The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope
Open accessAbstract
Nesprins form a novel class of nuclear envelope-anchored spectrin-repeat proteins. We show that a direct association of their highly conserved C-terminal luminal domain with the inner nuclear membrane protein Sun1 mediates their nuclear envelope localisation. In Nesprin-1 and Nesprin-2 the conserved C-terminal amino acids PPPX are essential for the interaction with a C-terminal region in Sun1. In fact, Sun1 is required for the proper nuclear envelope localisation of Nesprin-2 as shown using dominant-negative mutants and by knockdown of Sun1 expression. Sun1 itself does not require functional A-type lamins for its localisation at the inner nuclear membrane in mammalian cells. Our findings propose a conserved nuclear anchorage mechanism between Caenorhabditis elegans and mammals and suggest a model in which Sun1 serves as a `structural bridge' connecting the nuclear interior with the actin cytoskeleton.
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Dechat, T., Gotzmann, J., Stockinger, A., Harris, C. A., Ann Talle, M., Siekierka, J. J., & Foisner, R. (1998) · The EMBO Journal · doi:10.1093/emboj/17.16.4887 · Cited by 146
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Cited by
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus
Wang, N., Tytell, J. D., & Ingber, D. E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2594 · Cited by 1,762
Dechat, T., Pfleghaar, K., Sengupta, K., Shimi, T., Shumaker, D. K., Solimando, L., & Goldman, R. D. (2008) · Genes & Development · doi:10.1101/gad.1652708 · Cited by 940
Nuclear Shape, Mechanics, and Mechanotransduction
Dahl, K. N., Ribeiro, A. J. S., & Lammerding, J. (2008) · Circulation Research · doi:10.1161/circresaha.108.173989 · Cited by 708
Lombardi, M. L., Jaalouk, D. E., Shanahan, C. M., Burke, B., Roux, K. J., & Lammerding, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.233700 · Cited by 549
Haque, F., Lloyd, D. J., Smallwood, D. T., Dent, C. L., Shanahan, C. M., Fry, A. M., Trembath, R. C., & Shackleton, S. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.10.3738-3751.2006 · Cited by 503
Metadata
- Authors
- Padmakumar, V. C., Libotte, T., Lu, W., Zaim, H., Abraham, S., Noegel, A. A., Gotzmann, J., Foisner, R., & Karakesisoglou, I.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2005-08-01
- Volume
- 118
- Issue
- 15
- Pages
- 3419-3430
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2116633927
- Cited by
- 409
- References
- 1
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Padmakumar, V. C., Libotte, T., Lu, W., Zaim, H., Abraham, S., Noegel, A. A., Gotzmann, J., Foisner, R., & Karakesisoglou, I. (2005). The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope. Journal of Cell Science. https://doi.org/10.1242/jcs.02471
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