The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Golgi Outposts Shape Dendrite Morphology by Functioning as Sites of Acentrosomal Microtubule Nucleation in Neurons
Open accessAbstract
SUMMARY Microtubule nucleation is essential for proper establishment and maintenance of axons and dendrites. Centrosomes, the primary site of nucleation in most cells, lose their function as microtubule organizing centers during neuronal development. How neurons generate acentrosomal microtubules remains unclear. Drosophila dendritic arborization (da) neurons lack centrosomes and therefore provide a model system to study acentrosomal microtubule nucleation. Here we investigate the origin of microtubules within the elaborate dendritic arbor of class IV da neurons. Using a combination of in vivo and in vitro techniques, we find that Golgi outposts can directly nucleate microtubules throughout the arbor. This acentrosomal nucleation requires gamma-tubulin and CP309, the Drosophila homologue of AKAP450, and contributes to the complex microtubule organization within the arbor, and dendrite branch growth and stability. Together, these results identify the first direct mechanism for acentrosomal microtubule nucleation within neurons, and reveal a previously unknown function for Golgi outposts in this process.
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Cites
Dynamic instability of microtubule growth
Mitchison, T., & Kirschner, M. (1984) · Nature · doi:10.1038/312237a0 · Cited by 3,337
Motor coordination via a tug-of-war mechanism drives bidirectional vesicle transport
Hendricks, A. G., Perlson, E., Ross, J. L., Schroeder, H. W., Tokito, M., & Holzbaur, E. L. F. (2010) · Current Biology · doi:10.1016/j.cub.2010.02.058 · Cited by 423
An Essential Role for Katanin in Severing Microtubules in the Neuron
Ahmad, F. J., Yu, W., McNally, F. J., & Baas, P. W. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.2.305 · Cited by 253
Han, C., Wang, D., Soba, P., Zhu, S., Lin, X., Jan, L. Y., & Jan, Y.-N. (2012) · Neuron · doi:10.1016/j.neuron.2011.10.036 · Cited by 168
Self-citation
Cited by
Mechanisms of microtubule organization in differentiated animal cells
Akhmanova, A., & Kapitein, L. C. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00473-y · Cited by 233
The Role of the Microtubule Cytoskeleton in Neurodevelopmental Disorders
Lasser, M., Tiber, J., & Lowery, L. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00165 · Cited by 201
The cellular basis of dendrite pathology in neurodegenerative diseases
Kweon, J. H., Kim, S., & Lee, S. B. (2017) · BMB Reports · doi:10.5483/bmbrep.2017.50.1.131 · Cited by 73
Architecture and Dynamics of the Neuronal Secretory Network
Kennedy, M. J., & Hanus, C. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100818-125418 · Cited by 63
Ran-dependent TPX2 activation promotes acentrosomal microtubule nucleation in neurons
Chen, W.-S., Chen, Y.-J., Huang, Y.-A., Hsieh, B.-Y., Chiu, H.-C., Kao, P.-Y., Chao, C.-Y., & Hwang, E. (2017) · Scientific Reports · doi:10.1038/srep42297 · Cited by 41
Metadata
- Authors
- Ori-McKenney, K. M., Jan, L. Y., & Jan, Y.-N.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 76
- Issue
- 5
- Pages
- 921-930
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2045419701
- Cited by
- 323
- References
- 4
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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