The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Beyond the zebrafish: diverse fish species for modeling human disease
Open accessAbstract
Summary: In recent years, zebrafish, and to a lesser extent medaka, have become widely used small animal models for human diseases. These organisms have convincingly demonstrated the usefulness of fish for improving our understanding of the molecular and cellular mechanisms leading to pathological conditions, and for the development of new diagnostic and therapeutic tools. Despite the usefulness of zebrafish and medaka in the investigation of a wide spectrum of traits, there is evidence to suggest that other fish species could be better suited for more targeted questions. With the emergence of new, improved sequencing technologies that enable genomic resources to be generated with increasing efficiency and speed, the potential of non-mainstream fish species as disease models can now be explored. A key feature of these fish species is that the pathological condition that they model is often related to specific evolutionary adaptations. By exploring these adaptations, new disease-causing and disease-modifier genes might be identified; thus, diverse fish species could be exploited to better understand the complexity of disease processes. In addition, non-mainstream fish models could allow us to study the impact of environmental factors, as well as genetic variation, on complex disease phenotypes. This Review will discuss the opportunities that such fish models offer for current and future biomedical research.
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Cites
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Cited by
Sex determination, gonadal sex differentiation, and plasticity in vertebrate species
Nagahama, Y., Chakraborty, T., Paul-Prasanth, B., Ohta, K., & Nakamura, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00044.2019 · Cited by 346
A Platform for Rapid Exploration of Aging and Diseases in a Naturally Short-Lived Vertebrate
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A new model army: Emerging fish models to study the genomics of vertebrate Evo-Devo.
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Parey, E., Louis, A., Montfort, J., Guiguen, Y., Crollius, H. R., & Berthelot, C. (2022) · Genome Research · doi:10.1101/gr.276953.122 · Cited by 83
Zebrafish models of sarcopenia
Daya, A., Donaka, R., & Karasik, D. (2020) · Disease Models & Mechanisms · doi:10.1242/dmm.042689 · Cited by 55
Metadata
- Authors
- Schartl, M.
- Venue
- Disease Models & Mechanisms
- Publisher
- The Company of Biologists
- Published
- 2013-01-01
- Volume
- 7
- Issue
- 2
- Pages
- 181-92
- ISSN
- 1754-8403 (ISSN-L)
- 1754-8411
- OpenAlex
- W1981454034
- Cited by
- 214
- References
- 5
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- gold
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