The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia
Abstract
When migrating away from a primary tumour, cancer cells interact with and remodel the extracellular matrix (ECM). Matrix metalloproteinases (MMPs), and in particular the transmembrane MT1-MMP (also known as MMP-14), are key enzymes in tumour-cell invasion. Results from recent in vitro studies highlight that MT1-MMP is implicated both in the breaching of basement membranes by tumour cells and in cell invasion through interstitial type-I collagen tissues. Remarkably, MT1-MMP accumulates at invadopodia, which are specialized ECM-degrading membrane protrusions of invasive cells. Here we review current knowledge about MT1-MMP trafficking and its importance for the regulation of protease activity at invadopodia. In invasive cells, endocytosis of MT1-MMP by clathrin- and caveolae-dependent pathways can be counteracted by several mechanisms, which leads to protease stabilization at the cell surface and increased pericellular degradation of the matrix. Furthermore, the recent identification of cellular components that control delivery of MT1-MMP to invadopodia brings new insight into mechanisms of cancer-cell invasion and reveals potential pharmacological targets.
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Citations
Cites
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108
Gaggioli, C., Hooper, S., Hidalgo-Carcedo, C., Grosse, R., Marshall, J. F., Harrington, K., & Sahai, E. (2007) · Nature Cell Biology · doi:10.1038/ncb1658 · Cited by 1,589 · cited 1×
“Interestingly, fibroblasts can support collective invasion by squamous cell carcinoma cells that are otherwise unable to invade (Gaggioli et al., 2007; Zhang et al., 2006).”
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Cited by
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
Nishita, M., Park, S.-Y., Nishio, T., Kamizaki, K., Wang, Z., Tamada, K., Takumi, T., Hashimoto, R., Otani, H., Pazour, G. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-016-0028-x · Cited by 15,947
Ridley, A. J. (2011) · Cell · doi:10.1016/j.cell.2011.06.010 · Cited by 956
The extracellular matrix in tumor progression and metastasis
Eble, J. A., & Niland, S. (2019) · Clinical & Experimental Metastasis · doi:10.1007/s10585-019-09966-1 · Cited by 613
Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia
Schoumacher, M., Goldman, R. D., Louvard, D., & Vignjevic, D. M. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200909113 · Cited by 507
Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression
Niland, S., Riscanevo, A. X., & Eble, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010146 · Cited by 503
Metadata
- Authors
- Poincloux, R., Lizárraga, F., & Chavrier, P.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2009-09-01
- Volume
- 122
- Issue
- 17
- Pages
- 3015-3024
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2166791066
- Cited by
- 504
- References
- 2
- FWCI
- 11.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Poincloux, R., Lizárraga, F., & Chavrier, P. (2009). Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia. Journal of Cell Science. https://doi.org/10.1242/jcs.034561
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