The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Formins: signaling effectors for assembly and polarization of actin filaments
Abstract
Eukaryotic cells require filamentous actin to maintain their shape and for movement, growth and replication. New actin filaments are formed by the cutting of existing filaments or de novo through the action of specialized nucleators. The most highly characterized nucleator is the Arp2/3 complex,which nucleates the branched actin networks in the lamellae of migrating cells. Recently, Bni1p, which is a member of the formin family of proteins,has been shown to nucleate actin filaments in vitro. Formins are implicated in the formation of actin cables in yeast, stress fibers in tissue culture cells and cytokinesis in many cell types. Formins contain two highly conserved formin-homology domains, FH1 and FH2. The Bni1p FH2 domain is sufficient to mediate nucleation. The Bni1p FH1 domain binds profilin, an actin-monomer-binding protein that delivers actin to the growing barbed end of filaments. The Bni1p FH1-profilin interaction enhances nucleation. Formins participate in a number of signaling pathways that control the assembly of specific actin structures and bind the barbed end of actin filaments, thereby providing a cytoskeletal basis for the establishment of cell polarity.
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Cites
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A double hit implicates DIAPH3 as an autism risk gene
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Metadata
- Authors
- Evangelista, M., Zigmond, S., & Boone, C.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2003-07-01
- Volume
- 116
- Issue
- 13
- Pages
- 2603-2611
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2074622507
- Cited by
- 287
- References
- 90
- FWCI
- 11.05
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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