Diverse functions within the IAP family
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Inhibitors of apoptosis (IAPs) are a diverse group of signaling molecules that function in a wide range of cellular roles, from the inhibition of caspases to the promotion of cell-cycle progression. These diverse functions may well be linked to the many different domains that are contained within
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IAPs bind to caspase or other pro-apoptotic proteins, hinder their functions, promote their degradation, and thus regulate apoptosis.
“IAPs bind to caspase or other pro-apoptotic proteins, hinder their functions, promote their degradation, and thus regulate apoptosis.455,456”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [455]
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Lu, H., Zhou, Q., He, J., Jiang, Z., Peng, C., Tong, R., & Shi, J. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00315-3 · Cited by 891 · see citing works
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- Authors
- Rumble, J. M., & Duckett, C. S.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Duckett, Colin S.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2008-11-01
- Volume
- 121
- Issue
- 21
- Pages
- 3505-3507
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- PMC
- PMC2754871
- OpenAlex
- W2119505616
- Cited by
- 40
- References
- 27
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 5 · 2022: 1 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 2 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM067827)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- inhibitor of apoptosis proteins, IAP family, caspase inhibition, cell cycle progression
- MeSH terms
- Survivin, Animals, Cell Cycle, Multigene Family, Humans, Microtubule-Associated Proteins, Mitochondria, Models, Biological, Transcription, Genetic, Signal Transduction, NF-kappa B, Caspases, Cell Line, Tumor, Inhibitor of Apoptosis Proteins
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