The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
Rho-family GTPases: it's not only Rac and Rho (and I like it)
Open accessAbstract
The Rho-family proteins make up a major branch of the Ras superfamily of small GTPases. To date, 22 human genes encoding at least 25 proteins have been described. The best known `classical' members are RhoA, Rac1 and Cdc42. Highly related isoforms of these three proteins have not been studied as intensively, in part because it has been assumed that they are functionally identical to their better-studied counterparts. This now appears not to be the case. Variations in C-terminal-signaled modifications and subcellular targeting cause otherwise highly biochemically related isoforms (e.g. RhoA, RhoB and RhoC) to exhibit surprisingly divergent biological activities. Whereas the classical Rho GTPases are regulated by GDP/GTP cycling, other Rho GTPases are also regulated by other mechanisms, particularly by transcriptional regulation. Newer members of the family possess additional sequence elements beyond the GTPase domain, which suggests they exhibit yet other mechanisms of regulation.
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Citations
Cites
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The Guanine Nucleotide-Binding Switch in Three Dimensions
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Genomic analysis of metastasis reveals an essential role for RhoC
Clark, E. A., Golub, T. R., Lander, E. S., & Hynes, R. O. (2000) · Nature · doi:10.1038/35020106 · Cited by 1,445
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Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck
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Cited by
The Ras superfamily at a glance
Wennerberg, K., Rossman, K. L., & Der, C. J. (2005) · Journal of Cell Science · doi:10.1242/jcs.01660 · Cited by 1,352
Self-citationHuman RAS Superfamily Proteins and Related GTPases
Colicelli, J. (2004) · Science's STKE · doi:10.1126/stke.2502004re13 · Cited by 582
Rho GTPases: Regulation and roles in cancer cell biology
Haga, R. B., & Ridley, A. J. (2016) · Small GTPases · doi:10.1080/21541248.2016.1232583 · Cited by 559
Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma
Kakiuchi, M., Nishizawa, T., Ueda, H., Gotoh, K., Tanaka, A., Hayashi, A., Yamamoto, S., Tatsuno, K., Katoh, H., Watanabe, Y., et al. (2014) · Nature Genetics · doi:10.1038/ng.2984 · Cited by 505
Mechanisms of Degranulation in Neutrophils
Lacy, P. (2006) · Allergy, Asthma & Clinical Immunology · doi:10.1186/1710-1492-2-3-98 · Cited by 473
Metadata
- Authors
- Wennerberg, K., & Der, C. J.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2004-03-15
- Volume
- 117
- Issue
- 8
- Pages
- 1301-1312
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2095562167
- Cited by
- 613
- References
- 121
- FWCI
- 15.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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