The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The regulation of autophagy – unanswered questions
Open accessAbstract
Autophagy is an intracellular lysosomal (vacuolar) degradation process that is characterized by the formation of double-membrane vesicles, known as autophagosomes, which sequester cytoplasm. As autophagy is involved in cell growth, survival, development and death, the levels of autophagy must be properly regulated, as indicated by the fact that dysregulated autophagy has been linked to many human pathophysiologies, such as cancer, myopathies, neurodegeneration, heart and liver diseases, and gastrointestinal disorders. Substantial progress has recently been made in understanding the molecular mechanisms of the autophagy machinery, and in the regulation of autophagy. However, many unanswered questions remain, such as how the Atg1 complex is activated and the function of PtdIns3K is regulated, how the ubiquitin-like conjugation systems participate in autophagy and the mechanisms of phagophore expansion and autophagosome formation, how the network of TOR signaling pathways regulating autophagy are controlled, and what the underlying mechanisms are for the pro-cell survival and the pro-cell death effects of autophagy. As several recent reviews have comprehensively summarized the recent progress in the regulation of autophagy, we focus in this Commentary on the main unresolved questions in this field.
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Cites
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
Self-citationAMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
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Self-citationReactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
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BackgroundNetwork organization of the human autophagy system
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Cited by
An Overview of Autophagy: Morphology, Mechanism, and Regulation
Parzych, K. R., & Klionsky, D. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5371 · Cited by 2,521
Self-citationAutophagy, mitochondria and oxidative stress: cross-talk and redox signalling.
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Mitochondria and cell signalling
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Cell death by autophagy: facts and apparent artefacts
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Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates
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Metadata
- Authors
- Chen, Y., & Klionsky, D. J.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2011-01-15
- Volume
- 124
- Issue
- 2
- Pages
- 161-170
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2031169909
- Cited by
- 591
- References
- 20
- FWCI
- 35.43
- Type
- journal article
- Language
- en
- Open access
- green
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