The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia
Open accessAbstract
Invasive cancer cells are believed to breach the basement membrane (BM) using specialized protrusions called invadopodia. We found that the crossing of a native BM is a three-stage process: invadopodia indeed form and perforate the BM, elongate into mature invadopodia, and then guide the cell toward the stromal compartment. We studied the remodeling of cytoskeleton networks during invadopodia formation and elongation using ultrastructural analysis, spatial distribution of molecular markers, and RNA interference silencing of protein expression. We show that formation of invadopodia requires only the actin cytoskeleton and filopodia- and lamellipodia-associated proteins. In contrast, elongation of invadopodia is mostly dependent on filopodial actin machinery. Moreover, intact microtubules and vimentin intermediate filament networks are required for further growth. We propose that invadopodia form by assembly of dendritic/diagonal and bundled actin networks and then mature by elongation of actin bundles, followed by the entry of microtubules and vimentin filaments. These findings provide a link between the epithelial to mesenchymal transition and BM transmigration.
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Cites
Epithelial–mesenchymal transitions in tumour progression
Thiery, J. P. (2002) · Nature Reviews Cancer · doi:10.1038/nrc822 · Cited by 6,628
EMT, the cytoskeleton, and cancer cell invasion
Yilmaz, M., & Christofori, G. (2009) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9169-0 · Cited by 1,788
Filopodia: molecular architecture and cellular functions
Mattila, P. K., & Lappalainen, P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2406 · Cited by 1,719
Svitkina, T. M., & Borisy, G. G. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.5.1009 · Cited by 1,180
Mendez, M. G., Kojima, S., & Goldman, R. D. (2010) · The FASEB Journal · doi:10.1096/fj.09-151639 · Cited by 939
Self-citationAntagonism between Ena/VASP Proteins and Actin Filament Capping Regulates Fibroblast Motility
Bear, J. E., Svitkina, T. M., Krause, M., Schafer, D. A., Loureiro, J. J., Strasser, G. A., Maly, I. V., Chaga, O. Y., Cooper, J. A., Borisy, G. G., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00731-6 · Cited by 847
Mechanism of filopodia initiation by reorganization of a dendritic network
Svitkina, T. M., Bulanova, E. A., Chaga, O. Y., Vignjevic, D. M., Kojima, S.-I., Vasiliev, J. M., & Borisy, G. G. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200210174 · Cited by 770
Self-citationHiggs, H. N., & Pollard, T. D. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.649 · Cited by 673
Molecular mechanisms of invadopodium formation
Yamaguchi, H., Lorenz, M., Kempiak, S., Sarmiento, C., Coniglio, S., Symons, M., Segall, J., Eddy, R., Miki, H., Takenawa, T., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200407076 · Cited by 669
The matrix corroded: podosomes and invadopodia in extracellular matrix degradation
Linder, S. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.01.002 · Cited by 640
Cited by
Actin Dynamics, Architecture, and Mechanics in Cell Motility
Blanchoin, L., Boujemaa-Paterski, R., Sykes, C., & Plastino, J. (2014) · Physiological Reviews · doi:10.1152/physrev.00018.2013 · Cited by 1,457
Wolf, K., te Lindert, M., Krause, M., Alexander, S., te Riet, J., Willis, A. L., Hoffman, R. M., Figdor, C. G., Weiss, S. J., & Friedl, P. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201210152 · Cited by 1,375
Role of Extracellular Matrix in Development and Cancer Progression
Walker, C., Mojares, E., & Del Río Hernández, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103028 · Cited by 1,084
Buratta, S., Tancini, B., Sagini, K., Delo, F., Chiaradia, E., Urbanelli, L., & Emiliani, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072576 · Cited by 446
Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments
Wisdom, K. M., Adebowale, K., Chang, J., Lee, J. Y., Nam, S., Desai, R., Rossen, N. S., Rafat, M., West, R. B., Hodgson, L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06641-z · Cited by 426
Metadata
- Authors
- Schoumacher, M., Goldman, R. D., Louvard, D., & Vignjevic, D. M.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2010-04-26
- Volume
- 189
- Issue
- 3
- Pages
- 541-556
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2018702739
- Cited by
- 507
- References
- 53
- FWCI
- 12.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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