J. (1994) · Science · doi:10.1126/science.7513443 · Cited by 770 · see citing works

Function of the retinoic acid receptors (RARs) during development: (I) Craniofacial and skeletal abnormalities in RAR double mutants

Lohnes, D., Mark, M. P., Mendelsohn, C. L., Dollé, P., Dierich, A., Gorry, P., Gansmüller, A., & Chambon, P. (1994) · Development · doi:10.1242/dev.120.10.2723 · Cited by 764 · see citing works

sprouty Encodes a Novel Antagonist of FGF Signaling that Patterns Apical Branching of the Drosophila Airways

Hacohen, N., Krämer, S., Sutherland, D., Hiromi, Y., & Krasnow, M. A. (1998) · Cell · doi:10.1016/s0092-8674(00)80919-8 · Cited by 750 · see citing works

X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein

Kere, J., Srivastava, A. K., Montonen, O., Zonana, J., Thomas, N., Ferguson, B., Munoz, F., Morgan, D., Clarke, A., Baybayan, P., et al. (1996) · Nature Genetics · doi:10.1038/ng0895-409 · Cited by 749 · see citing works

Axis Development and Early Asymmetry in Mammals

Beddington, R. S. P., & Robertson, E. J. (1999) · Cell · doi:10.1016/s0092-8674(00)80560-7 · Cited by 746 · see citing works

Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome

Reardon, W., Winter, R., Rutland, P., Pulleyn, L., Jones, B., & Malcolm, S. (1994) · Nature Genetics · doi:10.1038/ng0994-98 · Cited by 746 · see citing works

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

Satokata, I., Ma, L., Ohshima, H., Bei, M., Woo, I., Nishizawa, K., Maeda, T., Takano, Y., Uchiyama, M., Heaney, S., et al. (2000) · Nature Genetics · doi:10.1038/74231 · Cited by 737 · see citing works

neurogenin1 Is Essential for the Determination of Neuronal Precursors for Proximal Cranial Sensory Ganglia

Ma, Q., Chen, Z., Barrantes, I. D. B., de la Pompa, J. L., & Anderson, D. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80988-5 · Cited by 735 · see citing works

Evidence that cells expressing luteinizing hormone-releasing hormone mRNA in the mouse are derived from progenitor cells in the olfactory placode.

Wray, S., Grant, P. G., & Gainer, H. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.8132 · Cited by 717 · see citing works

Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND

Srivastava, D., Thomas, T., Lin, Q., Kirby, M. L., Brown, D., & Olson, E. N. (1997) · Nature Genetics · doi:10.1038/ng0697-154 · Cited by 715 · see citing works

Bone morphogenetic proteins in development

Hogan, B. L. M. (1996) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(96)80064-5 · Cited by 715 · see citing works

The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites

Soriano, P. M. (1997) · Development · doi:10.1242/dev.124.14.2691 · Cited by 709 · see citing works

Contributions of placodal and neural crest cells to avian cranial peripheral ganglia

D'amico‐Martel, A., & Noden, D. M. (1983) · American Journal of Anatomy · doi:10.1002/aja.1001660406 · Cited by 708 · see citing works

A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene

Hui, C., & Joyner, A. L. (1993) · Nature Genetics · doi:10.1038/ng0393-241 · Cited by 707 · see citing works

Forebrain and midbrain regions are deleted in Otx2−/− mutants due to a defective anterior neuroectoderm specification during gastrulation

Acampora, D., Mazan, S., Lallemand, Y., Avantaggiato, V., Maury, M., Simeone, A., & Brûlet, P. (1995) · Development · doi:10.1242/dev.121.10.3279 · Cited by 702 · see citing works

Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression

Lufkin, T., Dierich, A., LeMeur, M., Mark, M. P., & Chambon, P. (1991) · Cell · doi:10.1016/0092-8674(91)90034-v · Cited by 696 · see citing works

A transcriptional partner for MAD proteins in TGF-β signalling

Chen, X., Rubock, M. J., & Whitman, M. (1996) · Nature · doi:10.1038/383691a0 · Cited by 694 · see citing works

