The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
A peek into cancer-associated fibroblasts: origins, functions and translational impact
Open accessAbstract
In malignant tumors, cancer cells adapt to grow within their host tissue. As a cancer progresses, an accompanying host stromal response evolves within and around the nascent tumor. Among the host stromal constituents associated with the tumor are cancer-associated fibroblasts, a highly abundant and heterogeneous population of cells of mesenchymal lineage. Although it is known that fibroblasts are present from the tumor's inception to the end-stage metastatic spread, their precise functional role in cancer is not fully understood. It has been suggested that cancer-associated fibroblasts play a key role in modulating the behavior of cancer cells, in part by promoting tumor growth, but evolving data also argue for their antitumor actions. Taken together, this suggests a putative bimodal function for cancer-associated fibroblasts in oncogenesis. As illustrated in this Review and its accompanying poster, cancer-associated fibroblasts are a dynamic component of the tumor microenvironment that orchestrates the interplay between the cancer cells and the host stromal response. Understanding the complexity of the relationship between cancer cells and cancer-associated fibroblasts could offer insights into the regulation of tumor progression and control of cancer.
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Metadata
- Authors
- LeBleu, V. S., & Kalluri, R.
- Venue
- Disease Models & Mechanisms
- Publisher
- The Company of Biologists
- Published
- 2018-04-01
- Volume
- 11
- Issue
- 4
- ISSN
- 1754-8403 (ISSN-L)
- 1754-8411
- OpenAlex
- W2801303687
- Cited by
- 537
- References
- 101
- FWCI
- 25.19
- Type
- journal article
- Language
- en
- Open access
- gold
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