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Rap1: a key regulator in cell-cell junction formation
Abstract
Rap1 is a Ras-like small GTPase that is activated by many extracellular stimuli and strongly implicated in the control of integrin-mediated cell adhesion. Recent evidence indicates that Rap1 also plays a key role in formation of cadherin-based cell-cell junctions. Indeed, inhibition of Rap1 generates immature adherens junctions, whereas activation of Rap1 tightens cell-cell junctions. Interestingly, Rap1 guanine nucleotide exchange factors, such as C3G and PDZ-GEF, are directly linked to E-cadherin or to other junction proteins. Furthermore, several junction proteins, such as afadin/AF6 and proteins controlling the actin cytoskeleton, function as effectors of Rap1. These findings point to a role of Rap1 in spatial and temporal control of cell-cell junction formation.
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Cites
The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity.
Schwamborn, J. C., & Püschel, A. W. (2004) · Nature Neuroscience · doi:10.1038/nn1295 · Cited by 385
Emerging roles for p120-catenin in cell adhesion and cancer
Reynolds, A. B., & Roczniak-Ferguson, A. (2004) · Oncogene · doi:10.1038/sj.onc.1208161 · Cited by 287
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Dejana, E., Tournier-Lasserve, E., & Weinstein, B. M. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.004 · Cited by 788
Tight junctions/adherens junctions: basic structure and function
Niessen, C. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700865 · Cited by 756
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP
Shibasaki, T., Takahashi, H., Miki, T., Sunaga, Y., Matsumura, K., Yamanaka, M., Zhang, C., Tamamoto, A., Satoh, T., Miyazaki, J.-I., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707054104 · Cited by 425
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival
Drosten, M., Dhawahir, A., Sum, E. Y. M., Urosevic, J., Lechuga, C. G., Esteban, L. M., Castellano, E., Guerra, C., Santos, E., & Barbacid, M. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.7 · Cited by 347
Metadata
- Authors
- Kooistra, M. R. H., Dubé, N., & Bos, J. L.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2007-01-01
- Volume
- 120
- Issue
- 1
- Pages
- 17-22
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W1983790767
- Cited by
- 321
- References
- 2
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kooistra, M. R. H., Dubé, N., & Bos, J. L. (2007). Rap1: a key regulator in cell-cell junction formation. Journal of Cell Science. https://doi.org/10.1242/jcs.03306
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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