The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells
Abstract
Rab GTPases control vesicle movement and tethering membrane events in membrane trafficking. We used the 38 human Rab GTPase activating proteins (GAPs) to identify which of the 60 Rabs encoded in the human genome function at the Golgi complex. Surprisingly, this screen identified only two GAPs, RN-tre and TBC1D20, disrupting both Golgi organization and protein transport. RN-tre is the GAP for Rab43, and controls retrograde transport into the Golgi from the endocytic pathway. TBC1D20 is the ER-localized GAP for Rab1, and is the only GAP blocking the delivery of secretory cargo from the ER to the cell surface. Strikingly, its expression causes the loss of the Golgi complex, highlighting the importance of Rab1 for Golgi biogenesis. These effects can be antagonized by reticulon, a binding partner for TBC1D20 in the ER. Together, these findings indicate that Rab1 and Rab43 are key Rabs required for the biogenesis and maintenance of a functional Golgi structure, and suggest that other Rabs acting at the Golgi complex are likely to be functionally redundant.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Loss of RAB1A/B impaired secretion (Fig. 6d,e), serving as a positive control3637.”
From Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival (2016) · cites this paper as [36]
Citations
Cites
Rab proteins as membrane organizers
Zerial, M., & McBride, H. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052055 · Cited by 3,381
The Mechanisms of Vesicle Budding and Fusion
Bonifacino, J. S., & Glick, B. S. (2004) · Cell · doi:10.1016/s0092-8674(03)01079-1 · Cited by 1,908
The Guanine Nucleotide-Binding Switch in Three Dimensions
Vetter, I. R., & Wittinghofer, A. (2001) · Science · doi:10.1126/science.1062023 · Cited by 1,875
α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models
Cooper, A. A., Gitler, A. D., Cashikar, A. G., Haynes, C. M., Hill, K. J., Bhullar, B., Liu, K., Xu, K., Strathearn, K. E., Liu, F., et al. (2006) · Science · doi:10.1126/science.1129462 · Cited by 1,411
A Class of Membrane Proteins Shaping the Tubular Endoplasmic Reticulum
Voeltz, G. K., Prinz, W. A., Shibata, Y., Rist, J. M., & Rapoport, T. A. (2006) · Cell · doi:10.1016/j.cell.2005.11.047 · Cited by 1,133
Tisdale, E. J., Bourne, J. R., Khosravi-Far, R., Der, C. J., & Balch, W. E. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.4.749 · Cited by 500
Targeting Rab GTPases to distinct membrane compartments
Pfeffer, S. R., & Aivazian, D. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1500 · Cited by 462
Transport-vesicle targeting: tethers before SNAREs
Pfeffer, S. R. (1999) · Nature Cell Biology · doi:10.1038/8967 · Cited by 449
The organization of endoplasmic reticulum export complexes.
Bannykh, S. I., Rowe, T., & Balch, W. E. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.1.19 · Cited by 440
Procollagen Traverses the Golgi Stack without Leaving the Lumen of Cisternae
Bonfanti, L., Aa, M., Martínez‐Menárguez, J. A., Martella, O., Fusella, A., Baldassarre, M., Buccione, R., Geuze, H. J., Mirоnоv, A. A., & Luini, A. (1998) · Cell · doi:10.1016/s0092-8674(00)81723-7 · Cited by 419
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–204 of 204
Adaptations of autophagy and lysosomal systems upon membrane damage and pathogenic invasion
Bhattacharya, A. (2023) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.73735
The Important Roles of RTNLBs on the Function Realization of Membranous Organelles in PlantPreprint
Cao, G., Yang, Y., Tao, Z., & Tang, L. (2023) · Research Square · doi:10.21203/rs.3.rs-3445159/v1
Metadata
- Authors
- Haas, A. K., Yoshimura, S.-I., Stephens, D. J., Preisinger, C., Fuchs, E., & Barr, F. A.
- Affiliations
- University of Liverpool (GB)
- University of Bristol (GB)
- Max Planck Institute of Biochemistry (DE)
- Corresponding author
- Barr, Francis A.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2007-09-01
- Volume
- 120
- Issue
- 17
- Pages
- 2997-3010
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2064782801
- Cited by
- 201
- References
- 56
- Citations by year
- 2025: 8 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 11 · 2020: 8 · 2019: 10 · 2018: 9 · 2017: 10 · 2016: 16 · 2015: 9 · 2014: 13 · 2013: 15 · 2012: 21
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed (publishedVersion)
- Explore Bristol Research (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- Rab GTPases, Rab1, Rab GTPase-activating protein, reticulons, retrograde transport, secretory pathway, ER-Golgi transport, membrane trafficking, functional redundancy
- MeSH terms
- rab11 GTP-Binding Proteins, Animals, Biological Transport, Endoplasmic Reticulum, Golgi Apparatus, HeLa Cells, Humans, Nerve Tissue Proteins, Phenotype, Recombinant Fusion Proteins, Genome, Human, rab GTP-Binding Proteins, rab1 GTP-Binding Proteins, Two-Hybrid System Techniques, RNA Interference
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
