Transcriptional regulation of the cyclin D1 gene at a glance
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Regulated progression through the cell cycle requires sequential expression of a family of proteins called cyclins. Upon their induction, cyclins form complexes with specific cyclin-dependent kinases (CDKs), creating active holoenzymes that phosphorylate target proteins that are required for cell-
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“Importantly, the RAS/ERK pathway is known to converge on several of these same targets and can also control their expression by affecting transcription (e.g., cyclin D1) or protein stability (e.g., MCL1) (26, 27).”
- Authors
- Klein, E. A., & Assoian, R. K.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Assoian, Richard K.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2008-12-01
- Volume
- 121
- Issue
- 23
- Pages
- 3853-3857
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- PMC
- PMC4545630
- OpenAlex
- W2134977493
- Cited by
- 341
- References
- 80
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 11 · 2023: 17 · 2022: 13 · 2021: 19 · 2020: 32 · 2019: 20 · 2018: 28 · 2017: 23 · 2016: 21 · 2015: 28 · 2014: 28 · 2013: 30 · 2012: 27
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA072639)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- cyclin D1, transcriptional regulation, cyclins, cyclin-dependent kinases, cell cycle progression, gene expression regulation
- MeSH terms
- Animals, Binding Sites, Gene Expression Regulation, Humans, Promoter Regions, Genetic, Transcription, Genetic, Cyclin D1
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