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Lamin proteins form an internal nucleoskeleton as well as a peripheral lamina in human cells
Abstract
The nuclear lamina forms a protein mesh that underlies the nuclear membrane. In most mammalian cells it contains the intermediate filament proteins, lamins A, B and C. As their name indicates, lamins are generally thought to be confined to the nuclear periphery. We now show that they also form part of a diffuse skeleton that ramifies throughout the interior of the nucleus. Unlike their peripheral counterparts, these internal lamins are buried in dense chromatin and so are inaccessible to antibodies, but accessibility can be increased by removing chromatin. Knobs and nodes on an internal skeleton can then be immunola-belled using fluorescein- or gold-conjugated anti-lamin A antibodies. These results suggest that the lamins are misnamed as they are also found internally.
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Citations
Cited by
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus
Wang, N., Tytell, J. D., & Ingber, D. E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2594 · Cited by 1,762
Dechat, T., Pfleghaar, K., Sengupta, K., Shimi, T., Shumaker, D. K., Solimando, L., & Goldman, R. D. (2008) · Genes & Development · doi:10.1101/gad.1652708 · Cited by 940
Nuclear lamins: building blocks of nuclear architecture
Goldman, R. D., Gruenbaum, Y., Moir, R. D., Shumaker, D. K., & Spann, T. P. (2002) · Genes & Development · doi:10.1101/gad.960502 · Cited by 586
Dittmer, T. A., & Misteli, T. (2011) · Genome Biology · doi:10.1186/gb-2011-12-5-222 · Cited by 481
Moir, R. D., Yoon, M., Khuon, S., & Goldman, R. D. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.6.1155 · Cited by 401
Metadata
- Authors
- Hozák, P., Marie-Josée Sasseville, A., Raymond, Y., & Cook, P. R.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 1995-02-01
- Volume
- 108
- Issue
- 2
- Pages
- 635-644
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2133779787
- Cited by
- 315
- References
- 0
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Lamin proteins form an internal nucleoskeleton as well as a peripheral lamina in human cells. https://app.cochat.ai/papers/10.1242/jcs.108.2.635
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- Hozák, P., Marie-Josée Sasseville, A., Raymond, Y., & Cook, P. R. (1995). Lamin proteins form an internal nucleoskeleton as well as a peripheral lamina in human cells. Journal of Cell Science. https://doi.org/10.1242/jcs.108.2.635
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