Wnt signalling required for expansion of neural crest and CNS progenitors

Ikeya, M., Lee, S. M. K., Johnson, J. E. B., McMahon, A. P., & Takada, S. (1997) · Nature · doi:10.1038/40146 · Cited by 684 · see citing works

Mouse Otx2 functions in the formation and patterning of rostral head.Preprint

Matsuo, I., Kuratani, S., Kimura, C., Takeda, N., & Aizawa, S. (1995) · Genes & Development · doi:10.1101/gad.9.21.2646 · Cited by 684 · see citing works

Spatial organization of the epithelium and the role of neural crest cells in the initiation of the mammalian tooth germ

Lumsden, A. G. S. (1988) · Development · doi:10.1242/dev.103.supplement.155 · Cited by 676 · see citing works

Bone morphogenetic proteins in development

Šimić, P., & Vukičević, S. (2004) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7857-9_4 · Cited by 674 · see citing works

A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis

Jabs, E. W., Müller, U., Li, X., Ma, L., Luo, W., Haworth, I. S., Klisak, I. J., Sparkes, R. S., Warman, M. L., Mulliken, J. B., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90379-5 · Cited by 673 · see citing works

Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo

Sasaki, H., & Hogan, B. L. M. (1993) · Development · doi:10.1242/dev.118.1.47 · Cited by 672 · see citing works

splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3

Epstein, D. J., Vekemans, M. J. J., & Gros, P. (1991) · Cell · doi:10.1016/0092-8674(91)90071-6 · Cited by 670 · see citing works

The role of Pax-6 in eye and nasal development

Grindley, J. C., Davidson, D. R., & Hill, R. E. (1995) · Development · doi:10.1242/dev.121.5.1433 · Cited by 669 · see citing works

Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny

Koentges, G., & Lumsden, A. (1996) · Development · doi:10.1242/dev.122.10.3229 · Cited by 668 · see citing works

Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

Aza‐Blanc, P., Ramı́rez-Weber, F.-A., Laget, M.-P., Schwartz, C. J. E., & Kornberg, T. B. (1997) · Cell · doi:10.1016/s0092-8674(00)80292-5 · Cited by 661 · see citing works

Five years on the wings of fork head

Kaufmann, E., & Knöchel, W. (1996) · Mechanisms of Development · doi:10.1016/0925-4773(96)00539-4 · Cited by 660 · see citing works

Inductive interactions direct early regionalization of the mouse forebrain

Shimamura, K., & Rubenstein, J. L. R. (1997) · Development · doi:10.1242/dev.124.14.2709 · Cited by 659 · see citing works

Signalling networks regulating dental development

Thesleff, I., & Sharpe, P. T. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00115-9 · Cited by 650 · see citing works

Mutations in TWIST, a basic helix–loop–helix transcription factor, in Saethre-Chotzen syndrome

Howard, T. D., Paznekas, W. A., Green, E. D., Chiang, L. C., Ma, N. S. F., Luna, R. I. O. D., Delgado, C. G., Gonzalez-Ramos, M., Kline, A. D., & Jabs, E. W. (1997) · Nature Genetics · doi:10.1038/ng0197-36 · Cited by 645 · see citing works

Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryoPreprint

Sun, X., Meyers, E. N., Lewandoski, M. B., & Martin, G. R. (1999) · Genes & Development · doi:10.1101/gad.13.14.1834 · Cited by 644 · see citing works

Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice

Clouthier, D. E., Hosoda, K., Richardson, J. A., Williams, S. C., Yanagisawa, H., Kuwaki, T., Kumada, M., Hammer, R. E., & Yanagisawa, M. (1998) · Development · doi:10.1242/dev.125.5.813 · Cited by 643 · see citing works

Mutations of the TWIST gene in the Saethre-Chotzene syndrome

Ghouzzi, V. E., Merrer, M. F. L., Perrin‐Schmitt, F., Lajeunie, E., Bénit, P., Rénier, D., Bourgeois, P., Bolcato‐Bellemin, A., Münnich, A., & Bonaventure, J. (1997) · Nature Genetics · doi:10.1038/ng0197-42 · Cited by 639 · see citing works

Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo

Lumsden, A., Sprawson, N., & Graham, A. (1991) · Development · doi:10.1242/dev.113.4.1281 · Cited by 634 · see citing works

Gli1 is a target of Sonic hedgehog that induces ventral neural tube development

Lee, J. D., Platt, K. A., Censullo, P., & Altaba, A. R. I. (1997) · Development · doi:10.1242/dev.124.13.2537 · Cited by 633 · see citing works

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

Johnson, R. S., Spiegelman, B. M., & Papaioannou, V. E. (1992) · Cell · doi:10.1016/0092-8674(92)90592-z · Cited by 630 · see citing works

A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene

Rijli, F. M., Mark, M. P., Lakkaraju, S., Dierich, A., Dollé, P., & Chambon, P. (1993) · Cell · doi:10.1016/0092-8674(93)90620-6 · Cited by 630 · see citing works

Follicular cells of the thyroid gland require Pax8 gene function

Mansouri, A., Chowdhury, K., & Gruß, P. (1998) · Nature Genetics · doi:10.1038/ng0598-87 · Cited by 620 · see citing works

A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo.

Simeone, A., Acampora, D., Mallamaci, A., Stornaiuolo, A., D’Apice, M. R., Nigro, V., & Boncinelli, E. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05935.x · Cited by 616 · see citing works

twist is required in head mesenchyme for cranial neural tube morphogenesis.Preprint

Chen, Z., & Behringer, R. R. (1995) · Genes & Development · doi:10.1101/gad.9.6.686 · Cited by 616 · see citing works

Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals

Bürglin, T. R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.21.4173 · Cited by 615 · see citing works

A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome

Muenke, M., Schell, U., Hehr, A., Robin, N. H., Losken, H. W., Schinzel, A., Pulleyn, L. J., Rutland, P., Reardon, W., Malcolm, S., et al. (1994) · Nature Genetics · doi:10.1038/ng1194-269 · Cited by 614 · see citing works

Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis

Lin, C. R., Kioussi, C., O’Connell, S. M., Briata, P., Szeto, D. P., Liu, F. C., Izpisúa‐Belmonte, J. C., & Rosenfeld, M. G. (1999) · Nature · doi:10.1038/45803 · Cited by 612 · see citing works

Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors

Seifert, R. A., Hart, C. E., Phillips, P. E., Forstrom, J. W., Ross, R., Murray, M. J., & Bowen‐Pope, D. F. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81860-9 · Cited by 610 · see citing works

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development

Mo, R., Freer, A. M., Zinyk, D. L., Crackower, M. A., Michaud, J. L., Heng, H. H., Chik, K. W., Shi, X., Tsui, L., Cheng, S. H., et al. (1997) · Development · doi:10.1242/dev.124.1.113 · Cited by 607 · see citing works

Combinatorial expression of three zebrafish genes related to distal- less: part of a homeobox gene code for the head

Akimenko, M., Ekker, M., Wegner, J., Lin, W., & Westerfield, M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03475.1994 · Cited by 606 · see citing works

Limb and Skin Abnormalities in Mice Lacking IKKα

Takeda, K., Takeuchi, O., Tsujimura, T., Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K., Terada, N., & Akira, S. (1999) · Science · doi:10.1126/science.284.5412.313 · Cited by 606 · see citing works

Antagonistic Interactions between FGF and BMP Signaling Pathways: A Mechanism for Positioning the Sites of Tooth Formation

Neubüser, A., Peters, H., Balling, R., & Martin, G. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80333-5 · Cited by 606 · see citing works

Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres

Xuan, S., Baptista, C., Balas, G., Tao, W., Soares, V., & Lai, E. (1995) · Neuron · doi:10.1016/0896-6273(95)90262-7 · Cited by 600 · see citing works

Function of retinoic acid receptor γ in the mouse

Lohnes, D., Kastner, P., Dierich, A., Mark, M. P., LeMeur, M., & Chambon, P. (1993) · Cell · doi:10.1016/0092-8674(93)90246-m · Cited by 598 · see citing works

The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal

Alcedo, J., Ayzenzon, M., Ohlen, T. L. V., Noll, M., & Hooper, J. E. (1996) · Cell · doi:10.1016/s0092-8674(00)80094-x · Cited by 598 · see citing works

Smad2 role in mesoderm formation, left–right patterning and craniofacial development

Nomura, M., & Li, E. (1998) · Nature · doi:10.1038/31693 · Cited by 597 · see citing works

Different phenotypes for mice deficient in either activins or activin receptor type II

Matzuk, M. M., Kumar, T. R., & Bradley, A. (1995) · Nature · doi:10.1038/374356a0 · Cited by 589 · see citing works

Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation.

