The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells
Abstract
Stem cells are vital for the homeostasis of self-renewing tissues such as the hair follicle. Epithelial stem cells have been implicated in tumorigenesis and wound healing, and their manipulation may have wide ranging applications including gene therapy and tissue transplantation. Rodent hair follicle stem cells have been localized to an area of the follicle called the bulge, however, the identification and characterization of human hair follicle stem cells has been hampered by a lack of cellular markers for this area. We have determined that the C8/144B monoclonal antibody, originally generated against a short intracytoplasmic peptide of CD8, preferentially immunostains hair follicle bulge keratinocytes without staining the remaining hair follicle. Using expression cloning, we identified cytokeratin 15 as the keratinocyte protein recognized by the C8/144B monoclonal antibody. By delineating the bulge using this antibody, we demonstrated that bulge cells possess a stem cell phenotype characterized by their slowly-cycling nature, preferential proliferation at the onset of new hair follicle growth, high level of β1 integrin expression, and expression of cytokeratin 19.
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Cotsarelis, G., Sun, T.-T., & Lavker, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90696-c · Cited by 2,276
Self-citation
Cited by
The human keratins: biology and pathology
Moll, R., Divo, M., & Langbein, L. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0435-6 · Cited by 1,465
Ito, M., Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R. J., & Cotsarelis, G. (2005) · Nature Medicine · doi:10.1038/nm1328 · Cited by 1,314
Self-citationCapturing and profiling adult hair follicle stem cells
Morris, R. J., Liu, Y., Marles, L., Yang, Z., Trempus, C., Li, S., Lin, J. S., Sawicki, J. A., & Cotsarelis, G. (2004) · Nature Biotechnology · doi:10.1038/nbt950 · Cited by 1,283
Self-citationInvolvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis
Taylor, G., Lehrer, M. S., Jensen, P. J., Sun, T.-T., & Lavker, R. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00050-7 · Cited by 1,070
Molecular Mechanisms Regulating Hair Follicle Development
Millar, S. E. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01670.x · Cited by 967
Metadata
- Authors
- Lyle, S., Christofidou-Solomidou, M., Liu, Y., Elder, D. E., Albelda, S., & Cotsarelis, G.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 1998-11-01
- Volume
- 111
- Issue
- 21
- Pages
- 3179-3188
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2156891963
- Cited by
- 539
- References
- 1
- FWCI
- 16.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. https://app.cochat.ai/papers/10.1242/jcs.111.21.3179
- The paper
- Lyle, S., Christofidou-Solomidou, M., Liu, Y., Elder, D. E., Albelda, S., & Cotsarelis, G. (1998). The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. Journal of Cell Science. https://doi.org/10.1242/jcs.111.21.3179
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
