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Mechanism underlying activity-dependent insertion of TrkB into the neuronal surface

Zhao, Ling, Sheng, Ai-Li, Huang, Shu-Hong, Yin, Yu-Xia, Chen, Bing, Li, Xue-Zhi, Zhang, Yun, Chen, Zhe-Yu·2009·Journal of Cell Science
DOI 10.1242/jcs.047712
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Abstract

Activity-dependent insertion of tyrosine kinase receptor type 2 (TrkB receptor) into the plasma membrane can explain, in part, the preferential effect of brain-derived neurotrophic factor (BDNF) on active neurons; however, the detailed cellular and molecular mechanisms underlying this process are still unclear. In our study, we developed a fluorescence ratiometric assay for surface TrkB receptors to investigate the mechanisms of recruitment of TrkB to the plasma membrane following chemical long-term potentiation (cLTP) induction. We found that, in hippocampal neurons, the effect of cLTP-induced TrkB surface-recruitment occurred predominantly on neurites with rapid kinetics (t1/2 of ∼2.3 minutes) and was dependent on an intact cytoskeleton structure. Mutagenesis studies revealed that the juxtamembrane domain of TrkB is necessary and sufficient for its activity-dependent insertion into the plasma membrane. Moreover, we found that the phosphorylation of TrkB receptor at the Ser478 site by cyclin-dependent kinase 5 (Cdk5) is essential for cLTP-induced TrkB insertion into the neuronal surface. Finally, the degree of cLTP-induced TrkB surface-recruitment is higher in postsynaptic regions, which provides a potential mechanism for rapid enhancement of postsynaptic sensitivity to incoming BDNF signaling. Our studies provide new insights regarding neuronal activity-dependent surface delivery of TrkB receptor, which will advance our understanding of the modulatory role of TrkB in synaptic plasticity.

