The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cadherin switching
Open accessAbstract
The cadherin molecules at adherens junctions have multiple isoforms. Cadherin isoform switching (cadherin switching) occurs during normal developmental processes to allow cell types to segregate from one another. Tumor cells often recapitulate this activity and the result is an aggressive tumor cell that gains the ability to leave the site of the tumor and metastasize. At present, we understand some of the mechanisms that promote cadherin switching and some of the pathways downstream of this process that influence cell behavior. Specific cadherin family members influence growth-factor-receptor signaling and Rho GTPases to promote cell motility and invasion. In addition, p120-catenin probably plays multiple roles in cadherin switching, regulating Rho GTPases and stabilizing cadherins.
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Citations
Cites
Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
Peinado, H., Olmeda, D., & Cano, A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2131 · Cited by 3,121
RHO GTPASES: Biochemistry and Biology
Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009
Steinberg, M. S., & Takeichi, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.206 · Cited by 572
Qian, X., Karpova, T., Sheppard, A. M., McNally, J., & Lowy, D. R. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600136 · Cited by 396
E-cadherin and P-cadherin have partially redundant roles in human epidermal stratification
Jensen, P. J., Telegan, B., Lavker, R. M., & Wheelock, M. J. (1997) · Cell and Tissue Research · doi:10.1007/s004410050816 · Cited by 54
Self-citation
Cited by
Molecular mechanisms of epithelial–mesenchymal transition
Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091
Cadherins and cancer: how does cadherin dysfunction promote tumor progression?
Jeanes, A., Gottardi, C. J., & Yap, A. S. (2008) · Oncogene · doi:10.1038/onc.2008.343 · Cited by 772
Involvement of Members of the Cadherin Superfamily in Cancer
Berx, G., & van Roy, F. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003129 · Cited by 709
Mechanisms of Motility in Metastasizing Cells
Yilmaz, M., & Christofori, G. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0139 · Cited by 477
Hypoxia: Overview on Hypoxia-Mediated Mechanisms with a Focus on the Role of HIF Genes
Tirpe, A. A., Gulei, D., Ciortea, S. M., Crivii, C., & Berindan-Neagoe, I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246140 · Cited by 438
Metadata
- Authors
- Wheelock, M. J., Shintani, Y., Maeda, M., Fukumoto, Y., & Johnson, K. R.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2008-03-15
- Volume
- 121
- Issue
- 6
- Pages
- 727-735
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W4211224216
- Cited by
- 767
- References
- 5
- FWCI
- 19.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
