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Microtubule nucleation: γ-tubulin and beyond
Abstract
Centrosomes and their fungal equivalents, spindle pole bodies (SPBs), are the main microtubule (MT)-organizing centers in eukaryotic cells. Several proteins have been implicated in microtubule formation by centrosomes and SPBs, including microtubule-minus-end-binding proteins and proteins that bind along the length or stabilize the plus ends of microtubules. Recent work has improved our understanding of the molecular mechanisms of MT formation. In particular, it has shown that γ-tubulin and its associated proteins play key roles in microtubule nucleation and spindle assembly in evolutionarily distant species ranging from fungi to mammals. Other work indicates that γ-tubulin-mediated microtubule nucleation, although necessary, is not sufficient for mitotic spindle assembly but requires additional proteins that regulate microtubule nucleation independently of centrosomes.
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Cites
Dynamic instability of microtubule growth
Mitchison, T., & Kirschner, M. (1984) · Nature · doi:10.1038/312237a0 · Cited by 3,337
Cited by
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Kollman, J. M., Merdes, A., Mourey, L., & Agard, D. A. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3209 · Cited by 1,583
Branching Microtubule Nucleation in Xenopus Egg Extracts Mediated by Augmin and TPX2
Petry, S., Groen, A. C., Ishihara, K., Mitchison, T. J., & Vale, R. D. (2013) · Cell · doi:10.1016/j.cell.2012.12.044 · Cited by 375
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Kampan, N. C., Madondo, M. T., McNally, O. M., Quinn, M., & Plebanski, M. (2015) · BioMed Research International · doi:10.1155/2015/413076 · Cited by 362
Ori-McKenney, K. M., Jan, L. Y., & Jan, Y.-N. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.008 · Cited by 323
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Metadata
- Authors
- Wiese, C., & Zheng, Y.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2006-10-15
- Volume
- 119
- Issue
- 20
- Pages
- 4143-4153
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2048522844
- Cited by
- 199
- References
- 1
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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