Sampath, T. K., & Reddi, A. H. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.12.7599 · Cited by 588 · see citing works

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.Preprint

Sander, M., Neubüser, A., Kalamaras, J., Ee, H. C., Martin, G. R., & German, M. S. (1997) · Genes & Development · doi:10.1101/gad.11.13.1662 · Cited by 588 · see citing works

The midbrain-hindbrain phenotype of Wnt-1−Wnt-1− mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum

McMahon, A. P., Joyner, A. L., Bradley, A., & McMahon, J. A. (1992) · Cell · doi:10.1016/0092-8674(92)90222-x · Cited by 584 · see citing works

Multiple defects and perinatal death in mice deficient in follistatin

Matzuk, M. M., Lu, N., Vogel, H. S., Sellheyer, K., Roop, D. R., & Bradley, A. (1995) · Nature · doi:10.1038/374360a0 · Cited by 584 · see citing works

Functional analysis of activins during mammalian development

Matzuk, M. M., Kumar, T. R., Vassalli, A., Bickenbach, J. R., Roop, D. R., Jaenisch, R., & Bradley, A. (1995) · Nature · doi:10.1038/374354a0 · Cited by 578 · see citing works

Retinoic acid receptors and cellular retinoid binding proteins: I. A systematic study of their differential pattern of transcription during mouse organogenesis

Dollé, P., Ruberte, E., Leroy, P., Morriss‐Kay, G. M., & Chambon, P. (1990) · Development · doi:10.1242/dev.110.4.1133 · Cited by 574 · see citing works

High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice.

Lufkin, T., Lohnes, D., Mark, M., Dierich, A., Gorry, P., Gaub, M., Lemeur, M., & Chambon, P. (1993) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.90.15.7225 · Cited by 573 · see citing works

Genetical studies on the skeleton of the mouse

Grüneberg, H. (1954) · Journal of Genetics · doi:10.1007/bf02981536 · Cited by 558 · see citing works

The induction of odontogenesis in non-dental mesenchyme combined with early murine mandibular arch epithelium

Mina, M., & Kollar, E. J. (1987) · Archives of Oral Biology · doi:10.1016/0003-9969(87)90055-0 · Cited by 554 · see citing works

Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest

Gendron‐Maguire, M., Mallo, M., Zhang, M., & Gridley, T. (1993) · Cell · doi:10.1016/0092-8674(93)90619-2 · Cited by 550 · see citing works

Autoproteolysis in hedgehog protein biogenesis

Lee, J., Ekker, S. C., von Kessler, D. P., Porter, J. A., Sun, B. I., & Beachy, P. A. (1994) · Science · doi:10.1126/science.7985023 · Cited by 547 · see citing works

Mutations of the Homeobox Genes Dlx-1 and Dlx-2 Disrupt the Striatal Subventricular Zone and Differentiation of Late Born Striatal Neurons

Anderson, S. A., Qiu, M. S., Bulfone, A., Eisenstat, D. D., Meneses, J. J., Pedersen, R. A., & Rubenstein, J. L. R. (1997) · Neuron · doi:10.1016/s0896-6273(00)80345-1 · Cited by 545 · see citing works

REGIONALIZATION OF THE PROSENCEPHALIC NEURAL PLATE

Rubenstein, J. L. R., Shimamura, K., Martı́nez, S., & Puelles, L. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.445 · Cited by 543 · see citing works

The world according to bedgebog

Hammerschmidt, M., Brook, A., & McMahon, A. P. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(96)10051-2 · Cited by 542 · see citing works

