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Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction
Abstract
We have isolated Xenopus laevis N-CAM cDNA clones and used these to study the expression of N-CAM RNA during neural induction. The results show that the first marked increase in N-CAM RNA levels occurs during gastrulation when mesoderm comes in contact with ectoderm and induces neural development. In situ hybridization results show that the early expression of N-CAM RNA is localized to the neural plate and its later expression is confined to the neural tube. Induction experiments with explanted germ layers show that N-CAM RNA is not expressed in ectoderm unless there is contact with inducing tissue. Together these results suggest an approach to studying how ectoderm is committed to form neural rather than epidermal tissue. Specifically, the data suggest that neural commitment is marked and perhaps mediated by the transcriptional activation of genes, like N-CAM, in the neural ectoderm.
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Cited by
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824
Amaya, E., Musci, T. J., & Kirschner, M. W. (1991) · Cell · doi:10.1016/0092-8674(91)90616-7 · Cited by 1,085
Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein
Lee, J. E., Hollenberg, S. M., Snider, L., Turner, D. L., Lipnick, N., & Weintraub, H. (1995) · Science · doi:10.1126/science.7754368 · Cited by 1,023
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.
Turner, D. L., & Weintraub, H. (1994) · Genes & Development · doi:10.1101/gad.8.12.1434 · Cited by 1,019
Expression of a Delta homologue in prospective neurons in the chick
Henrique, D., Adam, J., Myat, A., Chitnis, A., Lewis, J., & Ish-Horowicz, D. (1995) · Nature · doi:10.1038/375787a0 · Cited by 992
Metadata
- Authors
- Kintner, C. R., & Melton, D. A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1987-03-01
- Volume
- 99
- Issue
- 3
- Pages
- 311-325
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2125619554
- Cited by
- 480
- References
- 0
- FWCI
- 12.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction. https://app.cochat.ai/papers/10.1242/dev.99.3.311
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- Kintner, C. R., & Melton, D. A. (1987). Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction. Development. https://doi.org/10.1242/dev.99.3.311
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
