The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Regulating cell migration: calpains make the cut
Abstract
The calpain family of proteases has been implicated in cellular processes such as apoptosis, proliferation and cell migration. Calpains are involved in several key aspects of migration, including: adhesion and spreading; detachment of the rear; integrin- and growth-factor-mediated signaling; and membrane protrusion. Our understanding of how calpains are activated and regulated during cell migration has increased as studies have identified roles for calcium and phospholipid binding, autolysis, phosphorylation and inhibition by calpastatin in the modulation of calpain activity. Knockout and knockdown approaches have also contributed significantly to our knowledge of calpain biology, particularly with respect to the specific functions of different calpain isoforms. The mechanisms by which calpain-mediated proteolysis of individual substrates contributes to cell motility have begun to be addressed, and these efforts have revealed roles for proteolysis of specific substrates in integrin activation, adhesion complex turnover and membrane protrusion dynamics. Understanding these mechanisms should provide avenues for novel therapeutic strategies to treat pathological processes such as tumor metastasis and chronic inflammatory disease.
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Cited by
PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration
Chaitanya, G. V., Alexander, J. S., & Babu, P. P. (2010) · Cell Communication and Signaling · doi:10.1186/1478-811x-8-31 · Cited by 926
Actin and Actin-Binding Proteins
Pollard, T. D. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018226 · Cited by 912
Maness, P. F., & Schachner, M. (2007) · Nature Neuroscience · doi:10.1038/nn1827 · Cited by 847
FAK signaling in human cancer as a target for therapeutics
Lee, B. Y., Timpson, P., Horvath, L. G., & Daly, R. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.10.001 · Cited by 425
Role of Ion Channels and Transporters in Cell Migration
Schwab, A., Fabian, A., Hanley, P. J., & Stock, C. (2012) · Physiological Reviews · doi:10.1152/physrev.00018.2011 · Cited by 420
Metadata
- Authors
- Franco, S. J., & Huttenlocher, A.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2005-09-01
- Volume
- 118
- Issue
- 17
- Pages
- 3829-3838
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2051238023
- Cited by
- 493
- References
- 104
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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