A Subclass of bHLH Proteins Required for Cardiac Morphogenesis

Srivastava, D., Cserjesi, P., & Olson, E. N. (1995) · Science · doi:10.1126/science.270.5244.1995 · Cited by 539 · see citing works

Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox geneHox-#150;1.6

Chisaka, O., Musci, T. S., & Capecchi, M. R. (1992) · Nature · doi:10.1038/355516a0 · Cited by 536 · see citing works

The Embryonic Vertebrate Forebrain: the Prosomeric Model

Rubenstein, J. L. R., Martinez, S., Shimamura, K., & Puelles, L. (1994) · Science · doi:10.1126/science.7939711 · Cited by 535 · see citing works

Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia

Naski, M., Wang, Q., Xu, J.-S., & Ornitz, D. (1996) · Nature Genetics · doi:10.1038/ng0696-233 · Cited by 525 · see citing works

Craniosynostosis: genes and mechanisms

Wilkie, A. O. M. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.10.1647 · Cited by 523 · see citing works

Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development

Niederreither, K., McCaffery, P., Dräger, U. C., Chambon, P., & Dollé, P. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(96)00653-3 · Cited by 523 · see citing works

The organizer factors Chordin and Noggin are required for mouse forebrain development

Bachiller, D., Klingensmith, J., Kemp, C. R., Belo, J. A., Anderson, R. M., May, S. R., McMahon, J. A., McMahon, A. P., Harland, R. M., Rossant, J., et al. (2000) · Nature · doi:10.1038/35001072 · Cited by 521 · see citing works

Retinoic acid receptors and cellular retinoid binding proteins : II. Their differential pattern of transcription during early morphogenesis in mouse embryos

Ruberte, E., Dollé, P., Chambon, P., & Morriss‐Kay, G. M. (1991) · Development · doi:10.1242/dev.111.1.45 · Cited by 516 · see citing works

Nodal signalling in vertebrate development

Schier, A. F., & Shen, M. M. (2000) · Nature · doi:10.1038/35000126 · Cited by 515 · see citing works

Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial archPreprint

Trumpp, A., Depew, M. J., Rubenstein, J. L. R., Bishop, J. M., & Martin, G. R. (1999) · Genes & Development · doi:10.1101/gad.13.23.3136 · Cited by 515 · see citing works

GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome

Kang, S., Graham, J. M., Olney, A. H., & Biesecker, L. G. (1997) · Nature Genetics · doi:10.1038/ng0397-266 · Cited by 509 · see citing works

NEUROGENIN1 and NEUROGENIN2 control two distinct waves of neurogenesis in developing dorsal root gangliaPreprint

Ma, Q., Schuurmans, C. J., Guillemot, F., & Anderson, D. J. (1999) · Genes & Development · doi:10.1101/gad.13.13.1717 · Cited by 509 · see citing works

Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed

Minowada, G., Jarvis, L. A., Chi, C. L., Neubüser, A., Sun, X., Hacohen, N., Krasnow, M. A., & Martin, G. R. (1999) · Development · doi:10.1242/dev.126.20.4465 · Cited by 506 · see citing works

Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells

Bober, E., Franz, T., Arnold, H.-H., Gruß, P., & Tremblay, P. J. (1994) · Development · doi:10.1242/dev.120.3.603 · Cited by 506 · see citing works

Function of Rieger syndrome gene in left–right asymmetry and craniofacial development

Lu, M.-F., Pressman, C. L., Dyer, R. B., Johnson, R. L., & Martin, J. F. (1999) · Nature · doi:10.1038/45797 · Cited by 504 · see citing works

Neural crest induction in Xenopus: evidence for a two-signal model

LaBonne, C., & Bronner-Fraser, M. E. (1998) · Development · doi:10.1242/dev.125.13.2403 · Cited by 502 · see citing works

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain

Ang, S., Jin, O., Rhinn, M., Daigle, N., Stevenson, L., & Rossant, J. (1996) · Development · doi:10.1242/dev.122.1.243 · Cited by 500 · see citing works

