Tight junctions/adherens junctions: basic structure and function
Open accessAbstract
Adherens and tight junctions are intercellular junctions crucial for epithelial adhesion and barrier function in a wide variety of tissues and organisms. In stratifying epithelia, such as the epidermis, the role of adherens and tight junctions was considered less important owing to the abundance of desmosomes, mediating firm mechanical stability between the cells, and to the barrier function of the stratum corneum, respectively. This view has changed in recent years because of different studies that showed the importance of these structures for proper skin physiology and barrier function. The current review provides an overview of the crucial molecular constituents of these structures and highlights some recent results on their regulation. In particular, I will discuss their importance in skin biology.
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Enterocytes connect with each other in a continuous epithelial cell layer via adhesive junctional proteins that make up tight junction proteins, adherens junction proteins, gap junction proteins, and desmosomes.
“Enterocytes connect with each other in a continuous epithelial cell layer via adhesive junctional proteins that make up tight junction (TJ) proteins, adherens junction (AJ) proteins, gap junction proteins, and desmosomes (Table 2).31,32”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [31]
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- Authors
- Niessen, C. M.
- Affiliations
- University of Cologne (DE)
- Corresponding author
- Niessen, Carien M.
- ORCID
- Niessen, Carien M.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 127
- Issue
- 11
- Pages
- 2525-2532
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W1980059877
- Cited by
- 756
- References
- 73
- Citations by year
- 2026: 21 · 2025: 44 · 2024: 58 · 2023: 36 · 2022: 48 · 2021: 54 · 2020: 40 · 2019: 34 · 2018: 42 · 2017: 46 · 2016: 37 · 2015: 47 · 2014: 48 · 2013: 42 · 2012: 45
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- tight junctions, adherens junctions, intercellular junctions, epithelial cell adhesion, epithelial barrier function, desmosomes, epidermis, skin physiology, junctional proteins
- MeSH terms
- Nectins, Animals, Epidermis, Humans, Skin Physiological Phenomena, Cell Adhesion Molecules, Cadherins, Tight Junctions, Adherens Junctions
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