The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
United we stand – integrating the actin cytoskeleton and cell–matrix adhesions in cellular mechanotransduction
Open accessAbstract
Many essential cellular functions in health and disease are closely linked to the ability of cells to respond to mechanical forces. In the context of cell adhesion to the extracellular matrix, the forces that are generated within the actin cytoskeleton and transmitted through integrin-based focal adhesions are essential for the cellular response to environmental clues, such as the spatial distribution of adhesive ligands or matrix stiffness. Whereas substantial progress has been made in identifying mechanosensitive molecules that can transduce mechanical force into biochemical signals, much less is known about the nature of cytoskeletal force generation and transmission that regulates the magnitude, duration and spatial distribution of forces imposed on these mechanosensitive complexes. By focusing on cell-matrix adhesion to flat elastic substrates, on which traction forces can be measured with high temporal and spatial resolution, we discuss our current understanding of the physical mechanisms that integrate a large range of molecular mechanotransduction events on cellular scales. Physical limits of stability emerge as one important element of the cellular response that complements the structural changes affected by regulatory systems in response to mechanical processes.
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Citations
Cites
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
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Cited by
Actin Dynamics, Architecture, and Mechanics in Cell Motility
Blanchoin, L., Boujemaa-Paterski, R., Sykes, C., & Plastino, J. (2014) · Physiological Reviews · doi:10.1152/physrev.00018.2013 · Cited by 1,457
Advancing biomaterials of human origin for tissue engineering
Chen, F.-M., & Liu, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2015.02.004 · Cited by 1,158
Traction force microscopy in physics and biology
Style, R. W., Boltyanskiy, R., German, G. K., Hyland, C., MacMinn, C. W., Mertz, A. F., Wilen, L. A., Xu, Y., & Dufresne, E. R. (2014) · Soft Matter · doi:10.1039/c4sm00264d · Cited by 349
At the leading edge of three-dimensional cell migration
Petrie, R. J., & Yamada, K. M. (2012) · Journal of Cell Science · doi:10.1242/jcs.093732 · Cited by 317
Ray, A., Lee, O., Win, Z., Edwards, R. M., Alford, P. W., Kim, D.-H., & Provenzano, P. P. (2017) · Nature Communications · doi:10.1038/ncomms14923 · Cited by 293
Metadata
- Authors
- Schwarz, U. S., & Gardel, M. L.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2012-01-01
- Volume
- 125
- Issue
- Pt 13
- Pages
- 3051-60
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2150338395
- Cited by
- 339
- References
- 118
- FWCI
- 17.06
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