A distinct Hox code for the branchial region of the vertebrate head

Hunt, P., Gulisano, M., Cook, M., Sham, M. H., Faiella, A., Wilkinson, D. G., Boncinelli, E., & Krumlauf, R. K. (1991) · Nature · doi:10.1038/353861a0 · Cited by 498 · see citing works

Embryonic gene expression patterns of TGF β1, β2 and β3 suggest different developmental functions in vivo

Millan, F. A., Denhez, F., Kondaiah, P., & Akhurst, R. J. (1991) · Development · doi:10.1242/dev.111.1.131 · Cited by 498 · see citing works

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryoPreprint

Sirard, C., de la Pompa, J. L., Elia, A., Itié, A., Mirtsos, C., Cheung, A., Hahn, S. A., Wakeham, A. C., Schwartz, L., Kern, S. E., et al. (1998) · Genes & Development · doi:10.1101/gad.12.1.107 · Cited by 498 · see citing works

Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

Lasorella, A., Noseda, M., Beyna, M., & Iavarone, A. (2000) · Nature · doi:10.1038/35036504 · Cited by 497 · see citing works

Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene

Yanagisawa, H., Yanagisawa, M., Kapur, R. P., Richardson, J. A., Williams, S. C., Clouthier, D. E., de Wit, D., Emoto, N., & Hammer, R. E. (1998) · Development · doi:10.1242/dev.125.5.825 · Cited by 490 · see citing works

The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGFβ superfamily

Kingsley, D. M., Bland, A. E., Grubber, J. M., Marker, P. C., Russell, L. B., Copeland, N. G., & Jenkins, N. A. (1992) · Cell · doi:10.1016/0092-8674(92)90510-j · Cited by 482 · see citing works

The embryonic origins of avian cephalic and cervical muscles and associated connective tissues

Noden, D. M. (1983) · American Journal of Anatomy · doi:10.1002/aja.1001680302 · Cited by 480 · see citing works

Expression of Three Mouse Homologs of the Drosophila Segment Polarity Gene cubitus interruptus, Gli, Gli-2, and Gli-3, in Ectoderm- and Mesoderm-Derived Tissues Suggests Multiple Roles during Postimplantation Development

Hui, C., Slusarski, D. C., Platt, K. A., Holmgren, R. A., & Joyner, A. L. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1097 · Cited by 480 · see citing works

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

van den Heuvel, M., & Ingham, P. W. (1996) · Nature · doi:10.1038/382547a0 · Cited by 475 · see citing works

Differential expression of genes encoding α, β and γ retinoic acid receptors and CRABP in the developing limbs of the mouse

Dollé, P., Ruberte, E., Kastner, P., Petkovich, M. P., Stoner, C. M., Gudas, L. J., & Chambon, P. (1989) · Nature · doi:10.1038/342702a0 · Cited by 474 · see citing works

Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate.Preprint

Zhou, P., Byrne, C. R., Jacobs, J., & Fuchs, E. V. (1995) · Genes & Development · doi:10.1101/gad.9.6.700 · Cited by 474 · see citing works

Vital dye analysis of cranial neural crest cell migration in the mouse embryo

Serbedzija, G. N., Bronner-Fraser, M. E., & Fraser, S. E. (1992) · Development · doi:10.1242/dev.116.2.297 · Cited by 473 · see citing works

Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo

Conlon, R. A., & Rossant, J. (1992) · Development · doi:10.1242/dev.116.2.357 · Cited by 469 · see citing works

Sprouty, an intracellular inhibitor of Ras signaling

Casci, T., Vinós, J., & Freeman, M. (1999) · Cell · doi:10.1016/s0092-8674(00)80576-0 · Cited by 467 · see citing works

Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo

Waldrip, W. R., Bikoff, E. K., Hoodless, P. A., Wrana, J. L., & Robertson, E. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81407-5 · Cited by 460 · see citing works

Role of the Dlx Homeobox Genes in Proximodistal Patterning of the Branchial Arches: Mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 Alter Morphogenesis of Proximal Skeletal and Soft Tissue Structures Derived from the First and Second Arches

