The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif
Abstract
Primary cilia play a key role in the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD). The affected proteins, polycystin-1 (PC1) and polycystin-2 (PC2), interact with each other and are expressed in cilia. We found that COOH-terminal truncated PC2 (PC2-L703X), lacking the PC1 interaction region, still traffics to cilia. We examined PC2 expression in several tissues and cells lacking PC1 and found that PC2 is expressed in cilia independently of PC1. We used N-terminal deletion constructs to narrow the domain necessary for cilia trafficking to the first 15 amino acids of PC2 and identified a conserved motif, R6VxP, that is required for cilial localization. The N-terminal 15 amino acids are also sufficient to localize heterologous proteins in cilia. PC2 has endogenous cilia trafficking information and is present in cilia of cells lining cysts that result from mutations in PKD1.
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Cites
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057
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A motility in the eukaryotic flagellum unrelated to flagellar beating.
Kozminski, K. G., Johnson, K. A., Forscher, P., & Rosenbaum, J. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5519 · Cited by 1,007
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Mutations in PRKCSH cause isolated autosomal dominant polycystic liver disease
Li, A., Davila, S., Furu, L., Qian, Q., Tian, X., Kamath, P. S., King, B. F., Torres, V. E., & Somlo, S. (2003) · The American Journal of Human Genetics · doi:10.1086/368295 · Cited by 193
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Cited by
Venkatachalam, K., & Montell, C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142819 · Cited by 1,909
Autosomal dominant polycystic kidney disease
Torres, V. E., Harris, P. C., & Pirson, Y. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60601-1 · Cited by 1,550
Overview of Structure and Function of Mammalian Cilia
Satir, P., & Christensen, S. T. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.040705.141236 · Cited by 1,142
Ciliogenesis: building the cell's antenna
Ishikawa, H., & Marshall, W. F. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3085 · Cited by 961
Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2
Yoshiba, S., Shiratori, H., Kuo, I. Y., Kawasumi, A., Shinohara, K., Nonaka, S., Asai, Y., Sasaki, G., Belo, J. A., Sasaki, H., et al. (2012) · Science · doi:10.1126/science.1222538 · Cited by 306
Metadata
- Authors
- Geng, L., Okuhara, D., Yu, Z., Tian, X., Cai, Y., Shibazaki, S., & Somlo, S.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2006-04-01
- Volume
- 119
- Issue
- 7
- Pages
- 1383-1395
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W1959400241
- Cited by
- 282
- References
- 5
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Geng, L., Okuhara, D., Yu, Z., Tian, X., Cai, Y., Shibazaki, S., & Somlo, S. (2006). Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif. Journal of Cell Science. https://doi.org/10.1242/jcs.02818
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