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  1. Angelo, M., Plattner, F. and Giese, K. P. (2006). Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory. J. Neurochem.99, 353-370. · DOI
  2. Arancio, O. and Chao, M. V. (2007). Neurotrophins, synaptic plasticity and dementia. Curr. Opin. Neurobiol.17, 325-330. · DOI · Paper page
  3. Arevalo, J. C., Waite, J., Rajagopal, R., Beyna, M., Chen, Z. Y., Lee, F. S. and Chao, M. V. (2006). Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination. Neuron50, 549-559. · DOI
  4. Bonhoeffer, T. (1996). Neurotrophins and activity-dependent development of the neocortex. Curr. Opin. Neurobiol.6, 119-126. · DOI
  5. Bramham, C. R. and Messaoudi, E. (2005). BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog. Neurobiol.76, 99-125. · DOI · Paper page
  6. Chen, Z. Y., Patel, P. D., Sant, G., Meng, C. X., Teng, K. K., Hempstead, B. L. and Lee, F. S. (2004). Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J. Neurosci.24, 4401-4411. · DOI · Paper page
  7. Cheung, Z. H., Fu, A. K. and Ip, N. Y. (2006). Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases. Neuron50, 13-18. · DOI
  8. Cheung, Z. H., Chin, W. H., Chen, Y., Ng, Y. P. and Ip, N. Y. (2007). Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. PLoS Biol.5, e63. · DOI
  9. Cohen, S. and Greenberg, M. E. (2008). Communication between the synapse and the nucleus in neuronal development, plasticity, and disease. Annu. Rev. Cell Dev. Biol.24, 183-209. · DOI · Paper page
  10. Cooper, J. A., Bryan, J., Schwab, B., 3rd, Frieden, C., Loftus, D. J. and Elson, E. L. (1987). Microinjection of gelsolin into living cells. J. Cell Biol.104, 491-501. · DOI
  11. Crozier, R. A., Bi, C., Han, Y. R. and Plummer, M. R. (2008). BDNF modulation of NMDA receptors is activity dependent. J. Neurophysiol.100, 3264-3274. · DOI
  12. Delcroix, J. D., Valletta, J. S., Wu, C., Hunt, S. J., Kowal, A. S. and Mobley, W. C. (2003). NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron39, 69-84. · DOI
  13. Drake, C. T., Milner, T. A. and Patterson, S. L. (1999). Ultrastructural localization of full-length trkB immunoreactivity in rat hippocampus suggests multiple roles in modulating activity-dependent synaptic plasticity. J. Neurosci.19, 8009-8026. · DOI
  14. Du, J., Feng, L., Yang, F. and Lu, B. (2000). Activity- and Ca(2+)-dependent modulation of surface expression of brain-derived neurotrophic factor receptors in hippocampal neurons. J. Cell Biol.150, 1423-1434. · DOI · Paper page
  15. Du, J., Feng, L., Zaitsev, E., Je, H. S., Liu, X. W. and Lu, B. (2003). Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx. J. Cell Biol.163, 385-395. · DOI
  16. Haapasalo, A., Sipola, I., Larsson, K., Akerman, K. E., Stoilov, P., Stamm, S., Wong, G. and Castren, E. (2002). Regulation of TRKB surface expression by brain-derived neurotrophic factor and truncated TRKB isoforms. J. Biol. Chem.277, 43160-43167. · DOI
  17. Hawasli, A. H. and Bibb, J. A. (2007). Alternative roles for Cdk5 in learning and synaptic plasticity. Biotechnol. J.2, 941-948. · DOI
  18. Heerssen, H. M., Pazyra, M. F. and Segal, R. A. (2004). Dynein motors transport activated Trks to promote survival of target-dependent neurons. Nat. Neurosci.7, 596-604. · DOI
  19. Huang, E. J. and Reichardt, L. F. (2001). Neurotrophins: roles in neuronal development and function. Annu. Rev. Neurosci.24, 677-736. · DOI · Paper page
  20. Ji, Y., Pang, P. T., Feng, L. and Lu, B. (2005). Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons. Nat. Neurosci.8, 164-172. · DOI
  21. Jullien, J., Guili, V., Derrington, E. A., Darlix, J. L., Reichardt, L. F. and Rudkin, B. B. (2003). Trafficking of TrkA-green fluorescent protein chimerae during nerve growth factor-induced differentiation. J. Biol. Chem.278, 8706-8716. · DOI
  22. Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H. and Bonhoeffer, T. (1995). Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc. Natl. Acad. Sci. USA92, 8856-8860. · DOI · Paper page
  23. Kryl, D., Yacoubian, T., Haapasalo, A., Castren, E., Lo, D. and Barker, P. A. (1999). Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells. J. Neurosci.19, 5823-5833. · DOI · Paper page
  24. Lessmann, V., Gottmann, K. and Malcangio, M. (2003). Neurotrophin secretion: current facts and future prospects. Prog. Neurobiol.69, 341-374. · DOI
  25. Lu, B. (2003). BDNF and activity-dependent synaptic modulation. Learn. Mem.10, 86-98. · DOI · Paper page
  26. Lu, W., Man, H., Ju, W., Trimble, W. S., MacDonald, J. F. and Wang, Y. T. (2001). Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons. Neuron29, 243-254. · DOI
  27. Lu, Y., Christian, K. and Lu, B. (2008). BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiol. Learn. Mem.89, 312-323. · DOI
  28. Martinowich, K., Manji, H. and Lu, B. (2007). New insights into BDNF function in depression and anxiety. Nat. Neurosci.10, 1089-1093. · DOI · Paper page
  29. McAllister, A. K., Katz, L. C. and Lo, D. C. (1996). Neurotrophin regulation of cortical dendritic growth requires activity. Neuron17, 1057-1064. · DOI · Paper page
  30. Middlemas, D. S., Lindberg, R. A. and Hunter, T. (1991). trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. Mol. Cell. Biol.11, 143-153. · DOI
  31. Musleh, W., Bi, X., Tocco, G., Yaghoubi, S. and Baudry, M. (1997). Glycine-induced long-term potentiation is associated with structural and functional modifications of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid receptors. Proc. Natl. Acad. Sci. USA94, 9451-9456. · DOI · Paper page
  32. Nagappan, G. and Lu, B. (2005). Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications. Trends Neurosci.28, 464-471. · DOI
  33. Park, M., Salgado, J. M., Ostroff, L., Helton, T. D., Robinson, C. G., Harris, K. M. and Ehlers, M. D. (2006). Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes. Neuron52, 817-830. · DOI · Paper page
  34. Patterson, S. L., Abel, T., Deuel, T. A., Martin, K. C., Rose, J. C. and Kandel, E. R. (1996). Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron16, 1137-1145. · DOI · Paper page
  35. Yang, H. W., Hu, X. D., Zhang, H. M., Xin, W. J., Li, M. T., Zhang, T., Zhou, L. J. and Liu, X. G. (2004). Roles of CaMKII, PKA, and PKC in the induction and maintenance of LTP of C-fiber-evoked field potentials in rat spinal dorsal horn. J. Neurophysiol.91, 1122-1133. · DOI
  36. Yudowski, G. A., Puthenveedu, M. A., Leonoudakis, D., Panicker, S., Thorn, K. S., Beattie, E. C. and von Zastrow, M. (2007). Real-time imaging of discrete exocytic events mediating surface delivery of AMPA receptors. J. Neurosci.27, 11112-11121. · DOI · Paper page

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Metadata

Authors
Zhao, L., Sheng, A.-L., Huang, S.-H., Yin, Y.-X., Chen, B., Li, X.-Z., Zhang, Y., & Chen, Z.-Y.
Affiliations
  • Department of Neurobiology, Key Laboratory of Medical Neurobiology, School of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China
  • Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China
Venue
Journal of Cell Science
Publisher
The Company of Biologists
Published
2009-09-01
Volume
122
Issue
17
Pages
3123-3136
ISSN
  • 1477-9137
  • 0021-9533
DOI
10.1242/jcs.047712
Cited by
35
References
8
Language
en

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