Qiu, M. S., Bulfone, A., Ghattas, I. R., Meneses, J. J., Christensen, L., Sharpe, P. T., Presley, R., Pedersen, R. A., & Rubenstein, J. L. R. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8556 · Cited by 460 · see citing works

Transformation of Tooth Type Induced by Inhibition of BMP Signaling

Tucker, A. S., Matthews, K. L., & Sharpe, P. T. (1998) · Science · doi:10.1126/science.282.5391.1136 · Cited by 458 · see citing works

Indian Hedgehog coordinates endochondral bone growth and morphogenesis via Parathyroid Hormone related-Protein-dependent and -independent pathways

Karp, S. J., Schipani, E., St‐Jacques, B., Hunzelman, J. L., Kronenberg, H. M., & McMahon, A. P. (2000) · Development · doi:10.1242/dev.127.3.543 · Cited by 458 · see citing works

The Vomeronasal Organ

Keverne, E. B. (1999) · Science · doi:10.1126/science.286.5440.716 · Cited by 457 · see citing works

Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity

Marshall, H., Nonchev, S., Sham, M. H., Muchamore, I., Lumsden, A., & Krumlauf, R. K. (1992) · Nature · doi:10.1038/360737a0 · Cited by 455 · see citing works

Analysis of the early stages of trunk neural crest migration in avian embryos using monoclonal antibody HNK-1

Bronner-Fraser, M. E. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90226-5 · Cited by 455 · see citing works

Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2

Jabs, E., Li, X., Scott, A., Meyers, G., Chen, W. T., Eccles, M., Mao, J., Charnas, L., Jackson, C., & Jaye, M. (1994) · Nature Genetics · doi:10.1038/ng1194-275 · Cited by 452 · see citing works

Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome

Hahn, H., Wojnowski, L., Zimmer, A. M., Hall, J., Miller, G., & Zimmer, A. (1998) · Nature Medicine · doi:10.1038/nm0598-619 · Cited by 451 · see citing works

The origin and evolution of animal appendages

Panganiban, G. E. F., Irvine, S. M., Lowe, C. J., Roehl, H. H., Lavine, L. C., Sherbon, B. J., Grenier, J. K., Fallon, J. F., Kimble, J. E., Walker, M. H., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5162 · Cited by 450 · see citing works

Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites

Johnson, R. L., Laufer, E., Riddle, R. D., & Tabin, C. J. (1994) · Cell · doi:10.1016/0092-8674(94)90008-6 · Cited by 449 · see citing works

Seven-Transmembrane Proteins as Odorant and Chemosensory Receptors

Mombaerts, P. (1999) · Science · doi:10.1126/science.286.5440.707 · Cited by 446 · see citing works

Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear

Mansour, S. L., Goddard, J. M., & Capecchi, M. R. (1993) · Development · doi:10.1242/dev.117.1.13 · Cited by 446 · see citing works

The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot

Jernvall, J., Åberg, T., Kettunen, P. J., Keränen, S. V. E., & Thesleff, I. (1998) · Development · doi:10.1242/dev.125.2.161 · Cited by 445 · see citing works

Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins

Mann, R. S., & Chan, S.-K. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)10026-3 · Cited by 444 · see citing works

The bHLH Protein NEUROGENIN 2 Is a Determination Factor for Epibranchial Placode–Derived Sensory Neurons

Schuurmans, C. J., Gradwohl, G., Morin, X., Dierich, A., LeMeur, M., Goridis, C., & Guillemot, F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80989-7 · Cited by 444 · see citing works

Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5

Acampora, D., Merlo, G. R., Paleari, L., Zerega, B., Postiglione, M. P., Mantero, S., Bober, E., Barbieri, O., Simeone, A., & Levi, G. (1999) · Development · doi:10.1242/dev.126.17.3795 · Cited by 444 · see citing works

Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes

Rutland, P., Pulleyn, L., Reardon, W., Baraitser, M., Hayward, R., Jones, B., Malcolm, S., Winter, R., Oldridge, M., Slaney, S., et al. (1995) · Nature Genetics · doi:10.1038/ng0295-173 · Cited by 443 · see citing works

Engrailed, Wnt and Pax genes regulate midbrain-hindbrain development

Joyner, A. L. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)81383-7 · Cited by 439 · see citing works

Regulation of organogenesis. Common molecular mechanisms regulating the development of teeth and other organs

Thesleff, I., Vaahtokari, A., & Partanen, A. (1995) · The International Journal of Developmental Biology · doi:10.1387/ijdb.7626420 · Cited by 436 · see citing works

The Influence of Extracellular Matrix on Gene Expression: Is Structure The Message?

Bissell, M. J., & Barcellos‐Hoff, M. H. (1987) · Journal of Cell Science · doi:10.1242/jcs.1987.supplement_8.18 · Cited by 436 · see citing works

Origins of the avian neural crest: the role of neural plate-epidermal interactions

Selleck, M. A. J., & Bronner-Fraser, M. E. (1995) · Development · doi:10.1242/dev.121.2.525 · Cited by 436 · see citing works

Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development

Lyons, K. M., Hogan, B. L. M., & Robertson, E. J. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(94)00326-i · Cited by 427 · see citing works

Shared role of the pRB-related p130 and p107 proteins in limb development.Preprint

Cobrinik, D. E., Lee, M. H., Hannon, G. J., Mulligan, G., Bronson, R. T., Dyson, N. J., Harlow, E. E., Beach, D., Weinberg, R. A., & Jacks, T. (1996) · Genes & Development · doi:10.1101/gad.10.13.1633 · Cited by 426 · see citing works

Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development

Szeto, D. P., Rodriguez-Esteban, C., Ryan, A. K., O'Connell, S. M., Liu, F., Kioussi, C., Gleiberman, A. S., Izpisua-Belmonte, J. C., & Rosenfeld, M. G. (1999) · Genes &amp; Development · doi:10.1101/gad.13.4.484 · Cited by 426 · see citing works

Cell lineage in mammalian craniofacial mesenchyme.

Yoshida, T., Vivatbutsiri, P., Morriss-Kay, G., Saga, Y., & Iseki, S. (2008) · Mechanisms of Development · doi:10.1016/j.mod.2008.06.007 · Cited by 384 · see citing works

Bone Biology and the Clinical Implications for Osteoporosis

Downey, P. A., & Siegel, M. I. (2006) · Physical Therapy · doi:10.1093/ptj/86.1.77 · Cited by 270 · see citing works

The evolutionary role of modularity and integration in the Hominoid cranium

Mitteroecker, P., & Bookstein, F. (2008) · Evolution · doi:10.1111/j.1558-5646.2008.00321.x · Cited by 267 · see citing works

Developmental and Genetic Constraints on Neurocranial Globularity: Insights from Analyses of Deformed Skulls and Quantitative Genetics

Martínez-Abadías, N., Paschetta, C., de Azevedo, S., Esparza, M., & González-José, R. (2009) · Evolutionary Biology · doi:10.1007/s11692-008-9045-4 · Cited by 35 · see citing works

Morphological consequences of artificial cranial deformation: Modularity and integration

Püschel, T. A., Friess, M., & Manríquez, G. (2020) · PLOS ONE · doi:10.1371/journal.pone.0227362 · Cited by 22 · see citing works

Craniofacial modularity, character analysis, and the evolution of the premaxilla in early African hominins

Villmoare, B. A., Dunmore, C., Kilpatrick, S., Oertelt, N., Depew, M. J., & Fish, J. L. (2014) · Journal of Human Evolution · doi:10.1016/j.jhevol.2014.06.014 · Cited by 16 · see citing works

DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION

Mustafa, N. H., Kelesbayev, D., & Alibekova, Z. D. (2018) · The Journal of Economic Research & Business Administration · doi:10.26577/be-2018-2-2141

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

Craniofacial anthropometric analysis in Down's syndrome patients.

Bagić, I. Č., & Verzak, Ž. (2003) · PubMed · Cited by 35 · see citing works

Craniofacial morphology in parents of cleft children and healthy individuals.

Nagle, E., Teibe, U., & Balode, I. (2006) · PubMed · Cited by 3 · see citing works

Using DataGrid Control to Realize DataBase of Querying in VB6.0

Hu, S. (2000) · Modern Computer